Results 221 to 230 of about 648,804 (352)

Discovery of a Potent and Selective TEAD Degrader with Durable Degradation Activity

Advanced Science, EarlyView.
KG‐FP‐003, a highly potent TEAD‐YAP PROTAC derived from the patented inhibitor is developed. It selectively degrades endogenous TEAD proteins in HiBiT systems without IMiD‐related off‐target effects. Screening across 867 cancer cell lines revealed broad and superior anti‐tumor activity, highlighting its therapeutic potential through targeted TEAD ...
Linhui Cao, Jing Yang, Yuhang Liu, Xiaotong Chen, Yufang Shi, Yunshuo Zhao, Yong Zhang, Jian Chen, Bowen Li, Wuqiang Wen, Lu Chen, Bo Peng, Lu Huang, Yanli Sun, Lixin Zhou, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Zhixiang Guo, Jing Xing, Guangya Zhu, Yazhou Wang, Baishan Jiang, Jing Lu, Kehao Zhao, Wenchao Lu   +25 more
wiley   +1 more source

Internal translation of truncated protein isoforms throughout the connexin gene family. [PDF]

Genes Dis
Muñoz MJ, Cabrera-Andrade A, Gutierrez-Aguirregabiria A, Gönenc II, Ramón Y Cajal S, Aasen T.   +5 more
europepmc   +1 more source

Multimodal detection of protein isoforms and nucleic acids from low starting cell numbers. [PDF]

Lab Chip, 2021
Rosàs-Canyelles E, Modzelewski AJ, Gomez Martinez AE, Geldert A, Gopal A, He L, Herr AE.   +6 more
europepmc   +1 more source

Selective Interactions of Krüppel-like Factor 9/Basic Transcription Element-binding Protein with Progesterone Receptor Isoforms A and B Determine Transcriptional Activity of Progesterone-responsive Genes in Endometrial Epithelial Cells [PDF]

, 2003
Xuelian Zhang, Daying Zhang, Frank Michel, Jason L. Blum, Frank A. Simmen, Rosalia C.M. Simmen   +5 more
openalex   +1 more source

CRISPRa Lipid Nanocomplex‐Mediated Mt3 Targeting Enhances Astrocytic Endocytosis of Amyloid‐β in an Alzheimer's Disease Mouse Model

Advanced Science, EarlyView.
GeTe exhibits intrinsically high carrier concentrations that limit its thermoelectric performance. Herein, CuAgSe alloying synergistically tunes the band structure, induces band flattening and valence‐band convergence, promotes Cu‐ion delocalization, and generates multiscale hierarchical structures to suppress phonon transport.
Junhang Park, Boyoung Kim, Minki Ha, Moonsu Park, Hongji Ryu, Hyerin Yu, Sungsoo Park, Yoon‐Seok Roh, Key‐Hwan Lim, Jin Tae Hong, Sang‐Bae Han, Chun‐Woong Park, Seok‐Beom Yong, Hanseul Park   +13 more
wiley   +1 more source

Protein kinase C isoform expression as a predictor of disease outcome on endocrine therapy in breast cancer [PDF]

, 2007
Jean W. Assender, Julia M.W. Gee, Ian Lewis, Ian O. Ellis, J.F.R. Robertson, Robert I. Nicholson   +5 more
openalex   +1 more source

Alternative Splicing and Polyadenylation Contribute to the Generation of hERG1 C-terminal Isoforms

, 2010
The human ether-a-go-go-related gene 1 (hERG1) encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel. Several hERG1 isoforms with different N- and C-terminal ends have been identified.
Gong, Qiuming, Stump, Matthew R., Dunn, A. Russell, Deng, Vivianne, Zhou, Zhengfeng   +4 more
core  

A Modular and Customizable CRISPR/Cas Toolkit for Epigenome Editing of Cis‐regulatory Modules

Advanced Science, EarlyView.
Epigenome editing surpasses genome editing in gene regulation. Modular epigenome editing frameworks are developed to interrogate cis‐regulome, enabling tunable reprogramming of cis‐elements, uncovering their epigenetic responsiveness and cross‐species portability.
Lingrui Zhang, Jianxin Fu, Tiandan Long, Chao Zhang, Fuhua Fan, Zhaobo Lang, Jian‐Kang Zhu   +6 more
wiley   +1 more source

A-to-I mRNA editing recodes hundreds of genes in dozens of species and produces endogenous protein isoforms in bacteria. [PDF]

Nucleic Acids Res
Elias E, Gifford I, Didi L, Fargeon O, Arad D, Cohen-Pavon R, Sorek G, Levin L, Melamed D, Aspit L, Barrick JE, Bar-Yaacov D.   +11 more
europepmc   +1 more source

Muscle Organoids Reveal Exercise‐Like Contractions Rapidly Promote Muscle Health Via Lamtor1's Signaling to Both AMPK and mTOR

Advanced Science, EarlyView.
This study develops a novel 3D human skeletal muscle organoid platform to study the immediate molecular effects of exercise‐like contractions. The model uncovers rapid proteomic and transcriptomic responses, resolving a fundamental paradox by demonstrating how exercise‐induced Lamtor1 coordinately activates both AMPK and mTORC1. Lamtor1 is a compelling
Ziyue Yao, Zongmin Jiang, Xupeng Liu, Liping Zhang, Siyu Guo, Yu Chen, Lanfang Luo, Shilin Ma, Peng Wang, Ng Shyh‐Chang   +9 more
wiley   +1 more source