Results 231 to 240 of about 648,804 (352)

Identification and characterization of human KALRN mRNA and Kalirin protein isoforms. [PDF]

Cereb Cortex
Mould AW, Wright DJ, Bornemann KD, Hengerer B, Pinnock R, Drydale E, Bancroft J, Hall NAL, von Delft A, Brennan PE, Harrison PJ, Haerty W, Tunbridge EM.   +12 more
europepmc   +1 more source

1P112 Analysis of calmodulin binding to nNOS isoforms using surface plasmon resonance(Heme proteins,The 48th Annual Meeting of the Biophysical Society of Japan)

, 2010
Kaori Azuma, Masayuki Oda, Sumio Ishijima, Ikuko Sagami   +3 more
openalex   +2 more sources

Disease Transmission by Misfolded Prion-Protein Isoforms, Prion-Like Amyloids, Functional Amyloids and the Central Dogma [PDF]

, 2016
Martin L. Daus
openalex   +1 more source

Adenylosuccinate Synthase 1 Deficiency Improves Energy Metabolism by Promoting Adipose Tissue Re‐esterification via Glycerol Kinase Upregulation

Advanced Science, EarlyView.
Working model of Adss1‐mediated regulation of energy metabolism in adipose tissue. In beige adipocytes, Adss1 interacts with HDAC3 in the cytoplasm, and its loss reduces nuclear HDAC3 while increasing cytosolic fractions. This redistribution suppresses HDAC activity and enhances H3K27 acetylation at the Gk promoter, leading to transcriptional ...
Jingjing Sun, Miriayi Alimujiang, Wenfei Li, Shuqin Chen, Yingying Su, Tingting Hu, Xuhong Lu, Yafen Ye, Ningning Bai, Fan Hu, Xiaoya Li, Rongrong Xu, Jun Xu, Jiarui Zhao, Yan Lu, Xiaojing Ma, Ying Yang   +16 more
wiley   +1 more source

ASpdb: an integrative knowledgebase of human protein isoforms from experimental and AI-predicted structures. [PDF]

Nucleic Acids Res
Yang Y, Kumar H, Xie Y, Li Z, Li R, Chen W, Diala CS, Ali MA, Xu Y, Wu A, Hosseini SR, Bi E, Zhao H, Kim P, Zheng WJ.   +14 more
europepmc   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Distinct interactomes of ADAR1 nuclear and cytoplasmic protein isoforms and their responses to interferon induction. [PDF]

Nucleic Acids Res
Vukić D, Cherian A, Keskitalo S, Bong YT, Marônek M, Yadav L, Keegan LP, Varjosalo M, O'Connell MA.   +8 more
europepmc   +1 more source

FMO2 Promotes Angiogenesis via Regulation of N‐Acetylornithine

Advanced Science, EarlyView.
This study identifies flavin‐containing monooxygenase 2 (FMO2) as a novel proangiogenic regulator in endothelial cells. Targeted FMO2 ablation impairs vessel sprouting, whereas its compensation potently enhances angiogenesis. Metabolomics and single‐cell sequencing reveal that FMO2 drives vascular growth via the N‐acetylornithine/ATF3/NOTCH1 axis ...
Jingyi Wang, Yinghui Xu, Xianpeng Wu, Mo Li, Changchen Xiao, Zaiyang Fu, Yongjian Chen, Qingju Li, Yating Ruan, Jing Zhao, Zhiwei Zhong, Jinghai Chen, Wei Zhu, Jinliang Nan, Cheng Ni, Xinyang Hu   +15 more
wiley   +1 more source

Corrigendum: C-reactive protein isoforms as prognostic markers of COVID-19 severity. [PDF]

Front Immunol
Molins B, Figueras-Roca M, Valero O, Llorens V, Romero-Vázquez S, Sibila O, Adan A, Garcia-Vidal C, Soriano A.   +8 more
europepmc   +1 more source

Inhibition of Hypersialylation in Human Intervertebral Disc Degeneration Modulates Inflammation and Metabolism

Advanced Science, EarlyView.
Glycosylation, specifically hypersialylation, is identified as a critical factor in human intervertebral disc (IVD) degeneration—a major cause of low back pain. This study demonstrates that inhibiting sialylation reduces inflammation and oxidative stress in IVD tissues, suggesting new therapeutic possibilities.
Kieran Joyce, Aert F. Scheper, Aung Myat Phyo, Roisin O’ Flaherty, Richard Drake, Aiden Devitt, Martina Marchetti‐Deschmann, Radka Saldova, Abhay Pandit   +8 more
wiley   +1 more source