Results 311 to 320 of about 6,367,317 (393)

M3 Muscarinic Acetylcholine Receptors Regulate Cytoplasmic Myosin by a Process Involving RhoA and Requiring Conventional Protein Kinase C Isoforms

, 1999
Derek Strassheim, Lisa G. May, Kimberly A. Varker, Henry L. Puhl, Scott H. Phelps, Rebecca A. Porter, Robert S. Aronstam, John D. Noti, Carol L. Williams   +8 more
openalex   +1 more source

U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies

Nature Cell Biology, 2019
Molly A Smith, G. Choudhary, A. Pellagatti, Kwangmin Choi, L. Bolanos, T. Bhagat, Shanisha Gordon-Mitchell, Dagny von Ahrens, K. Pradhan, V. Steeples, Sanghyun P. Kim, U. Steidl, M. Walter, I. Fraser, A. Kulkarni, N. Salomonis, K. Komurov, J. Boultwood, A. Verma, D. Starczynowski   +19 more
semanticscholar   +1 more source

Disease-associated genetic variants can cause mutations in tissue-specific protein isoforms

Weykopf G, Badonyi M, Friman ET, Nguyen JMH, Ioannou A, Livesey BJ, Coutts A, Hird EF, Wham M, Stanton CM, Vitart V, Su J, Murphy L, Baillie JK, Gorrell MD, Marsh JA, Bickmore WA, Biddie SC.   +17 more
europepmc   +1 more source

Magnetically‐Induced Suppression of Oxidative Stress Prevents Venous Thrombosis

Advanced Science, EarlyView.
Venous thromboembolism (VTE) remains a leading cause of cardiovascular mortality. This study demonstrates that static magnetic fields (SMF) offer a novel non‐pharmacological intervention against VTE by mitigating endothelial oxidative stress. Mechanistically, SMF elevates intracellular Ca2+, boosts ATP production, and suppresses NOX4‐mediated ROS ...
Nana Zhang, Yirong An, Shiran Tao, Shenao Qu, Minge Wu, Guantong Fang, Ziqing Chen, Weilun Song, Haoze Leng, Rongqian Wu, Yi Lyu, Xiaoli Liu, Dinghui Dong   +12 more
wiley   +1 more source

Investigating protein isoforms via proteomics: A feasibility study

Proteomics, 2010
Paul Blakeley, Jennifer A. Siepen, C. Lawless, S. Hubbard   +3 more
semanticscholar   +1 more source

Syntaxin 3B Mediates Light‐Dependent Interactions with STXBP1 and Arrestin 4: Distinct Roles in Rods and Cones

Advanced Science, EarlyView.
The present study investigates a cone‐specific STX3 knockout model, displaying a complete loss of cone function, a later onset reduction in rod function, and photoreceptor cell death. A cone‐specific depletion of STXBP1 and ARR4 could be observed in this model.
Lars Tebbe, Larissa Ikelle, Mustafa S. Makia, Mashal Kakakhel, Muayyad R. Al‐Ubaidi, Muna I. Naash   +5 more
wiley   +1 more source

Identification and Characterization of Three Epithiospecifier Protein Isoforms in Brassica oleracea. [PDF]

Front Plant Sci, 2019
Witzel K, Abu Risha M, Albers P, Börnke F, Hanschen FS.   +4 more
europepmc   +1 more source

Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

Advanced Science, EarlyView.
Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao, Qian Hao, Yu Gan, Jing Tong, Xiaodan Chen, Shuran Tan, Ruiwen Ruan, Yingdan Huang, Mingming Cao, Jun Deng, Tao Han, Getao Shi, Bo Gao, Yu Zhang, Xiang Zhou   +14 more
wiley   +1 more source

The fatty acid desaturase 3 gene encodes for different FADS3 protein isoforms in mammalian tissues

Journal of Lipid Research, 2010
F. Pédrono, H. Blanchard, M. Kloareg, S. d’Andrea, S. Daval, V. Rioux, P. Legrand   +6 more
semanticscholar   +1 more source