Results 121 to 130 of about 1,326,529 (167)

A new family of protein kinases— The mitochondrial protein kinases

Advances in Enzyme Regulation, 1995
Molecular cloning has provided evidence for a new family of protein kinases in eukaryotic cells. These kinases show no sequence similarity with other eukaryotic protein kinases, but are related by sequence to the histidine protein kinases found in prokaryotes. These protein kinases, responsible for phosphorylation and inactivation of the branched-chain
R A, Harris, K M, Popov, Y, Zhao, N Y, Kedishvili, Y, Shimomura, D W, Crabb   +5 more
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A-kinase anchoring protein targeting of protein kinase A in the heart

Journal of Molecular and Cellular Cardiology, 2004
There is increasing evidence that subcellular targeting of signaling molecules is an important means of regulating the protein kinase A (PKA) pathway. Subcellular organization of the signaling molecules in the PKA pathway insures that a signal initiated at the receptor level is transferred efficiently to a PKA substrate eliciting some cellular response.
Mary L, Ruehr, Mary A, Russell, Meredith, Bond   +2 more
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Method for Simultaneous Detection of Protein Kinase A, Protein Kinase C, Protein Tyrosine Kinase, and Calmodulin-Dependent Protein Kinase Activities

Analytical Biochemistry, 1993
We report a simple method that permits simultaneous detection of multiple protein kinase activities using postnuclear supernatant of v-src transformed NIH3T3 cells. A supernatant is incubated with activators of protein kinases and [gamma-32P]ATP, and the phosphorylated proteins are analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis ...
H, Fukazawa, P M, Li, S, Mizuno, Y, Uehara   +3 more
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Protein Kinase D Is a Downstream Target of Protein Kinase Cθ

Biochemical and Biophysical Research Communications, 2002
Protein kinase D (PKD/PKCmu immunoprecipitated from either COS-7 cells or Jurkat T lymphocytes transiently transfected with a constitutively active mutant of PKCtheta AE (PKCthetaAE) exhibited a marked increase in basal activity. In contrast, coexpression of constitutively active mutant of PKCzeta does not induce PKD activation in both types of cells ...
Jingzhen, Yuan, David, Bae, Doreen, Cantrell, Andre E, Nel, Enrique, Rozengurt   +4 more
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Regulation of a Mitogen-Activated Protein Kinase Kinase Kinase, MLTK by PKN

Journal of Biochemistry, 2003
PKNalpha is a fatty acid- and Rho-activated serine/threonine protein kinase having a catalytic domain homologous to members of the protein kinase C family. Recently it was reported that PKNalpha is involved in the p38 mitogen-activated protein kinase (MAPK) signaling pathway.
Mikiko, Takahashi, Yusuke, Gotoh, Takayuki, Isagawa, Tamako, Nishimura, Emiko, Goyama, Hon-Song, Kim, Hideyuki, Mukai, Yoshitaka, Ono   +7 more
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Protein kinase C — a family affair

Molecular and Cellular Endocrinology, 1989
The structural analysis of protein kinase C has led to the identification of a family of related gene products. This family of kinases consists of six unique genes that give rise to at least seven polypeptides. The high degree of conservation and the differential distribution of these mRNAs/proteins suggest that they perform distinct functions in vivo.
P J, Parker, G, Kour, R M, Marais, F, Mitchell, C, Pears, D, Schaap, S, Stabel, C, Webster   +7 more
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Rottlerin, a Novel Protein Kinase Inhibitor

Biochemical and Biophysical Research Communications, 1994
Rottlerin, a compound from Mallotus philippinensis, is shown to inhibit protein kinases with some specificity for PKC. To some extent, the novel inhibitor is able to differentiate between PKC isoenzymes, with IC50 values for PKC delta of 3-6 microM, PKC alpha,beta,gamma of 30-42 microM and PKC epsilon,eta,zeta of 80-100 microM.
M, Gschwendt, H J, Müller, K, Kielbassa, R, Zang, W, Kittstein, G, Rincke, F, Marks   +6 more
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Protein Kinase A and Chromosomal Stability

Annals of the New York Academy of Sciences, 2002
Abstract: All malignant human tumors contain chromosomal rearrangements. Among them, the majority of solid tumors show chromosomal instability, caused by abberations in chromosomal segregation during cell division. Chromosomal instability, defined as increased probability of formation of novel chromosomal mutations compared to that of normal or ...
Ludmila, Matyakhina, Sara M, Lenherr, Constantine A, Stratakis   +2 more
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Protein kinases 1988: a current perspective

The FASEB Journal, 1988
This review focuses on several recent developments in the field of protein kinases. In the area of protein serine/threonine kinases, much has been learned recently about protein kinase C structure and function. Novel lipid mediators, both stimulatory and inhibitory, have been discovered, and kinase has been shown to be an ...
P J, Blackshear, A C, Nairn, J F, Kuo
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Virulent Protein Kinase A

Science's STKE, 2007
The Yersinia Gram-negative bacteria are pathogenic to humans causing such diseases as bubonic plague. Through the action of a type III protein secretion system, Yersinia injects bacterial proteins necessary to subvert the host cell's normal processes and to promote bacterial survival and replication. Navarro
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