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Mechanisms of Protein Kinase A Anchoring
2010The second messenger cyclic adenosine monophosphate (cAMP), which is produced by adenylyl cyclases following stimulation of G-protein-coupled receptors, exerts its effect mainly through the cAMP-dependent serine/threonine protein kinase A (PKA). Due to the ubiquitous nature of the cAMP/PKA system, PKA signaling pathways underlie strict spatial and ...
Philipp, Skroblin +4 more
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British Journal of Pharmacology, 2014
The universal second messenger cAMP is generated upon stimulation of G(s) protein-coupled receptors, such as the (2)-adreneoceptor, and leads to the activation of PKA, the major cAMP effector protein. PKA oscillates between an on and off state and thereby regulates a plethora of distinct biological responses. The broad activation pattern of PKA and its
Poppinga, W. J. +3 more
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The universal second messenger cAMP is generated upon stimulation of G(s) protein-coupled receptors, such as the (2)-adreneoceptor, and leads to the activation of PKA, the major cAMP effector protein. PKA oscillates between an on and off state and thereby regulates a plethora of distinct biological responses. The broad activation pattern of PKA and its
Poppinga, W. J. +3 more
openaire +1 more source
Protein Kinases in Neutrophils: A Review
Membrane Biochemistry, 1989In chemotactic factor-stimulated neutrophils, rapid increases of intracellular levels of cyclic AMP, calcium, and diacylglycerol have been observed and may be linked to protein kinase activation. The study of the physiological role and regulation of protein kinases in the neutrophil and the identification of their substrates has provided valuable ...
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Protein kinase C: A memory kinase?
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1997openaire +2 more sources
Mechanisms, regulation and functions of the unfolded protein response
Nature Reviews Molecular Cell Biology, 2020Claudio Hetz +2 more
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Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing
Nature Reviews Molecular Cell Biology, 2021Simon Alberti, Anthony A Hyman
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The mechanisms of integral membrane protein biogenesis
Nature Reviews Molecular Cell Biology, 2021Ramanujan Shankar Hegde, Robert J Keenan
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Derivatization with fatty acids in peptide and protein drug discovery
Nature Reviews Drug Discovery, 2022Peter Kurtzhals +2 more
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