Results 1 to 10 of about 115,342,253 (257)

Crystal Structures Reveal Hidden Domain Mechanics in Protein Kinase A (PKA) [PDF]

Biology, 2023
Cyclic-AMP-dependent protein kinase A (PKA) is a critical enzyme involved in various signaling pathways that plays a crucial role in regulating cellular processes including metabolism, gene transcription, cell proliferation, and differentiation.
Colin L. Welsh, Abigail E. Conklin, Lalima K. Madan   +2 more
doaj   +2 more sources

cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits. [PDF]

J Biol Chem, 2019
Adame-García SR, Cervantes-Villagrana RD, Orduña-Castillo LB, Del Rio JC, Gutkind JS, Reyes-Cruz G, Taylor SS, Vázquez-Prado J.   +7 more
europepmc   +2 more sources

Phosphorylation of protein kinase A (PKA) regulatory subunit RIα by protein kinase G (PKG) primes PKA for catalytic activity in cells. [PDF]

J Biol Chem, 2018
Haushalter KJ, Casteel DE, Raffeiner A, Stefan E, Patel HH, Taylor SS.   +5 more
europepmc   +2 more sources

The Kinase Specificity of Protein Kinase Inhibitor Peptide

Frontiers in Pharmacology, 2021
G-protein-coupled-receptor (GPCR) signaling is exquisitely controlled to achieve spatial and temporal specificity. The endogenous protein kinase inhibitor peptide (PKI) confines the spatial and temporal spread of the activity of protein kinase A (PKA ...
Yao Chen, Yao Chen, Bernardo L. Sabatini
doaj   +1 more source

Protein Kinase Inhibitor Peptide as a Tool to Specifically Inhibit Protein Kinase A

Frontiers in Physiology, 2020
The protein kinase enzyme family plays a pivotal role in almost every aspect of cellular function, including cellular metabolism, division, proliferation, transcription, movement, and survival.
Chong Liu, Ping Ke, Jingjing Zhang, Xiaoying Zhang, Xiongwen Chen   +4 more
doaj   +1 more source

Potential and limitations of PKA/ PKG inhibitors for platelet studies

Platelets, 2022
Cyclic nucleotides (cAMP and cGMP) and corresponding protein kinases, protein kinase A (PKA) and protein kinase G (PKG), are the main intracellular mediators of endothelium-derived platelet inhibitors. Pharmacological PKA/PKG inhibitors are often used to
Valentina Shpakova, Natalia Rukoyatkina, Ulrich Walter, Stepan Gambaryan   +3 more
doaj   +1 more source

Acidosis Mediates the Switching of Gs-PKA and Gi-PKCε Dependence in Prolonged Hyperalgesia Induced by Inflammation. [PDF]

PLoS ONE, 2015
Chronic inflammatory pain, when not effectively treated, is a costly health problem and has a harmful effect on all aspects of health-related quality of life.
Wei-Yu Huang, Shih-Ping Dai, Yan-Ching Chang, Wei-Hsin Sun   +3 more
doaj   +1 more source

Transient Receptor Potential Vanilloid 1 Signaling Is Independent on Protein Kinase A Phosphorylation of Ankyrin-Rich Membrane Spanning Protein

Medical Sciences, 2022
The sensory ion channel transient receptor potential vanilloid 1 (TRPV1) is mainly expressed in small to medium sized dorsal root ganglion neurons, which are involved in the transfer of acute noxious thermal and chemical stimuli.
Antonio Pellegrino, Sandra Mükusch, Viola Seitz, Christoph Stein, Friedrich W. Herberg, Harald Seitz   +5 more
doaj   +1 more source

GABAC-Receptor Stimulation Activates cAMP-Dependent Protein Kinase via A-Kinase Anchoring Protein 220

Journal of Pharmacological Sciences, 2008
In our previous study, anti-apoptotic effects of GABAC-receptor stimulation was suppressed by inhibitors of cAMP-dependent protein kinase (PKA), implying GABACreceptor–mediated PKA activation. The present study showed that GABAC-receptor stimulation with
Li Yang, Yasuhisa Nakayama, Naoki Hattori, Bing Liu, Chiyoko Inagaki   +4 more
doaj   +1 more source

Prokaryotic expression of human-sourced and zebrafish-sourced protein kinase A alpha catalytic subunits combined with in vitro and in silico assay

Ecotoxicology and Environmental Safety, 2021
The extensively studied cAMP-dependent protein kinase A (PKA) is involved in the regulation of critical cell processes, including metabolism, gene expression, and cell proliferation.
Kun Qiao, Yao Jiang, Tiantian Hu, Shuying Li, Wenjun Gui   +4 more
doaj   +1 more source