Results 31 to 40 of about 79,392 (254)

New Aspects for the Treatment of Cardiac Diseases Based on the Diversity of Functional Controls on Cardiac Muscles: Mitochondrial Ion Channels and Cardioprotection

Journal of Pharmacological Sciences, 2009
Mitochondrial ATP-sensitive K+ (mitoKATP) and Ca2+-activated K+ (mitoKCa) channels exist in cardiac myocytes, and they play key roles in cardioprotection.
Hirofumi Nishida, Toshiaki Sato, Takehiko Ogura, Haruaki Nakaya   +3 more
doaj   +1 more source

Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A

eLife, 2020
In the nucleus, the spatiotemporal regulation of the catalytic subunit of cAMP-dependent protein kinase A (PKA-C) is orchestrated by an intrinsically disordered protein kinase inhibitor, PKI, which recruits the CRM1/RanGTP nuclear exporting complex.
Cristina Olivieri, Yingjie Wang, Geoffrey C Li, Manu V S, Jonggul Kim, Benjamin R Stultz, Matthew Neibergall, Fernando Porcelli, Joseph M Muretta, David DT Thomas, Jiali Gao, Donald K Blumenthal, Susan S Taylor, Gianluigi Veglia   +13 more
doaj   +1 more source

Comprehensive Analysis of Aspergillus nidulans PKA Phosphorylome Identifies a Novel Mode of CreA Regulation

mBio, 2019
In filamentous fungi, an important kinase responsible for adaptation to changes in available nutrients is cyclic AMP (cAMP)-dependent protein kinase (protein kinase A [PKA]).
Liliane F. C. Ribeiro, Cynthia Chelius, Karthik R. Boppidi, Nisha S. Naik, Simin Hossain, Jessica J. J. Ramsey, Jyothi Kumar, Lucas F. Ribeiro, Marc Ostermeier, Bao Tran, Young Ah Goo, Leandro J. de Assis, Mevlut Ulas, Ozgur Bayram, Gustavo H. Goldman, Stephen Lincoln, Ranjan Srivastava, Steven D. Harris, Mark R. Marten   +18 more
doaj   +1 more source

MAGI1 Mediates eNOS Activation and NO Production in Endothelial Cells in Response to Fluid Shear Stress

Cells, 2019
Fluid shear stress stimulates endothelial nitric oxide synthase (eNOS) activation and nitric oxide (NO) production through multiple kinases, including protein kinase A (PKA), AMP-activated protein kinase (AMPK), AKT and Ca2+/calmodulin-dependent protein ...
Kedar Ghimire, Jelena Zaric, Begoña Alday-Parejo, Jochen Seebach, Mélanie Bousquenaud, Jimmy Stalin, Grégory Bieler, Hans-Joachim Schnittler, Curzio Rüegg   +8 more
doaj   +1 more source

Protein Kinase A in cellular migration—Niche signaling of a ubiquitous kinase

Frontiers in Molecular Biosciences, 2022
Cell migration requires establishment and maintenance of directional polarity, which in turn requires spatial heterogeneity in the regulation of protrusion, retraction, and adhesion.
Kathryn V. Svec, Alan K. Howe, Alan K. Howe, Alan K. Howe   +3 more
doaj   +1 more source

Unveiling Protein Kinase A Targets in Cryptococcus neoformans Capsule Formation

mBio, 2016
The protein kinase A (PKA) signal transduction pathway has been associated with pathogenesis in many fungal species. Geddes and colleagues [mBio 7(1):e01862-15, 2016, doi:10.1128/mBio.01862-15] used quantitative proteomics approaches to define proteins ...
J. Andrew Alspaugh
doaj   +1 more source

Compartmentalization Role of A-Kinase Anchoring Proteins (AKAPs) in Mediating Protein Kinase A (PKA) Signaling and Cardiomyocyte Hypertrophy [PDF]

International Journal of Molecular Sciences, 2014
The Beta-adrenergic receptors (β-ARs) stimulation enhances contractility through protein kinase-A (PKA) substrate phosphorylation. This PKA signaling is conferred in part by PKA binding to A-kinase anchoring proteins (AKAPs). AKAPs coordinate multi-protein signaling networks that are targeted to specific intracellular locations, resulting in the ...
Abeer Rababa'h, Sonal Singh, Santosh Suryavanshi, Salah Altarabsheh, Salil Deo, Bradley McConnell   +5 more
openaire   +2 more sources

Beta-adrenergic agonist protects retinal pigment epithelium against hydroxycholoroquine toxicity via cAMP-PKA signal pathway [PDF]

International Journal of Ophthalmology, 2020
AIM: To test our hypothesis that activation of protein kinase A (PKA) signal pathway by β-adrenergic agonist plays an important role in the protecting of cultured retinal pigment epithelial (RPE) cells against the hydroxychloroquine (HCQ) toxicity ...
Ruihua Zhang, Dan-Ning Hu, Richard Rosen
doaj   +1 more source

Gabapentin activates ROMK1 channels by a protein kinase A (PKA)‐dependent mechanism [PDF]

British Journal of Pharmacology, 2008
Background and purpose:Gabapentin is an effective anticonvulsant. The major physiological function of renal outer medullary potassium (ROMK1) channels is to maintain the resting membrane potential (RMP). We investigated the effect of gabapentin on ROMK1 channels and the mechanism involved.Experimental approach:Xenopusoocytes were injected with mRNA ...
C-H, Lee, T-S, Tsai, H-H, Liou
openaire   +2 more sources

Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins

Frontiers in Pharmacology, 2015
Cyclic AMP is a ubiquitous intracellular second messenger involved in the regulation of a wide variety of cellular processes, a majority of which act through the cAMP - protein kinase A (PKA) signalling pathway and involve PKA phosphorylation of specific
Ana Isabel C. Calejo, Kjetil eTaskén
doaj   +1 more source