Phosphorylation of protein kinase A (PKA) regulatory subunit RIα by protein kinase G (PKG) primes PKA for catalytic activity in cells [PDF]
Journal of Biological Chemistry, 2018 cAMP-dependent protein kinase (PKAc) is a pivotal signaling protein in eukaryotic cells. PKAc has two well-characterized regulatory subunit proteins, RI and RII (each having α and β isoforms), which keep the PKAc catalytic subunit in a catalytically ...
Darren E Casteel +2 more
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Crystal Structures Reveal Hidden Domain Mechanics in Protein Kinase A (PKA) [PDF]
Biology, 2023 Cyclic-AMP-dependent protein kinase A (PKA) is a critical enzyme involved in various signaling pathways that plays a crucial role in regulating cellular processes including metabolism, gene transcription, cell proliferation, and differentiation.
Colin L. Welsh +2 more
doaj +4 more sources
Evolution of the cAMP-dependent protein kinase (PKA) catalytic subunit isoforms. [PDF]
PLoS ONE, 2017 The 3',5'-cyclic adenosine monophosphate (cAMP)-dependent protein kinase, or protein kinase A (PKA), pathway is one of the most versatile and best studied signaling pathways in eukaryotic cells.
Kristoffer Søberg +3 more
doaj +5 more sources
Characterizing protein kinase A (PKA) subunits as macromolecular regulators of PKA RIα liquid-liquid phase separation. [PDF]
J Chem Phys, 2021 Researchers developed a method called fast Fourier transform (FFT)-based modeling of atomistic protein–protein interactions applied to cross second virial coefficient B23(FMAPB23) to characterize protein kinase A (PKA) subunits as macromolecular regulators of PKA RIα liquid-liquid phase separation. The cross second virial coefficient B23 was calculated
Ahn SH +5 more
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Functional Insights into Protein Kinase A (PKA) Signaling from C. elegans. [PDF]
Life (Basel), 2022 Protein kinase A (PKA), which regulates a diverse set of biological functions downstream of cyclic AMP (cAMP), is a tetramer consisting of two catalytic subunits (PKA-C) and two regulatory subunits (PKA-R). When cAMP binds the PKA-R subunits, the PKA-C subunits are released and interact with downstream effectors. In Caenorhabditis elegans (C. elegans),
Sadeghian F +3 more
europepmc +4 more sources
PKA and PKC signaling pathways mediate vitamin D₃-regulated intestinal phosphorus absorption in broiler chickens [PDF]
Poultry ScienceThree experiments were conducted to investigate the functional roles of the protein kinase A (PKA) and protein kinase C (PKC) signaling pathways in vitamin D₃ (VD₃)-regulated intestinal phosphorus (P) absorption in broiler chickens. Experiment 1 examined
Mengyuan Liu +11 more
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cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits [PDF]
Journal of Biological Chemistry, 2019 Sendi Rafael Adame-Garcia +2 more
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The Kinase Specificity of Protein Kinase Inhibitor Peptide
Frontiers in Pharmacology, 2021 G-protein-coupled-receptor (GPCR) signaling is exquisitely controlled to achieve spatial and temporal specificity. The endogenous protein kinase inhibitor peptide (PKI) confines the spatial and temporal spread of the activity of protein kinase A (PKA ...
Yao Chen, Yao Chen, Bernardo L. Sabatini
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Potential and limitations of PKA/ PKG inhibitors for platelet studies
Platelets, 2022 Cyclic nucleotides (cAMP and cGMP) and corresponding protein kinases, protein kinase A (PKA) and protein kinase G (PKG), are the main intracellular mediators of endothelium-derived platelet inhibitors. Pharmacological PKA/PKG inhibitors are often used to
Valentina Shpakova +3 more
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Protein Kinase A(PKA)-Restrictcive and PKA-Permissive Phases of Oocyte Maturation [PDF]
Cell Cycle, 2005 Substantial evidence has indicated that cAMP-dependent protein kinase (protein kinase A or PKA) plays a critical role in maintaining meiotic prophase arrest in vertebrate oocytes. However, PKA activity dynamic and its physiological substrate profile during oocyte maturation remain poorly defined.
Jing, Wang +2 more
openaire +2 more sources