Results 11 to 20 of about 79,392 (254)
Protein Kinase Inhibitor Peptide as a Tool to Specifically Inhibit Protein Kinase A
Frontiers in Physiology, 2020 The protein kinase enzyme family plays a pivotal role in almost every aspect of cellular function, including cellular metabolism, division, proliferation, transcription, movement, and survival.
Chong Liu +4 more
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Potential and limitations of PKA/ PKG inhibitors for platelet studies
Platelets, 2022 Cyclic nucleotides (cAMP and cGMP) and corresponding protein kinases, protein kinase A (PKA) and protein kinase G (PKG), are the main intracellular mediators of endothelium-derived platelet inhibitors. Pharmacological PKA/PKG inhibitors are often used to
Valentina Shpakova +3 more
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Protein Kinase A(PKA)-Restrictcive and PKA-Permissive Phases of Oocyte Maturation [PDF]
Cell Cycle, 2005 Substantial evidence has indicated that cAMP-dependent protein kinase (protein kinase A or PKA) plays a critical role in maintaining meiotic prophase arrest in vertebrate oocytes. However, PKA activity dynamic and its physiological substrate profile during oocyte maturation remain poorly defined.
Jing, Wang +2 more
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Protein Kinase A (PKA)- and Protein Kinase C-phosphorylated Glia Maturation Factor Promotes the Catalytic Activity of PKA [PDF]
Journal of Biological Chemistry, 1997 We observed previously that glia maturation factor (GMF), a 17-kDa brain protein, is rapidly phosphorylated in astrocytes following stimulation by phorbol ester, and that protein kinase A (PKA)-phosphorylated GMF is a potent inhibitor of extracellular signal-regulated kinase (ERK) and enhancer of p38; both are subfamilies of mitogen-activated protein ...
A, Zaheer, R, Lim
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Acidosis Mediates the Switching of Gs-PKA and Gi-PKCε Dependence in Prolonged Hyperalgesia Induced by Inflammation. [PDF]
PLoS ONE, 2015 Chronic inflammatory pain, when not effectively treated, is a costly health problem and has a harmful effect on all aspects of health-related quality of life.
Wei-Yu Huang +3 more
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Medical Sciences, 2022 The sensory ion channel transient receptor potential vanilloid 1 (TRPV1) is mainly expressed in small to medium sized dorsal root ganglion neurons, which are involved in the transfer of acute noxious thermal and chemical stimuli.
Antonio Pellegrino +5 more
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Vasopressin Induces Urinary Uromodulin Secretion By Activating PKA (Protein Kinase A) [PDF]
Hypertension, 2021 Urinary uromodulin, secreted by renal tubular cells, protects against urinary tract infections and kidney stones. In contrast, the intracellular accumulation of uromodulin is associated with hypertension and chronic kidney disease. However, the physiological stimuli for urinary uromodulin secretion remain largely unknown.
Azuma Nanamatsu +8 more
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The Dictyostelium Mitogen-activated Protein Kinase ERK2 Is Regulated by Ras and cAMP-dependent Protein Kinase (PKA) and Mediates PKA Function [PDF]
Journal of Biological Chemistry, 1997 The chemoattractant cAMP, acting through serpentine cAMP receptors, results in a rapid and transient stimulation of the Dictyostelium mitogen-activated protein kinase ERK2 activity (). In this study we show that other pathways required for aggregation, including Ras and cAMP-dependent protein kinase (PKA), are important regulators of ERK2 activation ...
L, Aubry +4 more
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Journal of Pharmacological Sciences, 2008 In our previous study, anti-apoptotic effects of GABAC-receptor stimulation was suppressed by inhibitors of cAMP-dependent protein kinase (PKA), implying GABACreceptor–mediated PKA activation. The present study showed that GABAC-receptor stimulation with
Li Yang +4 more
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Ecotoxicology and Environmental Safety, 2021 The extensively studied cAMP-dependent protein kinase A (PKA) is involved in the regulation of critical cell processes, including metabolism, gene expression, and cell proliferation.
Kun Qiao +4 more
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