Results 21 to 30 of about 79,392 (254)

Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms

eLife, 2023
Genetic alterations that activate protein kinase A (PKA) are found in many tumor types. Yet, their downstream oncogenic signaling mechanisms are poorly understood.
Gary KL Chan, Samantha Maisel, Yeonjoo C Hwang, Bryan C Pascual, Rebecca RB Wolber, Phuong Vu, Krushna C Patra, Mehdi Bouhaddou, Heidi L Kenerson, Huat C Lim, Donald Long, Raymond S Yeung, Praveen Sethupathy, Danielle L Swaney, Nevan J Krogan, Rigney E Turnham, Kimberly J Riehle, John D Scott, Nabeel Bardeesy, John D Gordan   +19 more
doaj   +1 more source

Liberated PKA Catalytic Subunits Associate with the Membrane via Myristoylation to Preferentially Phosphorylate Membrane Substrates

Cell Reports, 2017
Summary: Protein kinase A (PKA) has diverse functions in neurons. At rest, the subcellular localization of PKA is controlled by A-kinase anchoring proteins (AKAPs). However, the dynamics of PKA upon activation remain poorly understood.
Shane E. Tillo, Wei-Hong Xiong, Maho Takahashi, Sheng Miao, Adriana L. Andrade, Dale A. Fortin, Guang Yang, Maozhen Qin, Barbara F. Smoody, Philip J.S. Stork, Haining Zhong   +10 more
doaj   +1 more source

Molecular Basis for Ser/Thr Specificity in PKA Signaling

Cells, 2020
cAMP-dependent protein kinase (PKA) is the major receptor of the second messenger cAMP and a prototype for Ser/Thr-specific protein kinases. Although PKA strongly prefers serine over threonine substrates, little is known about the molecular basis of this
Matthias J. Knape, Maximilian Wallbott, Nicole C. G. Burghardt, Daniela Bertinetti, Jan Hornung, Sven H. Schmidt, Robin Lorenz, Friedrich W. Herberg   +7 more
doaj   +1 more source

c-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-Cβ) gene [PDF]

Oncogene, 2002
The c-MYC proto-oncogene encodes a ubiquitous transcription factor involved in the control of cell growth and differentiation and broadly implicated in tumorigenesis. Understanding the function of c-MYC and its role in cancer depends upon the identification of c-MYC target genes. Here we show that c-MYC induces the activity of Protein Kinase A (PKA), a
Kou-Juey, Wu, Michela, Mattioli, Herbert C, Morse, Riccardo, Dalla-Favera   +3 more
openaire   +2 more sources

The RIα subunit of protein kinase A (PKA) binds to Grb2 and allows PKA interaction with the activated EGF-Receptor [PDF]

Oncogene, 1997
Functional interactions between protein kinase A (PKA) and epidermal growth factor receptor (EGF-R) signalling pathways have been suggested. Unlike the type II isoform of PKA (PKAII), the type I (PKAI) and/or its regulatory subunit RIalpha are generally overexpressed in cancer cells and are induced following transforming growth factor alpha (TGF alpha)/
TORTORA G, DAMIANO V, BIANCO C, BALDASSARRE G, BIANCO AR, LANFRANCONE L, PELICCI PG, CIARDIELLO, Fortunato   +7 more
openaire   +5 more sources

Defining A‐Kinase Anchoring Protein (AKAP) Specificity for the Protein Kinase A Subunit RI (PKA‐RI) [PDF]

ChemBioChem, 2015
AbstractA‐Kinase anchoring proteins (AKAPs) act as spatial and temporal regulators of protein kinase A (PKA) by localizing PKA along with multiple proteins into discrete signaling complexes. AKAPs interact with the PKA holoenzyme through an α‐helix that docks into a groove formed on the dimerization/docking domain of PKA‐R in an isoform‐dependent ...
Karolin, Autenrieth, N George, Bendzunas, Daniela, Bertinetti, Friedrich W, Herberg, Eileen J, Kennedy   +4 more
openaire   +2 more sources

Correlation of Human Protein Kinase a (PKA) and G-Glycoprotein in Patients with T2DM

Medical Journal of Babylon, 2021
Background: Type 2 diabetes usually starts with insulin resistance—a condition that happens when muscle, fat, and liver cells cannot use insulin to deliver glucose into the cells of the body for energy use. Materials and Methods: The group subjected to this study consists of 45 type
Sura S Khadhim, Maha F Smaism, Ali Albayati   +2 more
openaire   +2 more sources

Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4

Journal of Neuroinflammation, 2018
Background Evidence indicates a cross-regulation between two kinases, leucine-rich repeat kinase 2 (LRRK2) and protein kinase A (PKA). In neurons, LRRK2 negatively regulates PKA activity in spiny projecting neurons during synaptogenesis and in response ...
Isabella Russo, Giulietta Di Benedetto, Alice Kaganovich, Jinhui Ding, Daniela Mercatelli, Michele Morari, Mark R. Cookson, Luigi Bubacco, Elisa Greggio   +8 more
doaj   +1 more source

Activation of PKA via asymmetric allosteric coupling of structurally conserved cyclic nucleotide binding domains

Nature Communications, 2019
Protein kinase A (PKA) is a cyclic nucleotide dependent protein kinase. Here the authors use single molecule optical tweezers and steered molecular dynamic simulations to follow in real time and quantitatively characterize the signals transduced by cAMP ...
Yuxin Hao, Jeneffer P. England, Luca Bellucci, Emanuele Paci, H. Courtney Hodges, Susan S. Taylor, Rodrigo A. Maillard   +6 more
doaj   +1 more source

Functional mapping of protein kinase A reveals its importance in adult Schistosoma mansoni motor activity.

PLoS Neglected Tropical Diseases, 2013
Cyclic AMP (cAMP)-dependent protein kinase/protein kinase A (PKA) is the major transducer of cAMP signalling in eukaryotic cells. Here, using laser scanning confocal microscopy and 'smart' anti-phospho PKA antibodies that exclusively detect activated PKA,
Paulu S R de Saram, Margarida Ressurreição, Angela J Davies, David Rollinson, Aidan M Emery, Anthony J Walker   +5 more
doaj   +1 more source