Results 21 to 30 of about 145,066 (299)
Protein Kinase Inhibitor Peptide as a Tool to Specifically Inhibit Protein Kinase A
Frontiers in Physiology, 2020 The protein kinase enzyme family plays a pivotal role in almost every aspect of cellular function, including cellular metabolism, division, proliferation, transcription, movement, and survival.
Chong Liu +4 more
doaj +1 more source
Protein Kinase A (PKA)- and Protein Kinase C-phosphorylated Glia Maturation Factor Promotes the Catalytic Activity of PKA [PDF]
Journal of Biological Chemistry, 1997 We observed previously that glia maturation factor (GMF), a 17-kDa brain protein, is rapidly phosphorylated in astrocytes following stimulation by phorbol ester, and that protein kinase A (PKA)-phosphorylated GMF is a potent inhibitor of extracellular signal-regulated kinase (ERK) and enhancer of p38; both are subfamilies of mitogen-activated protein ...
A, Zaheer, R, Lim
openaire +2 more sources
Vasopressin Induces Urinary Uromodulin Secretion By Activating PKA (Protein Kinase A) [PDF]
Hypertension, 2021 Urinary uromodulin, secreted by renal tubular cells, protects against urinary tract infections and kidney stones. In contrast, the intracellular accumulation of uromodulin is associated with hypertension and chronic kidney disease. However, the physiological stimuli for urinary uromodulin secretion remain largely unknown.
Azuma Nanamatsu +8 more
openaire +2 more sources
Acidosis Mediates the Switching of Gs-PKA and Gi-PKCε Dependence in Prolonged Hyperalgesia Induced by Inflammation. [PDF]
PLoS ONE, 2015 Chronic inflammatory pain, when not effectively treated, is a costly health problem and has a harmful effect on all aspects of health-related quality of life.
Wei-Yu Huang +3 more
doaj +1 more source
Medical Sciences, 2022 The sensory ion channel transient receptor potential vanilloid 1 (TRPV1) is mainly expressed in small to medium sized dorsal root ganglion neurons, which are involved in the transfer of acute noxious thermal and chemical stimuli.
Antonio Pellegrino +5 more
doaj +1 more source
The Dictyostelium Mitogen-activated Protein Kinase ERK2 Is Regulated by Ras and cAMP-dependent Protein Kinase (PKA) and Mediates PKA Function [PDF]
Journal of Biological Chemistry, 1997 The chemoattractant cAMP, acting through serpentine cAMP receptors, results in a rapid and transient stimulation of the Dictyostelium mitogen-activated protein kinase ERK2 activity (). In this study we show that other pathways required for aggregation, including Ras and cAMP-dependent protein kinase (PKA), are important regulators of ERK2 activation ...
L, Aubry +4 more
openaire +2 more sources
Journal of Pharmacological Sciences, 2008 In our previous study, anti-apoptotic effects of GABAC-receptor stimulation was suppressed by inhibitors of cAMP-dependent protein kinase (PKA), implying GABACreceptor–mediated PKA activation. The present study showed that GABAC-receptor stimulation with
Li Yang +4 more
doaj +1 more source
Ecotoxicology and Environmental Safety, 2021 The extensively studied cAMP-dependent protein kinase A (PKA) is involved in the regulation of critical cell processes, including metabolism, gene expression, and cell proliferation.
Kun Qiao +4 more
doaj +1 more source
Reciprocal regulation of PKA and rac signaling [PDF]
, 2013 Activated G protein-coupled receptors (GPCRs) and receptor tyrosine kinases relay extracellular signals through spatial and temporal controlled kinase and GTPase entities.
A. Riml +47 more
core +1 more source
c-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-Cβ) gene [PDF]
Oncogene, 2002 The c-MYC proto-oncogene encodes a ubiquitous transcription factor involved in the control of cell growth and differentiation and broadly implicated in tumorigenesis. Understanding the function of c-MYC and its role in cancer depends upon the identification of c-MYC target genes. Here we show that c-MYC induces the activity of Protein Kinase A (PKA), a
Kou-Juey, Wu +3 more
openaire +2 more sources