A-Kinase Anchoring Protein 2 Promotes Protection against Myocardial Infarction [PDF]
Cells, 2021 Myocardial infarction (MI) is a leading cause of maladaptive cardiac remodeling and heart failure. In the damaged heart, loss of function is mainly due to cardiomyocyte death and remodeling of the cardiac tissue.
Darko Maric +5 more
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A-Kinase Anchoring Protein-Lbc: A Molecular Scaffold Involved in Cardiac Protection [PDF]
Journal of Cardiovascular Development and Disease, 2018 Heart failure is a lethal disease that can develop after myocardial infarction, hypertension, or anticancer therapy. In the damaged heart, loss of function is mainly due to cardiomyocyte death and associated cardiac remodeling and fibrosis.
Dario Diviani, Halima Osman, Erica Reggi
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Role of A-Kinase Anchoring Protein 1 in Retinal Ganglion Cells: Neurodegeneration and Neuroprotection [PDF]
Cells, 2023 A-Kinase anchoring protein 1 (AKAP1) is a multifunctional mitochondrial scaffold protein that regulates mitochondrial dynamics, bioenergetics, and calcium homeostasis by anchoring several proteins, including protein kinase A, to the outer mitochondrial ...
Tonking Bastola +7 more
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Protein Kinase A Regulates Platelet Phosphodiesterase 3A through an A-Kinase Anchoring Protein Dependent Manner [PDF]
CellsPlatelet activation is critical for haemostasis, but if unregulated can lead to pathological thrombosis. Endogenous platelet inhibitory mechanisms are mediated by prostacyclin (PGI2)-stimulated cAMP signalling, which is regulated by phosphodiesterase 3A (
Jawad S. Khalil +7 more
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A-kinase anchoring protein 1: an independent predictor of coronary artery disease [PDF]
BMC Cardiovascular DisordersIntroduction Coronary artery disease (CAD) is the leading cause of death worldwide. A-kinase anchoring protein 1 (AKAP1), thought to regulate the function and structure of mitochondria, is enriched in the heart, where it plays a protective role. However,
Wei Yan, Yun-Lang Dai, Jun-Xia Han
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Characterization of a Protein Phosphatase Type-1 and a Kinase Anchoring Protein in Plasmodium falciparum [PDF]
Frontiers in Microbiology, 2018 With its multiple regulatory partners, the conserved Protein Phosphatase type-1 (PP1) plays a central role in many functions of the biology of eukaryotic cells, including Plasmodium falciparum. Here, we characterized a protein named PfRCC-PIP, as a major
Astrid Lenne +9 more
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Cypher/ZASP is a novel A-kinase anchoring protein. [PDF]
J Biol Chem, 2013 PKA signaling is important for the post-translational modification of proteins, especially those in cardiomyocytes involved in cardiac excitation-contraction coupling. PKA activity is spatially and temporally regulated through compartmentalization by protein kinase A anchoring proteins.
Lin C +13 more
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A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells [PDF]
Nature Communications, 2017 BIG3 is highly expressed in breast cancers and its interaction with PHB2 results in constitutive activation of E2/ERa signalling. Here the authors unveil the mechanistic details of this regulation showing that BIG3 binds PKA and regulates PP1Ca activity ...
Tetsuro Yoshimaru +12 more
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A Novel A‐Kinase‐Anchoring Protein 9 Variant in Premature Coronary Artery Disease: A Case Series [PDF]
Molecular Genetics & Genomic MedicineBackground Familial premature coronary artery disease (CAD) is often associated with genetic variants. This study investigated potential causal variants in a Chinese pedigree with premature CAD.
Yuemiao Jiao +7 more
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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function [PDF]
Neural Regeneration ResearchWilliam J. Flerlage +3 more
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