Results 31 to 40 of about 38,040 (251)
Frontiers in Physiology, 2020 Our understanding of the general principles of the polymodal regulation of transient receptor potential (TRP) ion channels has grown impressively in recent years as a result of intense efforts in protein structure determination by cryo-electron ...
Lucie Zimova +8 more
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A-kinase anchoring in dendritic cells is required for antigen presentation. [PDF]
PLoS ONE, 2009 BACKGROUND: Dendritic cells (DC) are the most potent antigen presenting cells (APC) of the immune system. Prostaglandin E(2), cyclic AMP, and protein kinase A (PKA) have all been shown to regulate DC maturation and activity.
Robynn V Schillace +6 more
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AKAP6 and phospholamban colocalize and interact in HEK‐293T cells and primary murine cardiomyocytes
Physiological Reports, 2019 Phospholamban (PLN) is an important Ca2+ modulator at the sarcoplasmic reticulum (SR) of striated muscles. It physically interacts and inhibits sarcoplasmic reticulum Ca2+ ATPase (SERCA2) function, whereas a protein kinase A (PKA)‐dependent ...
Farigol Hakem Zadeh +5 more
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The Role of Cyclic AMP Signaling in Cardiac Fibrosis
Cells, 2019 Myocardial stress and injury invariably promote remodeling of the cardiac tissue, which is associated with cardiomyocyte death and development of fibrosis. The fibrotic process is initially triggered by the differentiation of resident cardiac fibroblasts
Marion Delaunay +3 more
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Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella
Reproductive Biology and Endocrinology, 2004 Background Sperm protein 17 (Sp17) is a three-domain protein that contains: 1) a highly conserved N-terminal domain that is 45% identical to the human type II alpha regulatory subunit (RII alpha) of protein kinase A (PKA); 2) a central sulphated ...
O'Rand Michael G +2 more
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Spoonbill positively regulates JNK signalling mediated apoptosis in Drosophila melanogaster
European Journal of Cell Biology, 2023 A-kinase anchoring protein (AKAP) comprises a family of scaffold proteins, which decides the subcellular localisation of a combination of signalling molecules. Spoonbill (Spoon) is a putative A-kinase anchoring protein in Drosophila.
Rituparna Das +6 more
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Identification of FAM53C as a cytosolic-anchoring inhibitory binding protein of the kinase DYRK1A
Life Science Alliance, 2023 A previously uncharacterized protein, FAM53C, is identified as a binding partner for the kinase DYRK1A involved in numerous neurodevelopmental disorders, such as Down syndrome and autism spectrum disorder.
Yoshihiko Miyata, Eisuke Nishida
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A-kinase anchoring proteins: scaffolding proteins in the heart
American Journal of Physiology-Heart and Circulatory Physiology, 2011 The pleiotropic cyclic nucleotide cAMP is the primary second messenger responsible for autonomic regulation of cardiac inotropy, chronotropy, and lusitropy. Under conditions of prolonged catecholaminergic stimulation, cAMP also contributes to the induction of both cardiac myocyte hypertrophy and apoptosis.
Diviani Dario +3 more
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Cell Reports, 2014 L-type voltage-gated Ca2+ channels (LTCC) couple neuronal excitation to gene transcription. LTCC activity is elevated by the cyclic AMP (cAMP)-dependent protein kinase (PKA) and depressed by the Ca2+-dependent phosphatase calcineurin (CaN), and both ...
Jonathan G. Murphy +6 more
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A-Kinase Anchoring Protein Targeting of Protein Kinase A and Regulation of HERG Channels [PDF]
Journal of Membrane Biology, 2008 Adrenergic stimulation of the heart initiates a signaling cascade in cardiac myocytes that increases the concentration of cAMP. Although cAMP elevation may occur over a large area of a target-organ cell, its effects are often more restricted due to local concentration of its main effector, protein kinase A (PKA), through A-kinase anchoring proteins ...
Li, Yan +3 more
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