Results 31 to 40 of about 115,303,296 (139)
Polymorphisms/Mutations in A-Kinase Anchoring Proteins (AKAPs): Role in the Cardiovascular System
Journal of Cardiovascular Development and Disease, 2018 A-kinase anchoring proteins (AKAPs) belong to a family of scaffolding proteins that bind to protein kinase A (PKA) by definition and a variety of crucial proteins, including kinases, phosphatases, and phosphodiesterases.
Santosh V. Suryavanshi +2 more
doaj +1 more source
Frontiers in Physiology, 2020 Our understanding of the general principles of the polymodal regulation of transient receptor potential (TRP) ion channels has grown impressively in recent years as a result of intense efforts in protein structure determination by cryo-electron ...
Lucie Zimova +8 more
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A-kinase anchoring in dendritic cells is required for antigen presentation. [PDF]
PLoS ONE, 2009 BACKGROUND: Dendritic cells (DC) are the most potent antigen presenting cells (APC) of the immune system. Prostaglandin E(2), cyclic AMP, and protein kinase A (PKA) have all been shown to regulate DC maturation and activity.
Robynn V Schillace +6 more
doaj +1 more source
AKAP6 and phospholamban colocalize and interact in HEK‐293T cells and primary murine cardiomyocytes
Physiological Reports, 2019 Phospholamban (PLN) is an important Ca2+ modulator at the sarcoplasmic reticulum (SR) of striated muscles. It physically interacts and inhibits sarcoplasmic reticulum Ca2+ ATPase (SERCA2) function, whereas a protein kinase A (PKA)‐dependent ...
Farigol Hakem Zadeh +5 more
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The Role of Cyclic AMP Signaling in Cardiac Fibrosis
Cells, 2019 Myocardial stress and injury invariably promote remodeling of the cardiac tissue, which is associated with cardiomyocyte death and development of fibrosis. The fibrotic process is initially triggered by the differentiation of resident cardiac fibroblasts
Marion Delaunay +3 more
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Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella
Reproductive Biology and Endocrinology, 2004 Background Sperm protein 17 (Sp17) is a three-domain protein that contains: 1) a highly conserved N-terminal domain that is 45% identical to the human type II alpha regulatory subunit (RII alpha) of protein kinase A (PKA); 2) a central sulphated ...
O'Rand Michael G +2 more
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Identification of FAM53C as a cytosolic-anchoring inhibitory binding protein of the kinase DYRK1A
Life Science Alliance, 2023 A previously uncharacterized protein, FAM53C, is identified as a binding partner for the kinase DYRK1A involved in numerous neurodevelopmental disorders, such as Down syndrome and autism spectrum disorder.
Yoshihiko Miyata, Eisuke Nishida
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Control of PKA stability and signalling by RING ligase praja2 [PDF]
, 2010 Ligand-mediated activation of G-Protein Coupled Receptors (GPCRs) mobilises compartmentalised pulses of second messengers like cAMP. The main cellular effector of cAMP is Protein Kinase A (PKA) which is assembled as inactive holoenzyme consisting of two ...
Lignitto, Luca
core +1 more source
Cell Reports, 2014 L-type voltage-gated Ca2+ channels (LTCC) couple neuronal excitation to gene transcription. LTCC activity is elevated by the cyclic AMP (cAMP)-dependent protein kinase (PKA) and depressed by the Ca2+-dependent phosphatase calcineurin (CaN), and both ...
Jonathan G. Murphy +6 more
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Spoonbill positively regulates JNK signalling mediated apoptosis in Drosophila melanogaster
European Journal of Cell Biology, 2023 A-kinase anchoring protein (AKAP) comprises a family of scaffold proteins, which decides the subcellular localisation of a combination of signalling molecules. Spoonbill (Spoon) is a putative A-kinase anchoring protein in Drosophila.
Rituparna Das +6 more
doaj +1 more source