Results 51 to 60 of about 115,303,296 (139)

Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase [PDF]

, 2012
eEF2K [eEF2 (eukaryotic elongation factor 2) kinase] phosphorylates and inactivates the translation elongation factor eEF2. eEF2K is not a member of the main eukaryotic protein kinase superfamily, but instead belongs to a small group of so-called ...
Hussain, Nusrat, Proud, Christopher G, Proud, C., Wang, Xuemin, Rider, M., Rider, Mark H, Pyr Dit Ruys, S., Vertommen, D., Rider, Mark, Pyr Dit Ruys, Sébastien, Herinckx, Gaëtan, Vertommen, Didier, Herinckx, G., Smith, Ewan M, Wang, X., Smith, E., Hussain, N.   +16 more
core   +1 more source

Phosphodiesterase 4 cAMP phosphodiesterases as targets for novel anti-inflammatory therapeutics

Allergology International, 2004
Cyclic nucleotides are powerful signaling molecules and their sole means of removal is through the action of cyclic nucleotide phosphodiesterases (PDEs). Elevating levels of cAMP is beneficial in many diseases, including neurological conditions, cancers,
Simon J MacKenzie
doaj   +1 more source

Disruption of AKAP-PKA Interaction Induces Hypercontractility With Concomitant Increase in Proliferation Markers in Human Airway Smooth Muscle

Frontiers in Cell and Developmental Biology, 2020
With the ability to switch between proliferative and contractile phenotype, airway smooth muscle (ASM) cells can contribute to the progression of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), in which airway obstruction
Hoeke A. Baarsma, Hoeke A. Baarsma, Bing Han, Bing Han, Wilfred J. Poppinga, Wilfred J. Poppinga, Saskia Driessen, Carolina R. S. Elzinga, Andrew J. Halayko, Herman Meurs, Herman Meurs, Harm Maarsingh, Martina Schmidt, Martina Schmidt   +13 more
doaj   +1 more source

Chromodomain helicase binding protein 8 (Chd8) is a novel A-kinase anchoring protein expressed during rat cardiac development. [PDF]

PLoS ONE, 2012
A-kinase anchoring proteins (AKAPs) bind the regulatory subunits of protein kinase A (PKA) and localize the holoenzyme to discrete signaling microdomains in multiple subcellular compartments.
Maureen O Shanks, Linda M Lund, Sabrina Manni, Mary Russell, Joseph R H Mauban, Meredith Bond   +5 more
doaj   +1 more source

GABA(A) receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein [PDF]

, 2004
GABA(A) receptors are critical in controlling neuronal activity. Here, we examined the role for phospholipase C-related inactive protein type 1 (PRIP-1), which binds and inactivates protein phosphatase 1alpha (PP1alpha) in facilitating GABA(A) receptor ...
Kanematsu, T, Terunuma, M, Jovanovic, JN, Jang, IS, Kittler, JT, Akaike, N, Nakayama, KI, Ryu, SH, Moss, SJ, Ha, SH, Hirata, M   +10 more
core  

Protein kinase D enzymes are dispensable for proliferation, survival and antigen receptor-regulated NFκB activity in vertebrate B-cells [PDF]

, 2007
To investigate the importance of protein kinase D (PKD) enzymes we generated a PKD-null DT40 B-lymphocyte cell line. Previously we have shown that PKDs have an essential role in regulating class II histone deacetylases in DT40 B-cells [Matthews, S.A ...
Scharenberg, Andrew M., Cantrell, Doreen A., Liu, Ping, Matthews, Sharon A.   +3 more
core   +1 more source

Functional and Structural Mimicry of Cellular Protein Kinase A Anchoring Proteins by a Viral Oncoprotein. [PDF]

PLoS Pathogens, 2016
The oncoproteins of the small DNA tumor viruses interact with a plethora of cellular regulators to commandeer control of the infected cell. During infection, adenovirus E1A deregulates cAMP signalling and repurposes it for activation of viral gene ...
Cason R King, Michael J Cohen, Gregory J Fonseca, Brennan S Dirk, Jimmy D Dikeakos, Joe S Mymryk   +5 more
doaj   +1 more source

Functional analysis of the "Saccharomyces cerevisiae" Npr1 protein kinase [PDF]

, 2007
The uptake and processing of nutrients is highly regulated. Cells adapt to changes of the availability of nutrients to provide a complete set of transporters and metabolizing enzymes for optimal use of the available nutrients.
Gander, Stefan
core   +1 more source

A novel protein kinase-like domain in a selenoprotein, widespread in the tree of life. [PDF]

, 2012
Selenoproteins serve important functions in many organisms, usually providing essential oxidoreductase enzymatic activity, often for defense against toxic xenobiotic substances.
Dudkiewicz, Małgorzata, Grynberg, Marcin, Pawłowski, Krzysztof, Szczepińska, Teresa   +3 more
core   +2 more sources

Analysis of the structure and function of protein phosphatase 2A [PDF]

, 2004
One of the hallmarks of a living organism is the ability to respond to intra- or extracellular changes. These responses involve panoply of enzymes mediating signals through the cell and regulating distinct cellular functions.
Schmidt, Karsten
core   +1 more source