Cardiac cAMP-PKA Signaling Compartmentalization in Myocardial Infarction
Cells, 2021 Under physiological conditions, cAMP signaling plays a key role in the regulation of cardiac function. Activation of this intracellular signaling pathway mirrors cardiomyocyte adaptation to various extracellular stimuli.
Anne-Sophie Colombe, Guillaume Pidoux
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Crosstalk of noradrenergic Ca2+ and cAMP signaling in astrocytes of the murine olfactory bulb [PDF]
Cell Communication and SignalingCyclic adenosine monophosphate (cAMP) and Ca²⁺ are ubiquitous second messengers that regulate gene expression, metabolism, and synaptic plasticity. Here, we identified a complex interplay between Ca²⁺ and cAMP signaling pathways in mouse olfactory bulb ...
Jessica Sauer +7 more
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Early cAMP signaling orchestrates single-cell synchronicity throughout Dictyostelium development [PDF]
Communications BiologySynchronicity is observed in many biological systems, including development, as seen in vertebrate body axis formation, fly eye development, and development of the social amoeba D. discoideum.
Mariko Katoh-Kurasawa +6 more
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Membranes prime the RapGEF EPAC1 to transduce cAMP signaling [PDF]
Nature Communications, 2023 EPAC1, a cAMP-activated GEF for Rap GTPases, is a major transducer of cAMP signaling and a therapeutic target in cardiac diseases. The recent discovery that cAMP is compartmentalized in membrane-proximal nanodomains challenged the current model of EPAC1 ...
Candice Sartre +11 more
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Multiparametric imaging of spatio-temporal cAMP signaling, transmembrane potential, and intracellular calcium in the intact heart [PDF]
iScienceSummary: The spatiotemporal dynamics of intracellular second messengers and signaling molecules, including cyclic adenosine monophosphate (cAMP), have been studied extensively in isolated cardiomyocytes using Förster resonance energy transfer (FRET ...
I-Ju E. Lee +5 more
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Mechanistic insights from animal models of neurofibromatosis type 1 cognitive impairment
Disease Models & Mechanisms, 2022 Neurofibromatosis type 1 (NF1) is an autosomal-dominant neurogenetic disorder caused by mutations in the gene neurofibromin 1 (NF1). NF1 predisposes individuals to a variety of symptoms, including peripheral nerve tumors, brain tumors and cognitive ...
Andrew H. Miller, Mary C. Halloran
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Archives of Medical Science, 2021 Introduction Osteoporotic spinal fracture, characterized by high morbidity and mortality, has become a health burden for the aging population. Inactivation of the Wnt signaling has been proved to promote osteoporotic fractures.
Xiaohua Zuo +7 more
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Molecular Targets and Biological Functions of cAMP Signaling in Arabidopsis
Biomolecules, 2021 Cyclic AMP (cAMP) is a pivotal signaling molecule existing in almost all living organisms. However, the mechanism of cAMP signaling in plants remains very poorly understood.
Ruqiang Xu +6 more
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The cAMP-signaling cancers: Clinically-divergent disorders with a common central pathway
Frontiers in Endocrinology, 2022 The cAMP-signaling cancers, which are defined by functionally-significant somatic mutations in one or more elements of the cAMP signaling pathway, have an unexpectedly wide range of cell origins, clinical manifestations, and potential therapeutic options.
Graeme B. Bolger
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cAMP Signaling in Pathobiology of Alcohol Associated Liver Disease
Biomolecules, 2020 The importance of cyclic adenosine monophosphate (cAMP) in cellular responses to extracellular signals is well established. Many years after discovery, our understanding of the intricacy of cAMP signaling has improved dramatically.
Mohamed Elnagdy +3 more
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