Biophysical and aerodynamic properties of a peptide targeting the A-kinase anchoring function of PI3Kγ for pulmonary cAMP modulation [PDF]
Scientific ReportsCyclic AMP (cAMP) signaling specificity relies on precise spatial regulation mediated by A-kinase anchoring proteins (AKAPs), which localize protein kinase A (PKA) within defined microdomains.
Angela Della Sala +12 more
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Targeting PI3Kγ anchoring enhances CFTR membrane localization and modulator efficacy via PKD1 [PDF]
JCI InsightMutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes a cAMP-activated chloride channel, cause cystic fibrosis (CF), the most common life-threatening inherited disorder among White individuals.
Alessandra Murabito +12 more
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The role of A-kinase anchoring proteins in cardiovascular diseases and recent advances [PDF]
Frontiers in Cell and Developmental BiologyCardiovascular diseases are a major global health concern, leading to high morbidity, mortality, and disability rates. Scaffold proteins, particularly A-kinase anchoring proteins (AKAPs), play a crucial role in signal transduction within the ...
Xu Zhang +4 more
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Exploration of Novel Markers in Tan Sheep Spermatogenesis [PDF]
AnimalsIn livestock farming, the reproductive function and breeding performance of Tan sheep are crucial for enhancing farming efficiency. Despite advances in research on sheep germ cells, studies on the identification of markers for spermatogonia ...
Yuan Ma +5 more
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Protein Kinase A Regulates Platelet Phosphodiesterase 3A through an A-Kinase Anchoring Protein Dependent Manner [PDF]
CellsPlatelet activation is critical for haemostasis, but if unregulated can lead to pathological thrombosis. Endogenous platelet inhibitory mechanisms are mediated by prostacyclin (PGI2)-stimulated cAMP signalling, which is regulated by phosphodiesterase 3A (
Jawad S. Khalil +7 more
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AKAP8L enhances the stemness and chemoresistance of gastric cancer cells by stabilizing SCD1 mRNA
Cell Death and Disease, 2022 Gastric cancer (GC) remains the third leading cause of cancer-related deaths. Chemoresistance is the major determinant of GC treatment failure. To explore the molecular mechanisms of GC chemoresistance, mass spectrometry was performed to detect the genes
Ruihong Zhang +10 more
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Molecular Pain, 2023 Changes in sensory afferent activity contribute to the transition from acute to chronic pain. However, it is unlikely that a single sensory receptor is entirely responsible for persistent pain.
Yan Zhang, Nathaniel A Jeske
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Functional and Structural Mimicry of Cellular Protein Kinase A Anchoring Proteins by a Viral Oncoprotein. [PDF]
PLoS Pathogens, 2016 The oncoproteins of the small DNA tumor viruses interact with a plethora of cellular regulators to commandeer control of the infected cell. During infection, adenovirus E1A deregulates cAMP signalling and repurposes it for activation of viral gene ...
Cason R King +5 more
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An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells. [PDF]
PLoS ONE, 2018 Stimulation of renal collecting duct principal cells with antidiuretic hormone (arginine-vasopressin, AVP) results in inhibition of the small GTPase RhoA and the enrichment of the water channel aquaporin-2 (AQP2) in the plasma membrane.
Katharina Schrade +26 more
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Cells, 2020 Arginine-vasopressin (AVP) facilitates water reabsorption in renal collecting duct principal cells through regulation of the water channel aquaporin-2 (AQP2).
Alessandro Dema +16 more
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