Results 11 to 20 of about 6,190 (209)

Domain architecture of a Caenorhabditis elegans AKAP suggests a novel AKAP function [PDF]

FEBS Letters, 2000
A‐kinase anchoring proteins (AKAPs) are adapter proteins that are involved in directing cAMP‐dependent protein kinase and some other signaling enzymes to certain intracellular locations. In this study, we investigate the domain architecture of an AKAP from Caenorhabditis elegans (AKAPCE).
Herrgård, Sanna, Jambeck, Per, Taylor, Susan S., Subramaniam, Shankar   +3 more
openaire   +3 more sources

Disruptors of AKAP-Dependent Protein–Protein Interactions

, 2022
A-kinase anchoring proteins (AKAPs) are a family of multivalent scaffolding proteins. They engage in direct protein-protein interactions with protein kinases, kinase substrates and further signaling molecules. Each AKAP interacts with a specific set of protein interaction partners and such sets can vary between different cellular compartments and cells.
Ryan Walker-Gray, Tamara Pallien, Duncan C. Miller, Andreas Oder, Martin Neuenschwander, Jens Peter von Kries, Sebastian Diecke, Enno Klussmann   +7 more
openaire   +3 more sources

Development of peptidic disruptors for the inhibition of AKAP-PKA interactions and bioinformatics approach to identify new AKAPs

, 2008
Die Verankerung der PKA durch AKAP stellt einen entscheidenden Schritt im cAMP-Signalweg dar. In der vorliegenden Arbeit wurden Werkzeuge entwickelt, um die PKA Verankerung zu untersuchen: Peptide hoher Affinität zu RII- Untereinheiten der PKA, die von AKAP18d durch systematischen Aminosäureaustausch abgeleitet wurden.
Hundsrucker, Christian
openaire   +2 more sources

Function of Adenylyl Cyclase in Heart: the AKAP Connection [PDF]

Journal of Cardiovascular Development and Disease, 2018
Cyclic adenosine monophosphate (cAMP), synthesized by adenylyl cyclase (AC), is a universal second messenger that regulates various aspects of cardiac physiology from contraction rate to the initiation of cardioprotective stress response pathways.
Tanya A. Baldwin, Carmen W. Dessauer
doaj   +3 more sources

AKAP-4 as a biomarker for prostate cancer

, 2008
Objective. Prostate cancer (PC) is the second most common cancer in older men, after skin cancer, with 218,890 new cases estimated and 27,050 deaths expected in the United States for 2007. PC is difficult to diagnose because prostate specific antigen (PSA) screening method is associated with many false positives.
M. Chiriva Internati, N. Gagliano, M. Gioia, Y. Yu, E. Cobos   +4 more
core   +4 more sources

N3A motifs in RIβ mediate allosteric crosstalk between cAMP and ATP in PKA activation. [PDF]

Protein Sci
Abstract The RIβ subunit of cAMP‐dependent protein kinase (PKA) is highly expressed in the brain, yet it remains the least studied of the PKA regulatory subunits (R). As pathologic variants of its gene are increasingly implicated in neurodevelopmental disorders, neurodegeneration, and cancer, gaining more information about the structure/function of RIβ,
Wu J, Bruystens JGH, Sahoo P, Bubis J, Maillard RA, Taylor SS, Ilouz R.   +6 more
europepmc   +2 more sources

AKAP signaling complexes at the cytoskeleton [PDF]

Journal of Cell Science, 2001
ABSTRACT Targeting of protein kinases and phosphatases to the cytoskeleton enhances the regulation of signal transduction events. The assembly of cytoskeletal signaling complexes facilitates the relay of messages from membrane receptors to specific sites on the actin cytoskeleton. These signals influence fundamental cell properties, such
D, Diviani, J D, Scott
openaire   +2 more sources

Hedgehog and Gpr161: Regulating cAMP Signaling in the Primary Cilium

Cells, 2020
Compartmentalization of diverse types of signaling molecules contributes to the precise coordination of signal propagation. The primary cilium fulfills this function by acting as a spatiotemporally confined sensory signaling platform.
Philipp Tschaikner, Florian Enzler, Omar Torres-Quesada, Pia Aanstad, Eduard Stefan   +4 more
doaj   +1 more source

AKAP Phosphatase Complexes in the Heart [PDF]

Journal of Cardiovascular Pharmacology, 2011
Directed protein phosphorylation is indisputably critical for a multitude of cellular processes. A growing body of research demonstrates A kinase anchoring proteins (AKAPs) to mediate a significant number of phosphorylation events in the heart. By acting as molecular tethers for the regulatory subunit of protein kinase A, AKAPs focus kinase activity ...
John M, Redden, Kimberly L, Dodge-Kafka
openaire   +2 more sources

AKAP79 and the evolution of the AKAP model [PDF]

FEBS Letters, 2000
A molecular explanation for the specificity of the cAMP‐dependent protein kinase (PKA) can be provided by its compartmentalization through association with A‐kinase‐anchoring proteins (AKAPs). Structural and functional studies have led to the development of an anchoring model proposing that AKAPs contain a common PKA binding domain and a unique ...
Dodge, Kimberley, Scott, John D
openaire   +2 more sources