Results 21 to 30 of about 6,190 (209)

β-Amyloid disruption of LTP/LTD balance is mediated by AKAP150-anchored PKA and Calcineurin regulation of Ca2+-permeable AMPA receptors

Cell Reports, 2021
Summary: Regulated insertion and removal of postsynaptic AMPA glutamate receptors (AMPARs) mediates hippocampal long-term potentiation (LTP) and long-term depression (LTD) synaptic plasticity underlying learning and memory.
Jennifer L. Sanderson, Ronald K. Freund, Jessica A. Gorski, Mark L. Dell’Acqua   +3 more
doaj   +1 more source

Phosphoproteomic Analysis Reveals Downstream PKA Effectors of AKAP Cypher/ZASP in the Pathogenesis of Dilated Cardiomyopathy

Frontiers in Cardiovascular Medicine, 2021
Background: Dilated cardiomyopathy (DCM) is a major cause of heart failure worldwide. The Z-line protein Cypher/Z-band alternatively spliced PDZ-motif protein (ZASP) is closely associated with DCM, both clinically and in animal models.
Jialan Lv, Zhicheng Pan, Jian Chen, Rui Xu, Dongfei Wang, Jiaqi Huang, Yang Dong, Jing Jiang, Xiang Yin, Hongqiang Cheng, Xiaogang Guo   +10 more
doaj   +1 more source

A-kinase anchoring in dendritic cells is required for antigen presentation. [PDF]

PLoS ONE, 2009
BACKGROUND: Dendritic cells (DC) are the most potent antigen presenting cells (APC) of the immune system. Prostaglandin E(2), cyclic AMP, and protein kinase A (PKA) have all been shown to regulate DC maturation and activity.
Robynn V Schillace, Casey L Miller, Neal Pisenti, Jeff E Grotzke, Gwendolyn M Swarbrick, David M Lewinsohn, Daniel W Carr   +6 more
doaj   +1 more source

Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs)

BMC Cancer, 2018
Background Tumor heterogeneity in breast cancer tumors is today widely recognized. Most of the available knowledge in genetic variation however, relates to the primary tumor while metastatic lesions are much less studied.
Una Kjällquist, Rikard Erlandsson, Nicholas P. Tobin, Amjad Alkodsi, Ikram Ullah, Gustav Stålhammar, Eva Karlsson, Thomas Hatschek, Johan Hartman, Sten Linnarsson, Jonas Bergh   +10 more
doaj   +1 more source

Regulation of AKAP-Membrane Interactions by Calcium [PDF]

Journal of Biological Chemistry, 2006
The AKAP gravin is a scaffold for protein kinases, phosphatases, and adaptor molecules obligate for resensitization and recycling of beta2-adrenergic receptors. Gravin binds to the receptor through well characterized protein-protein interactions. These interactions are facilitated approximately 1000-fold when gravin is anchored to the cytoplasmic ...
Jiangchuan, Tao, Elena, Shumay, Stuart, McLaughlin, Hsien-yu, Wang, Craig C, Malbon   +4 more
openaire   +2 more sources

Aldosterone Impairs Mitochondrial Function in Human Cardiac Fibroblasts via A-Kinase Anchor Protein 12

Scientific Reports, 2018
Aldosterone (Aldo) contributes to mitochondrial dysfunction and cardiac oxidative stress. Using a proteomic approach, A-kinase anchor protein (AKAP)-12 has been identified as a down-regulated protein by Aldo in human cardiac fibroblasts.
Jaime Ibarrola, Rafael Sadaba, Ernesto Martinez-Martinez, Amaia Garcia-Peña, Vanessa Arrieta, Virginia Alvarez, Amaya Fernández-Celis, Alicia Gainza, Victoria Cachofeiro, Enrique Santamaria, Joaquin Fernandez-Irigoyen, Frederic Jaisser, Natalia Lopez-Andres   +12 more
doaj   +1 more source

Exploring AKAPs in visual signaling. [PDF]

Front Mol Neurosci
The complex nature of the retina demands well-organized signaling to uphold signal accuracy and avoid interference, a critical aspect in handling a variety of visual stimuli. A-kinase anchoring proteins (AKAPs), known for binding protein kinase A (PKA), contribute to the specificity and efficiency of retinal signaling.
Tomczak J, Mackiewicz J, Lisek M, Kaluza A, Boczek T.   +4 more
europepmc   +4 more sources

Protein kinase A activity and anchoring are required for ovarian cancer cell migration and invasion. [PDF]

PLoS ONE, 2011
Epithelial ovarian cancer (EOC) is the deadliest of the gynecological malignancies, due in part to its clinically occult metastasis. Therefore, understanding the mechanisms governing EOC dissemination and invasion may provide new targets for ...
Andrew J McKenzie, Shirley L Campbell, Alan K Howe   +2 more
doaj   +1 more source

Disruption of AKAP-PKA Interaction Induces Hypercontractility With Concomitant Increase in Proliferation Markers in Human Airway Smooth Muscle

Frontiers in Cell and Developmental Biology, 2020
With the ability to switch between proliferative and contractile phenotype, airway smooth muscle (ASM) cells can contribute to the progression of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), in which airway obstruction
Hoeke A. Baarsma, Hoeke A. Baarsma, Bing Han, Bing Han, Wilfred J. Poppinga, Wilfred J. Poppinga, Saskia Driessen, Carolina R. S. Elzinga, Andrew J. Halayko, Herman Meurs, Herman Meurs, Harm Maarsingh, Martina Schmidt, Martina Schmidt   +13 more
doaj   +1 more source

Hidden Multivalency in Phosphatase Recruitment by a Disordered AKAP Scaffold [PDF]

Journal of Molecular Biology, 2021
Abstract Disordered scaffold proteins provide multivalent landing pads that, via a series of embedded Short Linear Motifs (SLiMs), bring together the components of a complex to orchestrate precise spatial and temporal regulation of cellular processes.
Matthew Watson, Teresa B. Almeida, Arundhati Ray, Christina Hanack, Rory Elston, Joan Btesh, Peter A. McNaughton, Katherine Stott   +7 more
openaire   +2 more sources