Results 31 to 40 of about 6,190 (209)

A Model and Analysis of the AKAP Scaffold

Electronic Notes in Theoretical Computer Science, 2010
AbstractWe study the biochemical processes involved in scaffold-mediated crosstalk between the cAMP and the Raf-1/MEK/ERK pathways. We model the system by a continuous time Markov chain with levels and analyse properties using Continuous Stochastic Logic and the symbolic probabilistic model checker PRISM.
Oana Andrei, Muffy Calder
openaire   +2 more sources

Domain architecture of a Caenorhabditis elegans AKAP suggests a novel AKAP function [PDF]

, 2020
A-kinase anchoring proteins (AKAPs) are adapter proteins that are involved in directing cAMP-dependent protein kinase and some other signaling enzymes to certain intracellular locations.

core  

PKA, PKC, and AKAP localization in and around the neuromuscular junction

BMC Neuroscience, 2001
Background One mechanism that directs the action of the second messengers, cAMP and diacylglycerol, is the compartmentalization of protein kinase A (PKA) and protein kinase C (PKC). A-kinase anchoring proteins (AKAPs) can recruit both enzymes to specific
Newton Alexandra, Smith Donelson, Violin Jonathan D, Barraclough David M, Deerinck Thomas J, Martone Maryann, Yao Virginia J, Humphries Kenneth, Huang Lily, Wang Lin, Perkins Guy A, Scott John D, Taylor Susan S, Ellisman Mark H   +13 more
doaj   +1 more source

Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons. [PDF]

PLoS ONE, 2011
Neuronal high-voltage-activated (HVA) Ca(2+) channels are rapidly inactivated by a mechanism that is termed Ca(2+)-dependent inactivation (CDI). In this study we have shown that β-adrenergic receptor (βAR) stimulation inhibits CDI in rat thalamocortical (
Vladan Rankovic, Peter Landgraf, Tatyana Kanyshkova, Petra Ehling, Sven G Meuth, Michael R Kreutz, Thomas Budde, Thomas Munsch   +7 more
doaj   +1 more source

Selective Disruption of the AKAP Signaling Complexes [PDF]

, 2015
Synthesis of the second messenger cAMP activates a variety of signaling pathways critical for all facets of intracellular regulation. Protein kinase A (PKA) is the major cAMP-responsive effector. Where and when this enzyme is activated has profound implications on the cellular role of PKA.
Eileen J, Kennedy, John D, Scott
openaire   +2 more sources

AKAP signaling complexes: getting to the heart of the matter [PDF]

Trends in Molecular Medicine, 2006
Subcellular compartmentalization of protein kinases and phosphatases through their interaction with A-kinase anchoring proteins (AKAPs) provides a mechanism to control signal transduction events at specific sites within the cell. Recent findings suggest that these anchoring proteins dynamically assemble different cAMP effectors to control the cellular ...
George, McConnachie, Lorene K, Langeberg, John D, Scott   +2 more
openaire   +2 more sources

Tracking human multiple myeloma xenografts in NOD-Rag-1/IL-2 receptor gamma chain-null mice with the novel biomarker AKAP-4

BMC Cancer, 2011
Background Multiple myeloma (MM) is a fatal malignancy ranking second in prevalence among hematological tumors. Continuous efforts are being made to develop innovative and more effective treatments.
Jenkins Marjorie R, Yu Yuefei, Mirandola Leonardo, Chiaramonte Raffaella, Cobos Everardo, John Constance M, Chiriva-Internati Maurizio   +6 more
doaj   +1 more source

Aplikasi Mobile Informasi Jadwal Transit Bus AKAP dan AKDP

Jurnal Informatika dan Multimedia, 2023
Transportasi umum merupakan salah satu kebutuhan masyarakat yang sangat diminati khususnya oleh masyarakat kota dalam kehidupan sehari-hari. Bus Antar Kota Antar Propinsi (AKAP) dan Antar Kota Dalam Propinsi (AKDP) merupakan salah satu jenis ...
Benni Agung Nugroho, Fery Sofian Efendi
doaj   +1 more source

AKAPs: The architectural underpinnings of local cAMP signaling [PDF]

Journal of Molecular and Cellular Cardiology, 2012
The cAMP-dependent protein kinase A (PKA) is targeted to specific compartments in the cardiac myocyte by A-kinase anchoring proteins (AKAPs), a diverse set of scaffold proteins that have been implicated in the regulation of excitation-contraction coupling and cardiac remodeling.
Michael D, Kritzer, Jinliang, Li, Kimberly, Dodge-Kafka, Michael S, Kapiloff   +3 more
openaire   +2 more sources

Beyond Simple Mimicry: Next‐Generation Geometric Architectures and Future Paradigms in Small‐Molecule and Macrocyclic Peptidomimetics

Angewandte Chemie, Volume 138, Issue 40, 28 September 2026.
Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee, Sumin Son, Jeong Yeon Yoo, Ji Hyae Lee, Meehyun Chun, Seung Bum Park   +5 more
wiley   +2 more sources