Results 41 to 50 of about 6,190 (209)
A-Kinase Anchoring Protein-Lbc: A Molecular Scaffold Involved in Cardiac Protection
Journal of Cardiovascular Development and Disease, 2018 Heart failure is a lethal disease that can develop after myocardial infarction, hypertension, or anticancer therapy. In the damaged heart, loss of function is mainly due to cardiomyocyte death and associated cardiac remodeling and fibrosis.
Dario Diviani, Halima Osman, Erica Reggi
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Scientific Reports, 2017 Mechanical pain serves as a base clinical symptom for many of the world’s most debilitating syndromes. Ion channels expressed by peripheral sensory neurons largely contribute to mechanical hypersensitivity.
Allison Doyle Brackley +7 more
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Cells, 2020 Epithelial-to-mesenchymal transition (EMT) plays a role in chronic obstructive pulmonary diseases (COPD). Cyclic adenosine monophosphate (cAMP) can inhibit transforming growth factor-β1 (TGF-β1) mediated EMT. Although compartmentalization via A-
Haoxiao Zuo +9 more
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The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex. [PDF]
, 2014 The RhoGEF (Rho GTPase guanine-nucleotide-exchange factor) domain of AKAP-Lbc (A-kinase-anchoring protein-Lbc, also known as AKAP13) catalyses nucleotide exchange on RhoA and is involved in the development of cardiac hypertrophy.
Knapp, Stefan +10 more
core +1 more source
PKA holoenzyme is functionally coupled to CFTR by AKAPs [PDF]
American Journal of Physiology-Cell Physiology, 2000 Cystic fibrosis transmembrane regulator (CFTR) is reported to be preferentially regulated by membrane-bound protein kinase A (PKAII). We tested for close physical and functional association of PKA with CFTR in inside-out membrane patches excised from Calu-3 cells.
Huang, P. +4 more
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AKAP-Scaffolding Proteins and Regulation of Cardiac Physiology [PDF]
Physiology, 2009 A kinase anchoring proteins (AKAPs) compose a growing list of diverse but functionally related proteins defined by their ability to bind to the regulatory subunit of protein kinase A. AKAPs perform an integral role in the spatiotemporal modulation of a multitude of cellular signaling pathways.
MAUBAN JRH +4 more
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Role of a-kinase anchoring proteins (AKAPs) in reproduction [PDF]
Frontiers in Bioscience, 2011 Rapid spatio-temporal organized intracellular signaling is a pivotal mechanism for regulation of functions in many cells, in particular in the female and male gametes, in which functional regulation through rapid increases in protein content is not possible since the mechanisms of transcription/translation are somehow frozen due to meiosis block or DNA
LUCONI, MICHAELA +3 more
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Frontiers in Endocrinology, 2022 X-linked hypophosphatemia (XLH), an inheritable form of rickets is caused due to mutation in Phex gene. Several factors are linked to the disease’s aetiology, including non-coding RNA molecules (miRNAs), which are key post-transcriptional regulators of ...
Alok Tripathi +13 more
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Jurnal Empati, 2017 Penelitian ini bertujuan untuk mengetahui ada atau tidaknya hubungan antara kepuasan kerja dengan stres kerja pada supir PO AGRA MAS (Divisi AKAP) tujuan Wonogiri - Jakarta.
Ready Nurdian Syah, Endang Sri Indrawati
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Andrology, EarlyView.ABSTRACT Background Sperm cryopreservation causes cryodamage, but the roles of posttranslational modifications (PTMs) and stress granules (SGs) in this process remain unclear. Objectives To investigate the molecular mechanism of cryodamage via the TRIM21–AKAP3 axis, PTMs, and SGs.
Yan Wang +9 more
wiley +1 more source