Results 61 to 70 of about 6,190 (209)

PKA compartmentalization via AKAP220 and AKAP12 contributes to endothelial barrier regulation. [PDF]

PLoS ONE, 2014
cAMP-mediated PKA signaling is the main known pathway involved in maintenance of the endothelial barrier. Tight regulation of PKA function can be achieved by discrete compartmentalization of the enzyme via physical interaction with A-kinase anchoring ...
Mariya Y Radeva, Daniela Kugelmann, Volker Spindler, Jens Waschke   +3 more
doaj   +1 more source

AKAP Signaling Islands: Venues for Precision Pharmacology

Trends in Pharmacological Sciences, 2020
Regulatory enzymes often have different roles in distinct subcellular compartments. Yet, most drugs indiscriminately saturate the cell. Thus, subcellular drug-delivery holds promise as a means to reduce off-target pharmacological effects. A-kinase anchoring proteins (AKAPs) sequester combinations of signaling enzymes within subcellular microdomains ...
Mitchell H, Omar, John D, Scott
openaire   +3 more sources

Roles of A-Kinase Anchoring Proteins and Phosphodiesterases in the Cardiovascular System

Journal of Cardiovascular Development and Disease, 2018
A-kinase anchoring proteins (AKAPs) and cyclic nucleotide phosphodiesterases (PDEs) are essential enzymes in the cyclic adenosine 3’-5’ monophosphate (cAMP) signaling cascade.
Maria Ercu, Enno Klussmann
doaj   +1 more source

Direct AKAP-mediated protein-protein interactions as potential drug targets

, 2008
A-kinase-anchoring proteins (AKAPs) are a diverse family of about 50 scaffolding proteins. They are defined by the presence of a structurally conserved protein kinase A (PKA)-binding domain.
Hundsrucker, Christian, E. Klussmann, C. Hundsrucker, Hundsrucker, C., Klussmann, E.   +4 more
core   +1 more source

The long way to innovation adoption: insights from precision agriculture

Agricultural and Food Economics, 2022
The adoption of innovations may boost the transition to sustainable agricultural models. Among these innovations, precision farming offers a fundamental contribution to sustainable soil management and the improvement in product quality.
Margherita Masi, Marcello De Rosa, Yari Vecchio, Luca Bartoli, Felice Adinolfi   +4 more
doaj   +1 more source

CaV1.2 dynamics in native male arterial myocytes

The Journal of Physiology, Volume 604, Issue 15, Page 6302-6323, 1 August 2026.
Abstract figure legend Proposed model of microtubule‐dependent CaV1.2 reorganization in vascular disease. Schematic illustration of microtubule‐mediated delivery and stabilization of CaV1.2 channels into enlarged plasma membrane clusters in response to Ang II or hyperglycaemia, promoting cooperative gating and enhanced Ca2+ influx. Abstract L‐type CaV1.
Miguel Martin‐Aragon Baudel, Hannah Voorhees, Arsalan U. Syed, Maryann K. Ferrara, Mary Horne, Johannes W. Hell, Luis F. Santana, Rose E. Dixon, Madeline Nieves‐Cintron, Manuel F. Navedo   +9 more
wiley   +1 more source

Preparedness and Post‐Pandemic Return to Nepal and the Philippines

International Migration, Volume 64, Issue 4, July 2026.
ABSTRACT The COVID‐19 pandemic halted international mobility and greatly affected temporary migrant workers working abroad. This article looks at the pandemic‐induced return of migrant workers from two major Asian labour sending states: Nepal and the Philippines.
Richa Shivakoti
wiley   +1 more source

Therapeutic strategies for anchored kinases and phosphatases: exploiting short linear motifs and intrinsic disorder

Frontiers in Pharmacology, 2015
Phosphorylation events that occur in response to the second messenger cAMP are controlled spatially and temporally by protein kinase A (PKA) interacting with A-kinase anchoring proteins (AKAPs).
Patrick J Nygren, Patrick J Nygren, John D. Scott, John D. Scott   +3 more
doaj   +1 more source

A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Protein kinases (PKs) are enzymes that catalyze phosphorylation of protein substrates involved in a wide variety of biological signalling pathways. This review describes the different families and mechanisms of action and regulation of protein kinases, together with the different classes of fluorescent biosensors that have been engineered and ...
Timothe Abbura, May C. Morris
wiley   +1 more source

Charakterisierung kleiner Moleküle zur Hemmung von AKAP-PKA-Interaktionen

, 2009
A-kinase anchoring proteins (AKAP) tether the cAMP-dependent protein kinase (PKA) to subcellular structures in proximity to its substrates, providing the basis for compartmentalised cAMP signalling.
Christian, Frank
core   +1 more source