Results 71 to 80 of about 6,190 (209)
The Rho-Gef Akap-Brx Is A Co-Activator Of Progesterone Receptor B In Uterine Leiomyoma Cells [PDF]
, 2013 Background--Uterine leiomyomas, or fibroids, are prevalent tumors that are dependent on sex steroids for growth. Clinically, progesterone promotes fibroid growth and anti-progestins cause a durable reduction in fibroid size, yet the mechanisms underlying
Jorge, Soledad
core +1 more source
Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins
Frontiers in Pharmacology, 2015 Cyclic AMP is a ubiquitous intracellular second messenger involved in the regulation of a wide variety of cellular processes, a majority of which act through the cAMP - protein kinase A (PKA) signalling pathway and involve PKA phosphorylation of specific
Ana Isabel C. Calejo, Kjetil eTaskén
doaj +1 more source
The Stapled AKAP Disruptor Peptide STAD-2 Displays Antimalarial Activity through a PKA-Independent Mechanism. [PDF]
PLoS ONE, 2015 Drug resistance poses a significant threat to ongoing malaria control efforts. Coupled with lack of a malaria vaccine, there is an urgent need for the development of new antimalarials with novel mechanisms of action and low susceptibility to parasite ...
Briana R Flaherty +6 more
doaj +1 more source
Deciphering mRNA Translation During Sperm Capacitation: A New Frontier in Fertility Research
Molecular Reproduction and Development, Volume 93, Issue 2, February 2026.ABSTRACT Male infertility accounts for approximately 50% of infertility cases, with nearly 30% remaining unexplained after standard evaluations. This highlights the need for a better understanding of sperm function to advance diagnostic and therapeutic strategies. Sperm were long considered translationally quiescent; however, emerging evidence suggests
Saurabh Tiwari +2 more
wiley +1 more source
Networking with AKAPs: Context-dependent Regulation of Anchored Enzymes [PDF]
Molecular Interventions, 2010 A-Kinase Anchoring Proteins (AKAPs) orchestrate and synchronize cellular events by tethering the cAMP-dependent protein kinase (PKA) and other signaling enzymes to organelles and membranes. The control of kinases and phosphatases that are held in proximity to activators, effectors, and substrates favors the rapid dissemination of information from one ...
Emily J, Welch +2 more
openaire +2 more sources
Targeted disruption of PKC from AKAP signaling complexes
RSC Chemical Biology, 2021 We report the development of AKAP derived, conformationally constrained peptides designed to probe AKAP-localized PKC. The lead peptides, CSTAD5 and CSTAD6 permeate cells, bind PKC, disrupt its scaffolding by AKAPs to inhibit its scaffolded activity.
Ameya J. Limaye +2 more
openaire +3 more sources
Decreased AKAP4/PKA signaling pathway in high DFI sperm affects sperm capacitation
Asian Journal of AndrologyThe sperm DNA fragmentation index (DFI) is a metric used to assess DNA fragmentation within sperm. During in vitro fertilization-embryo transfer (IVF-ET), high sperm DFI can lead to a low fertilization rate, poor embryo development, early miscarriage ...
Kun Zhang +6 more
doaj +1 more source
PEMAKAIAN REGISTER BAHASA KRU BUS AKAP DI TERMINAL TIRTONADI SURAKARTA (Kajian Sosiolinguistik)
Dialektika: Jurnal Bahasa, Sastra, dan Pendidikan Bahasa dan Sastra Indonesia, 2019 : The research entitled “Pattern Register Language Bus Crews Inter City Inter Provincial (AKAP) at Terminal Tirtonadi Surakarta” aims to describe the form of the registers of the inter-provincial city bus crew in the Tirtonadi Terminal of Surakarta ...
Elen Inderasari, wahyu oktavia
doaj +1 more source
Frontiers in Physiology, 2020 Our understanding of the general principles of the polymodal regulation of transient receptor potential (TRP) ion channels has grown impressively in recent years as a result of intense efforts in protein structure determination by cryo-electron ...
Lucie Zimova +8 more
doaj +1 more source
A Novel A‐Kinase‐Anchoring Protein 9 Variant in Premature Coronary Artery Disease: A Case Series
Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.AKAP9 Q2136E mutation disrupts AKAP9–PRKAR2A interaction and may contribute to early‐onset CAD. ABSTRACT Background Familial premature coronary artery disease (CAD) is often associated with genetic variants. This study investigated potential causal variants in a Chinese pedigree with premature CAD. Methods In total, nine family members were included in
Yuemiao Jiao +7 more
wiley +1 more source