Results 91 to 100 of about 6,190 (209)

HUBUNGAN ANTARA PERSEPSI TERHADAP RISIKO DENGAN AGGRESSIVE DRIVING PADA SOPIR BUS AKAP [PDF]

, 2020
Penelitian ini bertujuan untuk mengetahui hubungan antara persepsi terhadap risiko dengan aggressive driving pada sopir bus AKAP. Penelitian ini menggunakan metode kuantitatif.Subjek penelitian ini adalah sopir bus AKAP PO Pahala Kencana yang berjumlah ...
Kurniawan, Fathoni Dwi, Kuncoro, Joko
core   +1 more source

A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains

The FEBS Journal, Volume 292, Issue 17, Page 4477-4486, September 2025.
Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley   +1 more source

Allosteric modulation of protein kinase A in individuals affected by NLPD‐PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed

The FEBS Journal, Volume 292, Issue 18, Page 4808-4832, September 2025.
In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman, Valeria Pane, Rania Safadi‐Safa, Meir Solomon, Varda Lev‐Ram, Mohammad Aboraya, Anwar Dakwar, Daniela Bertinetti, Andrew Hoy, Merel O. Mol, John van Swieten, Rodrigo Maillard, Friedrich W. Herberg, Ronit Ilouz   +13 more
wiley   +1 more source

Protein kinase A: a quirky prototype

The FEBS Journal, Volume 292, Issue 18, Page 4800-4803, September 2025.
Protein kinase A (PKA) has served as a prototype for establishing kinase fundamentals, including sequence, structure and catalytic mechanism. However, PKA is quirky in some respects. Its regulatory elements are expressed separately, including type I (RI) regulatory subunits that contain unusual disulphide‐linked dimerization and docking domains ...
Matthew G. Gold
wiley   +1 more source

LTP but not seizure is associated with up-regulation of AKAP-150

, 2003
We have used differential display to profile and compare the mRNAs expressed in the hippocampus of freely moving animals after the induction of long-term potentiation (LTP) at the perforant path–dentate gyrus synapse with control rats receiving low ...
Génin, S, Errington, M, Hunt, S.P., Truchet, B, Laroche, S., Bliss, V, Richter-Levin, G., Stean, T., Sanger, G, Errington, ML, French, P, Mallet, J, Mallet, J., Truchet, T, Bliss, TVP, Doyère, V., Maroun, M., Wills, T, O'Connor, V, Sanger, G., French, P., Genin, A, Mallet, Jacques, Davis, S., Bliss, T.V.P., Webber, M, Hunt, S, Laroche, Serge, Richter-Levin, G, Doyère, V, Webber, M., Errington, M.L., O'Connor, V., French, Pim; id_orcid, Maroun, M, Davis, S, Stean, T, Truchet, B., Stean, S, Génin, A., Laroche, S, Wills, T., Sanger, S, Hunt, SP, O' Connor, V   +44 more
core   +1 more source

Analisis Hubungan Beban Kerja Mental dengan Situation Awareness Sopir Bus AKAP PT. Angkasa Trans Jaya.

, 2023
Sopir bus AKAP cenderung memiliki beban kerja mental yang tinggi , hal ini dapat disebabkan karena durasi jam kerja yang panjang dan waktu istirahat yang tidak menentu, situasi dan kondisi lalu lintas juga dapat mempengaruhi seperti kondisi kemacetan ...
Astuteryanti Tri Lustyana, ST., MT., Triasari, Qisthina   +1 more
core  

AKAP95: A multifunctional scaffold kinase anchoring protein, role in pathophysiology and perspectives for its therapeutic use

Pharmacological Research
Regulatory enzymes fulfill critical roles within specific subcellular compartments. Scaffolding proteins orchestrate enzyme activity and signal transduction by confining these processes to distinct spatial locations, thereby forming functional ...
Xu Wang, Jinlian He, Gangyuan Ma, Feng Zhou, Liqing Chen, Liang Liu   +5 more
doaj   +1 more source

Isoform-Selective Disruption of AKAP-Localized PKA Using Hydrocarbon Stapled Peptides

, 2015
A-kinase anchoring proteins (AKAPs) play an important role in the spatial and temporal regulation of protein kinase A (PKA) by scaffolding critical intracellular signaling complexes. Here we report the design of conformationally constrained peptides that
Tienhuei G. Ho (1312338), Avinash Sukhu (1312350), Yuxiao Wang (235398), Matthias Neddermann (1312347), Eileen J. Kennedy (374107), Raybun C. Spelts (1312341), Jin Zhang (53297), Daniela Bertinetti (226973), Eugen Franz (689040), Gary C. H. Mo (1312344), Friedrich W. Herberg (171465), Lewis P. Schendowich (1312335)   +11 more
core   +1 more source

Regulation of the AKAP-LBC signaling complex : molecular characterization and functional implications

, 2007
RÉSUMÉ Les protéines d'ancrage de la protéine kinase A (AKAPs) constituent une grande famille de protéines qui ciblent la protéine kinase A (PKA) à proximité de ses substrats physiologiques pour assurer leur régulation.
Baisamy, L.
core   +1 more source

Somatosensory Scaffolding Structures

Frontiers in Molecular Neuroscience, 2012
Dynamic changes in somatosensory perception occur as a result of multiple signaling events. In many instances, over-activation of sensory receptors results in the desensitization and subsequent increased threshold for activation of receptors.
Nathaniel Aaron Jeske
doaj   +1 more source