Results 101 to 110 of about 6,190 (209)
Proteomic Analyses of PKA and AKAP Signaling in Cocaine Addiction [PDF]
Neuropsychopharmacology, 2012 The development and application of proteomics techniques allows for ab initio identification of changes in protein expression and modifications which drive cellular processes. In the case of behavioral neuroscience, these techniques may be applied toward identification of candidate proteins and cellular pathways within specific nuclei that are affected
openaire +2 more sources
Structure of D-AKAP2:PKA RI Complex: Insights into AKAP Specificity and Selectivity [PDF]
, 2010 SummaryA-kinase anchoring proteins (AKAPs) regulate cyclic AMP-dependent protein kinase (PKA) signaling in space and time. Dual-specific AKAP 2 (D-AKAP2) binds to the dimerization/docking (D/D) domain of both RI and RII regulatory subunits of PKA with ...
Kinderman, Francis S. +6 more
core +1 more source
Erythropoietin signaling regulates heme biosynthesis
eLife, 2017 Heme is required for survival of all cells, and in most eukaryotes, is produced through a series of eight enzymatic reactions. Although heme production is critical for many cellular processes, how it is coupled to cellular differentiation is unknown ...
Jacky Chung +21 more
doaj +1 more source
Characterization of small molecule inhibitors of the AKAP-Lbc-induced RhoA activation
, 2012 Das A-kinase Ankerprotein AKAP-Lbc verankert die Proteinkinase A (PKA) und fungiert als Guaninnukleotidaustauschfaktor (GEF) für die kleine GTPase RhoA.
Tröger, Jessica
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Jurnal Sosiologi Andalas: Market and terminal are two places that can both be described as something crowded, noisy, complicated, and prone to crime. However, behind this general condition, it turns out that markets and terminals are inseparable symbiosis in the economy of ...
Ardi Abbas, Rinaldi Eka Putra
doaj +1 more source
The genetically encoded tool set for investigating cAMP: more than the sum of its parts
Frontiers in Pharmacology, 2015 Intracellular fluctuations of the second messenger cyclic AMP (cAMP) are regulated with spatial and temporal precision. This regulation is supported by the sophisticated arrangement of cyclases, phosphodiesterases, anchoring proteins and receptors for ...
Neha ePatel, Matthew G Gold
doaj +1 more source
AKAP Signaling in Reinstated Cocaine Seeking Revealed by iTRAQ Proteomic Analysis
, 2011 To identify candidate proteins in the nucleus accumbens (NAc) as potential pharmacotherapeutic targets for treating cocaine addition, an 8-plex iTRAQ (isobaric tag for relative and absolute quantitation) proteomic screen was performed using NAc tissue ...
Thomas E. Dunn +8 more
core +1 more source
, 2012 Zusammenfassung: AKAP-Lbc zaehlt zur Familie der A-Kinase-Ankerproteine (AKAPs), deren Hauptaufgabe in der Verankerung der cyclo Adenosinmonophosphat (cAMP) abhaengigen Proteinkinase A (PKA) an spezifische Zellkompartimente besteht.
Wallner, Eva-Sophie
core +2 more sources
, 2012 Kecelakaan lalu lintas merupakan masalah yang umum terjadi dalam penyelenggaraan sistem transportasi di banyak negara. Pada negara-negara berkembang, kecelakaan lalu lintas yang melibatkan bus AKAP ini cenderung mengalami peningkatan , dengan ...
Nugroho, RLukitoAdi
core
Jurnal Ilmiah KesehatanBackground: Low back pain disease varies greatly every year with a figure of 15-45%. According to the WHO, 33% of the population in developing countries experience persistent pain.
Wiratama Ibnu Parnonto +2 more
doaj +1 more source