Results 81 to 90 of about 6,190 (209)
Screening for small molecule disruptors of AKAP-PKA interactions
, 2015 Protein-protein interactions (PPIs) are highly specific and diverse. Their selective inhibition with peptides, peptidomimetics, or small molecules allows determination of functions of individual PPIs.
João Miguel Parente Fernandes +11 more
core +1 more source
Cell Reports, 2018 Summary: Ca2+-permeable AMPA-type glutamate receptors (CP-AMPARs) containing GluA1 but lacking GluA2 subunits contribute to multiple forms of synaptic plasticity, including long-term potentiation (LTP), but mechanisms regulating CP-AMPARs are poorly ...
Alicia M. Purkey +6 more
doaj +1 more source
Neural Plasticity, Volume 2026, Issue 1, 2026.Synaptic plasticity is a fundamental property of the nervous system that underpins learning, memory, and adaptive behavior across the lifespan. Disruption of plasticity mechanisms is increasingly recognized as a unifying feature of age‐related neurodegenerative and neuropsychiatric disorders.
Shaik Basha +7 more
wiley +1 more source
AKAPs integrate genetic findings for autism spectrum disorders [PDF]
Translational Psychiatry, 2013 Autism spectrum disorders (ASDs) are highly heritable, and six genome-wide association studies (GWASs) of ASDs have been published to date. In this study, we have integrated the findings from these GWASs with other genetic data to identify enriched genetic networks that are associated with ASDs.
Poelmans, G.J.V. +7 more
openaire +4 more sources
Sperm protein 17 is expressed in the sperm fibrous sheath
Journal of Translational Medicine, 2009 Background Sperm protein 17 (Sp17) is a highly conserved mammalian protein characterized in rabbit, mouse, monkey, baboon, macaque, human testis and spermatozoa. mRNA encoding Sp17 has been detected in a range of murine and human somatic tissues.
Albani Elena +11 more
doaj +1 more source
Conserved Functions of LARP1 Proteins in Eukaryotes
WIREs RNA, Volume 16, Issue 6, November/December 2025.LARP1 proteins are evolutionary conserved, and their function is influenced by both independent and coordinated roles of the La Motif and DM15 region, with a net effect on mRNA translation and stability. ABSTRACT La and La‐related proteins (LARPs) are conserved RNA‐binding proteins that share a characteristic La motif (LaM) and have important functions
Farnaz Mansouri‐Noori +1 more
wiley +1 more source
MedComm, Volume 6, Issue 10, October 2025.This review comprehensively examines the regulatory mechanisms and physiological roles of guanine nucleotide exchange factors (GEFs) and their small GTPase substrates, highlighting their significance in cellular processes and disease pathogenesis.
Zexing Lin +15 more
wiley +1 more source
Mitochondrial Homeostasis and Signaling in Parkinson’s Disease
Frontiers in Aging Neuroscience, 2020 The loss of dopaminergic (DA) neurons in the substantia nigra leads to a progressive, long-term decline of movement and other non-motor deficits. The symptoms of Parkinson’s disease (PD) often appear later in the course of the disease, when most of the ...
Antonella Scorziello +5 more
doaj +1 more source
Neurobeachin (NBEA) is a novel gene associated with GLP‐1 receptor agonist associated weight loss
Diabetes, Obesity and Metabolism, Volume 27, Issue 10, Page 5632-5642, October 2025.Abstract Aims Nearly 42% of adults in the United States have obesity, a significant risk factor for many cardiometabolic diseases and cancers. Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) are promising interventions for weight loss, but their efficacy varies significantly across individuals.
Arshiya Mariam‐Smith +6 more
wiley +1 more source
AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway.
, 2008 Elevated catecholamines in the heart evoke transcriptional activation of the Myocyte Enhancer Factor (MEF) pathway to induce a cellular response known as pathological myocardial hypertrophy.
Pedroja, B.S. +10 more
core +1 more source