Roles of A-Kinase Anchoring Proteins and Phosphodiesterases in the Cardiovascular System [PDF]
Journal of Cardiovascular Development and Disease, 2018 A-kinase anchoring proteins (AKAPs) and cyclic nucleotide phosphodiesterases (PDEs) are essential enzymes in the cyclic adenosine 3’-5’ monophosphate (cAMP) signaling cascade.
Maria Ercu, Enno Klussmann
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Polymorphisms/Mutations in A-Kinase Anchoring Proteins (AKAPs): Role in the Cardiovascular System [PDF]
Journal of Cardiovascular Development and Disease, 2018 A-kinase anchoring proteins (AKAPs) belong to a family of scaffolding proteins that bind to protein kinase A (PKA) by definition and a variety of crucial proteins, including kinases, phosphatases, and phosphodiesterases.
Santosh V. Suryavanshi +2 more
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Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins. [PDF]
Proc Natl Acad Sci U S A, 2018 Significance Dissemination of chemical information throughout the cell is a fundamental biological process with clinical relevance. Pathological changes in local signaling enzyme activity are linked to diseases, including schizophrenia, Alzheimer’s ...
Smith FD +14 more
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Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins [PDF]
Frontiers in Pharmacology, 2015 Cyclic AMP is a ubiquitous intracellular second messenger involved in the regulation of a wide variety of cellular processes, a majority of which act through the cAMP - protein kinase A (PKA) signalling pathway and involve PKA phosphorylation of specific
Ana Isabel C. Calejo, Kjetil eTaskén
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A-Kinase Anchoring Proteins in Cardiac Myocytes and Their Roles in Regulating Calcium Cycling [PDF]
Cells, 2023 The rate of calcium cycling and calcium transient amplitude are critical determinants for the efficient contraction and relaxation of the heart. Calcium-handling proteins in the cardiac myocyte are altered in heart failure, and restoring the proper ...
Hariharan Subramanian +1 more
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The role of A-kinase anchoring proteins in cardiovascular diseases and recent advances [PDF]
Frontiers in Cell and Developmental BiologyCardiovascular diseases are a major global health concern, leading to high morbidity, mortality, and disability rates. Scaffold proteins, particularly A-kinase anchoring proteins (AKAPs), play a crucial role in signal transduction within the ...
Xu Zhang +4 more
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A-kinase anchoring proteins: scaffolding proteins in the heart.
Am J Physiol Heart Circ Physiol, 2011 The pleiotropic cyclic nucleotide cAMP is the primary second messenger responsible for autonomic regulation of cardiac inotropy, chronotropy, and lusitropy. Under conditions of prolonged catecholaminergic stimulation, cAMP also contributes to the induction of both cardiac myocyte hypertrophy and apoptosis.
Diviani D +3 more
europepmc +6 more sources
A-kinase anchoring proteins that regulate cardiac remodeling. [PDF]
J Cardiovasc Pharmacol, 2011 In response to injury or stress, the adult heart undergoes maladaptive changes, collectively defined as pathological cardiac remodeling. Here, we focus on the role of A-kinase anchoring proteins (AKAPs) in 3 main areas associated with cardiac remodeling ...
Carnegie GK, Burmeister BT.
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Mitochondrial A‐kinase anchoring proteins in cardiac ventricular myocytes [PDF]
Physiological Reports, 2021 Compartmentation of cAMP signaling is a critical factor for maintaining the integrity of receptor‐specific responses in cardiac myocytes. This phenomenon relies on various factors limiting cAMP diffusion.
Rinzhin T. Sherpa +6 more
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A-kinase anchoring proteins take shape. [PDF]
Current Opinion in Cell Biology, 2007 A-kinase anchoring proteins (AKAPs) are signaling scaffolds that contribute to various aspects of cAMP signaling. They do this by tethering protein kinase-A to specific subcellular sites, thereby focusing its activity toward relevant substrates.
D. Beene, John D. Scott
semanticscholar +3 more sources