Results 21 to 30 of about 115,019,931 (299)
Architectural and functional roles of A kinase-anchoring proteins in cAMP microdomains. [PDF]
J Gen Physiol, 2014 ### Introduction The cAMP signaling pathway is one of the best-characterized transduction systems because of its presence in all tissues and systems. Since the discovery of the second messenger cAMP in the 1950s, it is widely appreciated that numerous ...
Kapiloff MS, Rigatti M, Dodge-Kafka KL.
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Organizing signal transduction through A-kinase anchoring proteins (AKAPs). [PDF]
FEBS J, 2010 A fundamental role for protein–protein interactions in the organization of signal transduction pathways is evident. Anchoring, scaffolding and adapter proteins function to enhance the precision and directionality of these signaling events by bringing ...
Logue JS, Scott JD.
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A-kinase anchoring proteins as potential drug targets. [PDF]
Br J Pharmacol, 2012 A‐kinase anchoring proteins (AKAPs) crucially contribute to the spatial and temporal control of cellular signalling. They directly interact with a variety of protein binding partners and cellular constituents, thereby directing pools of signalling components to defined locales.
Tröger J +3 more
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A-kinase anchoring proteins and neuronal signaling mechanisms. [PDF]
Genes & Development, 2003 The rapid and reversible phosphorylation of proteins catalyzed by protein kinases and protein phosphatases is a well recognized mechanism of regulation in cells.
Graeme K. Carnegie, John D. Scott
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Emerging roles of A-kinase anchoring proteins in cardiovascular pathophysiology
Biochimica Et Biophysica Acta - Molecular Cell Research, 2016 Dario Diviani
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FEBS Letters, 2023 Cilia are microtubule‐based sensory organelles present in a number of eukaryotic cells. Mutations in the genes encoding ciliary proteins cause ciliopathies in humans.
Venkatramanan G. Rao +6 more
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Cells, 2022 Protein kinase A (PKA) is a key nodal signaling molecule that regulates a wide range of cellular functions in the cytosol and mitochondria. The distribution of A-kinase anchoring proteins that tether PKA, the local interaction with degradation molecules,
Noa Kirschner Peretz +3 more
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A-Kinase Anchoring Protein 2 Promotes Protection against Myocardial Infarction
Cells, 2021 Myocardial infarction (MI) is a leading cause of maladaptive cardiac remodeling and heart failure. In the damaged heart, loss of function is mainly due to cardiomyocyte death and remodeling of the cardiac tissue.
Darko Maric +5 more
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Protein Kinase A Anchoring [PDF]
Journal of Biological Chemistry, 1997 Specificity is perhaps the most enigmatic property of hormonemediated signaling pathways, especially when one considers that more than 30 hormones employ the ubiquitous second messengers, Ca, phospholipid, or cAMP, to relay messages from the cell membrane to intracellular effectors.
M L, Dell'Acqua, J D, Scott
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