Results 31 to 40 of about 115,019,931 (299)

Kinase-anchoring proteins and the intracellular targeting of cyclic adenosine monophosphate (cAMP)-dependent protein kinase

, 2007
Kinase anchoring proteins (AKAPs) are a family of structurally diverse multidomain proteins classified solely by their ability to bind cAMP-dependent protein kinase/protein kinase A (PKA).
Alison Jane Davis (7656008)
core   +6 more sources

A-kinase anchoring proteins: Molecular regulators of the cardiac stress response

Biochimica Et Biophysica Acta - Molecular Cell Research, 2013
Sabrina Cavin, Dario Diviani
exaly   +2 more sources

Colocalization of protein kinase A with adenylyl cyclase enhances protein kinase A activity during induction of long-lasting long-term-potentiation. [PDF]

PLoS Computational Biology, 2011
The ability of neurons to differentially respond to specific temporal and spatial input patterns underlies information storage in neural circuits. One means of achieving spatial specificity is to restrict signaling molecules to particular subcellular ...
Myungsook Kim, Alan Jung Park, Robbert Havekes, Andrew Chay, Leonardo Antonio Guercio, Rodrigo Freire Oliveira, Rodrigo Freire Oliveira, Ted Abel, Kim T Blackwell   +8 more
doaj   +1 more source

Anchoring proteins encounter mitotic kinases [PDF]

Cell Cycle, 2013
Defective progression of cells through mitosis permits an accumulation of genetic defects that lead to aneuploidy. Cells in a state of aneuploidy acquire mutations that eventually cause their transformation from normal cells into cancer.1 Recent evidence suggests that perturbing the spatial and temporal pattern of cell division can enhance such ...
Canton, David A., Scott, John D.
openaire   +2 more sources

Cypher/ZASP Is a Novel A-kinase Anchoring Protein [PDF]

Journal of Biological Chemistry, 2013
PKA signaling is important for the post-translational modification of proteins, especially those in cardiomyocytes involved in cardiac excitation-contraction coupling. PKA activity is spatially and temporally regulated through compartmentalization by protein kinase A anchoring proteins.
Lin, Changsong, Guo, Xiaogang, Lange, Stephan, Liu, Jie, Ouyang, Kunfu, Yin, Xiang, Jiang, Liujun, Cai, Yibo, Mu, Yongxin, Sheikh, Farah, Ye, Sheng, Chen, Ju, Ke, Yuehai, Cheng, Hongqiang   +13 more
openaire   +4 more sources

Epac Function and cAMP Scaffolds in the Heart and Lung

Journal of Cardiovascular Development and Disease, 2018
Evidence collected over the last ten years indicates that Epac and cAMP scaffold proteins play a critical role in integrating and transducing multiple signaling pathways at the basis of cardiac and lung physiopathology. Some of the deleterious effects of
Marion Laudette, Haoxiao Zuo, Frank Lezoualc’h, Martina Schmidt   +3 more
doaj   +1 more source

PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome [PDF]

, 2012
Previous work has shown that the protein kinase A (PKA)–regulated phosphodiesterase (PDE) 4D3 binds to A kinase–anchoring proteins (AKAPs). One such protein, AKAP9, localizes to the centrosome.
Stangherlin, A, Surdo, N. C., Terrin, A., Sawa, A., Terrin, A, N. E. Jordanides, A. Stangherlin, Monterisi, S, Mountford, JC, Monterisi, S., A. Terrin, Surdo, NC, Stefania Monterisi, Akira Sawa, Mongillo, M, Jordanides, NE, Alessandra Stangherlin, Koschinski, A, Manuela Zaccolo, Joanne C. Mountford, Nicoletta C. Surdo, Niove E. Jordanides, Jordanides, N..E., Anna Zoccarato, Koschinski, A., Zaccolo, Manuela, MONGILLO, MARCO, Andreas Koschinski, Anna Terrin, M. Zaccolo, Sawa, A, A. Koschinski, A. Zoccarato, Zoccarato, A., Zaccolo, M., A. Sawa, Mountford, J.C., Zoccarato, A, N. C. Surdo, Marco Mongillo, Stangherlin, A., Mongillo, M., S. Monterisi, J. C. Mountford   +43 more
core   +1 more source

Identification and functional characterization of A-kinase anchoring proteins

, 2023
Compartmentalization of signal transduction enzymes is an important mechanism for imparting cellular signaling specificity. This occurs through the interaction of enzymes with scaffolding or anchoring proteins.
Alto, Neal
core   +1 more source

Gravin orchestrates protein kinase A and 2-adrenergic receptor signaling critical for synaptic plasticity and memory [PDF]

, 2012
A kinase-anchoring proteins (AKAPs) organize compartmentalized pools of protein kinase A (PKA) to enable localized signaling events within neurons. However, it is unclear which of the many expressed AKAPs in neurons target PKA to signaling complexes ...
Huang, T., Day, Jonathan P., Day, Jonathan P, Baillie, George S., Guercio, L.A., Luczak, V., Nie, T., Scott, J.D., Guercio, Leonardo A., Baillie, G.S., Abel, T., Gelman, I.H., Park, Alan J, Canton, David A., Scott, John D., Havekes, R., Nie, Ting, Gelman, Irwin H, Canton, D.A., Park, Alan J., Grimes, Quinn, Grimes, Q., Luczak, Vincent G, Havekes, Robbert, Park, A.J., Guercio, Leonardo A, Baillie, George S, Abel, Ted, Gelman, Irwin H., Luczak, Vincent, Day, J.P., Canton, David A, Huang, Ted   +32 more
core   +1 more source

Function of Adenylyl Cyclase in Heart: the AKAP Connection

Journal of Cardiovascular Development and Disease, 2018
Cyclic adenosine monophosphate (cAMP), synthesized by adenylyl cyclase (AC), is a universal second messenger that regulates various aspects of cardiac physiology from contraction rate to the initiation of cardioprotective stress response pathways.
Tanya A. Baldwin, Carmen W. Dessauer
doaj   +1 more source