Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteins. [PDF]
Journal of Molecular Endocrinology, 2010 Protein phosphorylation is the most common post-translational modification observed in cell signaling and is controlled by the balance between protein kinase and phosphatase activities. The cAMP–protein kinase A (PKA) pathway is one of the most studied and well-known signal pathways.
G. Pidoux, K. Taskén
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Scaffolding during the cell cycle by A-kinase anchoring proteins. [PDF]
Pflugers Arch, 2015 Cell division relies on coordinated regulation of the cell cycle. A process including a well-defined series of strictly regulated molecular mechanisms involving cyclin-dependent kinases, retinoblastoma protein, and polo-like kinases. Dysfunctions in cell
Han B, Poppinga WJ, Schmidt M.
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The Role of A-Kinase Anchoring Proteins for Inhibitory cAMP Signalling in Platelets [PDF]
CellsPlatelets are small circulating blood cells that mediate haemostasis and thrombosis. Platelets respond to vascular damage by adhesion, granule release, and aggregation.
Shannon Barkey, Albert Smolenski
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A-Kinase Anchoring Proteins Diminish TGF-β1/Cigarette Smoke-Induced Epithelial-To-Mesenchymal Transition [PDF]
Cells, 2020 Epithelial-to-mesenchymal transition (EMT) plays a role in chronic obstructive pulmonary diseases (COPD). Cyclic adenosine monophosphate (cAMP) can inhibit transforming growth factor-β1 (TGF-β1) mediated EMT. Although compartmentalization via A-
Haoxiao Zuo +9 more
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Compartmentalization role of A-kinase anchoring proteins (AKAPs) in mediating protein kinase A (PKA) signaling and cardiomyocyte hypertrophy. [PDF]
Int J Mol Sci, 2014 The Beta-adrenergic receptors (β-ARs) stimulation enhances contractility through protein kinase-A (PKA) substrate phosphorylation. This PKA signaling is conferred in part by PKA binding to A-kinase anchoring proteins (AKAPs).
Rababa'h A +5 more
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A-kinase-anchoring proteins [PDF]
Journal of Cell Science, 2005 Highly organized molecular complexes determine the precise location and timing of the signal transduction events that occur downstream of cell surface receptor activation ([Pawson and Nash, 2003][1]). One set of scaffolding molecules that organize such complexes is a family of proteins known as A-
L. Langeberg, John D. Scott
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Inhibition of PKA anchoring to A-kinase anchoring proteins impairs consolidation and facilitates extinction of contextual fear memories [PDF]
Neurobiology of Learning and Memory, 2008 Both genetic and pharmacological studies demonstrated that contextual fear conditioning is critically regulated by cyclic AMP-dependent protein kinase (PKA).
Eddy A Van der Zee +2 more
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A-kinase anchoring proteins: getting to the heart of the matter. [PDF]
Circulation, 2010 The heart is a sophisticated organ that continuously pumps blood to ensure that oxygen and nutrients reach the brain, other organs, and peripheral tissue. The right side of the heart pumps blood to the lungs, where oxygen is taken up and carbon dioxide is removed.
Scott JD, Santana LF.
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Kinase-anchoring proteins in ciliary signal transduction. [PDF]
Biochem J, 2021 Historically, the diffusion of chemical signals through the cell was thought to occur within a cytoplasmic soup bounded by the plasma membrane. This theory was predicated on the notion that all regulatory enzymes are soluble and moved with a Brownian motion. Although enzyme compartmentalization was initially rebuffed by biochemists as a ‘last refuge of
Gopalan J, Wordeman L, Scott JD.
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Role of a-kinase anchoring proteins (AKAPs) in reproduction. [PDF]
Frontiers in Bioscience, 2011 Rapid spatio-temporal organized intracellular signaling is a pivotal mechanism for regulation of functions in many cells, in particular in the female and male gametes, in which functional regulation through rapid increases in protein content is not possible since the mechanisms of transcription/translation are somehow frozen due to meiosis block or DNA
M. Luconi +3 more
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