Results 51 to 60 of about 115,019,931 (299)

Role for A Kinase-anchoring Proteins (AKAPS) in Glutamate Receptor Trafficking and Long Term Synaptic Depression*

Journal of Biological Chemistry, 2005
Expression of N-methyl d-aspartate (NMDA) receptor-dependent homosynaptic long term depression at synapses in the hippocampus and neocortex requires the persistent dephosphorylation of postsynaptic protein kinase A substrates. An attractive mechanism for
E. Snyder, M. Colledge, R. Crozier, Wendy S. Chen, John D. Scott, M. Bear   +5 more
semanticscholar   +1 more source

Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79.

Journal of Biological Chemistry, 1992
Postsynaptic densities (PSD) are a network of proteins located on the internal surface of excitatory synapses just inside the postsynaptic membrane. Enzymes associated with the PSD are optimally positioned to respond to signals transduced across the ...
D. W. Carr, Renata E. Stofko-Hahn, I. D. Fraser, R. Cone, J. D. Scott   +4 more
semanticscholar   +1 more source

Protein kinase A activity and anchoring are required for ovarian cancer cell migration and invasion. [PDF]

PLoS ONE, 2011
Epithelial ovarian cancer (EOC) is the deadliest of the gynecological malignancies, due in part to its clinically occult metastasis. Therefore, understanding the mechanisms governing EOC dissemination and invasion may provide new targets for ...
Andrew J McKenzie, Shirley L Campbell, Alan K Howe   +2 more
doaj   +1 more source

Control of PKA stability and signalling by RING ligase praja2 [PDF]

, 2010
Ligand-mediated activation of G-Protein Coupled Receptors (GPCRs) mobilises compartmentalised pulses of second messengers like cAMP. The main cellular effector of cAMP is Protein Kinase A (PKA) which is assembled as inactive holoenzyme consisting of two ...
Lignitto, Luca
core   +1 more source

Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation

eLife, 2013
Anchoring proteins sequester kinases with their substrates to locally disseminate intracellular signals and avert indiscriminate transmission of these responses throughout the cell.
F Donelson Smith, Steve L Reichow, Jessica L Esseltine, Dan Shi, Lorene K Langeberg, John D Scott, Tamir Gonen   +6 more
doaj   +1 more source

A-Kinase Anchoring Proteins: From protein complexes to physiology and disease

IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2009
Protein scaffold complexes are a key mechanism by which a common signaling pathway can serve many different functions. Sequestering a signaling enzyme to a specific subcellular environment not only ensures that the enzyme is near its relevant targets ...
Graeme K. Carnegie, C. Means, J. D. Scott   +2 more
semanticscholar   +1 more source

RACK(1) to the future – a historical perspective [PDF]

, 2013
This perspective summarises the first and long overdue RACK1 meeting held at the University of Limerick, Ireland, May 2013, in which RACK1’s role in the immune system, the heart and the brain were discussed and its contribution to disease states such as ...
Kiely, Patrick, Ron, D., George S Baillie, Baillie, George S., David R. Adams (2135944), Adams, Dave, O’Connor, Rosemary, Adams, David, Baillie, G.S., O'Connor, R, Dorit Ron, Long, Aideen, Rosemary O’Connor, George S. Baillie (2200696), Adams, David R, Adams, DR, Ron, Dorit, Kiely, PA, Kiely, Patrick A, OConnor, Rosemary, Adams, David R., Adams, D.R., Baillie, GS, Patrick A. Kiely (12579106), O'Connor, Rosemary, Dorit Ron (741576), David R Adams, Long, A, Baillie, George, Aideen Long (2238037), Baillie, George S, O\u27Connor, Rosemary, Kiely, Patrick A., Patrick A Kiely, O’Connor, R., Kiely, P.A., Aideen Long, Long, A.   +37 more
core   +1 more source

Interacting protein kinases involved in the regulation of flagellar length [PDF]

, 2006
A striking difference of the life stages of the protozoan parasite Leishmania is a long flagellum in the insect stage promastigotes and a rudimentary organelle in the mammalian amastigotes.
Scholz, M., Melzer, I.M., Erdmann, M., Schmetz, C., Wiese, M.   +4 more
core   +4 more sources

Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs)

BMC Cancer, 2018
Background Tumor heterogeneity in breast cancer tumors is today widely recognized. Most of the available knowledge in genetic variation however, relates to the primary tumor while metastatic lesions are much less studied.
Una Kjällquist, Rikard Erlandsson, Nicholas P. Tobin, Amjad Alkodsi, Ikram Ullah, Gustav Stålhammar, Eva Karlsson, Thomas Hatschek, Johan Hartman, Sten Linnarsson, Jonas Bergh   +10 more
doaj   +1 more source

A novel protein kinase-like domain in a selenoprotein, widespread in the tree of life. [PDF]

, 2012
Selenoproteins serve important functions in many organisms, usually providing essential oxidoreductase enzymatic activity, often for defense against toxic xenobiotic substances.
Dudkiewicz, Małgorzata, Grynberg, Marcin, Pawłowski, Krzysztof, Szczepińska, Teresa   +3 more
core   +2 more sources