Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1 [PDF]
, 2016 Brief periods of sleep loss have long-lasting consequences such as impaired memory consolidation. Structural changes in synaptic connectivity have been proposed as a substrate of memory storage.
Abel, Ted +14 more
core +6 more sources
A Constraint on cAMP Signaling [PDF]
Neuron, 2004 AbstractStudies in invertebrates and vertebrates have demonstrated a critical role for cAMP signaling and adenylyl cyclase (AC) activity in learning and memory. In this issue of Neuron, Pineda et al. show that in the hippocampus, reduction of AC activity via the inhibitory G protein Gi is critical for memory formation, suggesting that a balance of ...
openaire +2 more sources
Elevated intracellular cAMP exacerbates vulnerability to oxidative stress in optic nerve head astrocytes. [PDF]
, 2018 Glaucoma is characterized by a progressive loss of retinal ganglion cells and their axons, but the underlying biological basis for the accompanying neurodegeneration is not known.
Bu, Jung Hyun +8 more
core +2 more sources
cAMP Signals in Drosophila Motor Neurons Are Confined to Single Synaptic Boutons
Cell Reports, 2016 Summary: The second messenger cyclic AMP (cAMP) plays an important role in synaptic plasticity. Although there is evidence for local control of synaptic transmission and plasticity, it is less clear whether a similar spatial confinement of cAMP signaling
Isabella Maiellaro +3 more
doaj +1 more source
Haematologica, 2020 Prostacyclin (PGI2) controls platelet activation and thrombosis through a cyclic adenosine monophosphate (cAMP) signaling cascade. However, in patients with cardiovascular diseases this protective mechanism fails for reasons that are unclear.
Martin Berger +9 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 The ascomycete fungus Colletotrichum scovillei causes severe anthracnose disease on the fruit of sweet pepper and chili pepper (Capsicum annuum L.) worldwide. Understanding the biology of C.
Teng Fu, Hyun-Hoo Park, Kyoung Su Kim
doaj +1 more source
Targeting protein–protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease [PDF]
, 2013 The cAMP signaling system can trigger precise physiological cellular responses that depend on the fidelity of many protein–protein interactions, which act to bring together signaling intermediates at defined locations within cells.
Brunton +8 more
core +1 more source
A link among schizophrenia, diabetes, and asthma: Role of Ca2+/cAMP signaling
Brain Circulation, 2020 Asthma has been associated with an increased risk for developing schizophrenia. In addition, schizophrenia has been associated with an increased risk for developing type 2 diabetes mellitus, resulting in an elevated cardiovascular risk and in a limited ...
Leandro Bueno Bergantin
doaj +1 more source
cAMP-PDE signaling in COPD: Review of cellular, molecular and clinical features
Biochemistry and Biophysics Reports, 2023 Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death among non-contagious diseases in the world. PDE inhibitors are among current medicines prescribed for COPD treatment of which, PDE-4 family is the predominant PDE isoform ...
Yazdan Hasani Nourian +7 more
doaj +1 more source
Multiparametric imaging of spatio-temporal cAMP signaling, transmembrane potential, and intracellular calcium in the intact heart. [PDF]
iScienceSummary: The spatiotemporal dynamics of intracellular second messengers and signaling molecules, including cyclic adenosine monophosphate (cAMP), have been studied extensively in isolated cardiomyocytes using Förster resonance energy transfer (FRET ...
Lee IE +5 more
europepmc +2 more sources