Results 31 to 40 of about 1,301,166 (250)

Evolution of size and pattern in the social amoebas [PDF]

, 2007
A fundamental goal of biology is to understand how novel phenotypes evolved through changes in existing genes. The Dictyostelia or social amoebas represent a simple form of multicellularity, where starving cells aggregate to build fruiting structures ...
Schaap, P.; id_orcid
core   +1 more source

Phosphodiesterases 3 and 4 Differentially Regulate the Funny Current, If, in Mouse Sinoatrial Node Myocytes

Journal of Cardiovascular Development and Disease, 2017
Cardiac pacemaking, at rest and during the sympathetic fight-or-flight response, depends on cAMP (3′,5′-cyclic adenosine monophosphate) signaling in sinoatrial node myocytes (SAMs).
Joshua R. St. Clair, Eric D. Larson, Emily J. Sharpe, Zhandi Liao, Catherine Proenza   +4 more
doaj   +1 more source

Phosphodiesterase Inhibitors Suppress Lactobacillus casei Cell-Wall-Induced NF-κB and MAPK Activations and Cell Proliferation through Protein Kinase A—or Exchange Protein Activated by cAMP-Dependent Signal Pathway

The Scientific World Journal, 2012
Specific strains of Lactobacillus have been found to be beneficial in treating some types of diarrhea and vaginosis. However, a high mortality rate results from underlying immunosuppressive conditions in patients with Lactobacillus casei bacteremia ...
Takekatsu Saito, Naotoshi Sugimoto, Kunio Ohta, Tohru Shimizu, Kaori Ohtani, Yuko Nakayama, Taichi Nakamura, Yashiaki Hitomi, Hiroyuki Nakamura, Shoichi Koizumi, Akihiro Yachie   +10 more
doaj   +1 more source

The old second messenger cAMP teams up with novel cell death mechanisms: potential translational therapeutical benefit for Alzheimer’s disease and Parkinson’s disease

Frontiers in Physiology, 2023
Alzheimer’s disease (AD) and Parkinson’s disease (PD) represent the most prevalent neurodegenerative disorders severely impacting life expectancy and quality of life of millions of people worldwide.
Tong Zhang, Tong Zhang, Minh D. A. Luu, Amalia M. Dolga, Ulrich L. M. Eisel, Martina Schmidt, Martina Schmidt   +6 more
doaj   +1 more source

The genetically encoded tool set for investigating cAMP: more than the sum of its parts

Frontiers in Pharmacology, 2015
Intracellular fluctuations of the second messenger cyclic AMP (cAMP) are regulated with spatial and temporal precision. This regulation is supported by the sophisticated arrangement of cyclases, phosphodiesterases, anchoring proteins and receptors for ...
Neha ePatel, Matthew G Gold
doaj   +1 more source

GABA signaling in the thalamus [PDF]

, 2004
Inhibition of neuronal activity in networks of the mammalian central nervous system is essential for all fundamental brain functions, ranging from perception, to consciousness, to action.
Frère, Samuel
core   +1 more source

Spatiotemporal regulation of cAMP signaling controls the human trophoblast fusion

Frontiers in Pharmacology, 2015
During human placentation, mononuclear cytotrophoblasts fuse to form multinucleated syncytia ensuring hormonal production and nutrient exchanges between the maternal and fetal circulation. Syncytial formation is essential for the maintenance of pregnancy
Pascale eGerbaud, Kjetil eTaskén, Guillaume ePidoux   +2 more
doaj   +1 more source

Pharmacological Programming of Endosomal Signaling Activated by Small Molecule Ligands of the Follicle Stimulating Hormone Receptor

Frontiers in Pharmacology, 2020
Follicle-stimulating hormone receptor (FSHR) is a G protein-coupled receptor (GPCR) with pivotal roles in reproduction. One key mechanism dictating the signal activity of GPCRs is membrane trafficking.
Silvia Sposini, Silvia Sposini, Francesco De Pascali, Rachel Richardson, Niamh S. Sayers, David Perrais, Henry N. Yu, Stephen Palmer, Selva Nataraja, Eric Reiter, Aylin C. Hanyaloglu   +10 more
doaj   +1 more source

cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission. [PDF]

, 2015
Blocking Plasmodium falciparum transmission to mosquitoes has been designated a strategic objective in the global agenda of malaria elimination. Transmission is ensured by gametocyte-infected erythrocytes (GIE) that sequester in the bone marrow and at ...
Odile Mercereau-Puijalon, B. Naissant, F. Breil, Vernick Kenneth, Corbett Yolanda, Vernick, Kenneth D, Lavazec Catherine, Naissant Bernina, Duffier, Yoann, Naissant, Bernina, Eloise Thompson, Audrey Lorthiois (545164), Baker, David, A, Corbett, Yolanda, Duffier Yoann, Yolanda Corbett, Ghania Ramdani (676819), Vernick, Kenneth, Mercereau-Puijalon, Odile, Ramdani, Ghania, Yoann Duffier, Langsley Gordon, Ghania Ramdani, E. Thompson, Y. Corbett, K. Vernick, Audrey Lorthiois, Catherine Lavazec (106835), Dupuy, Florian, Gordon Langsley (85708), Gordon Langsley, Taramelli, Donatella, Baker, David ,, Florian Dupuy (616138), Lorthiois, Audrey, Bernina Naissant, Lavazec, Catherine, Dupuy Florian, Baker, David A, Catherine Lavazec, Odile Mercereau-Puijalon (58234), Mercereau-Puijalon Odile, David A Baker, Cummings Ross, Ross Cummings (736307), O. Mercereau Puijalon, Cummings, Ross, D. A. Baker, F. Dupuy, Florence Breil, Lorthiois Audrey, G. Langsley, Thompson Eloise, Y. Duffier, Florian Dupuy, Kenneth Vernick (736310), David A. Baker (122252), Baker, David,, A. Lorthiois, Breil Florence, Bernina Naissant (268019), R. Cummings, G. Ramdani, Yoann Duffier (736308), Donatella Taramelli, Ross Cummings, D. Taramelli, Ramdani Ghania, Taramelli Donatella, Langsley, Gordon, Baker David A., Kenneth Vernick, Thompson, Eloise, Florence Breil (736306), C. Lavazec, Eloise Thompson (376344), Yolanda Corbett (736309), Breil, Florence, Donatella Taramelli (736311)   +78 more
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The mechanism and control of Jagged1 expression in Sertoli cells

Regenerative Therapy, 2016
The regulation of Sertoli cells by some hormones and signaling factors is important for normal spermatogenesis. Notch signaling is considered to be necessary for normal spermatogenesis in mouse.
Ryu Okada, Taro Hara, Tomomi Sato, Nobuhiko Kojima, Yukio Nishina   +4 more
doaj   +1 more source