Results 51 to 60 of about 308,089 (303)

Phosphodiesterases 3 and 4 Differentially Regulate the Funny Current, If, in Mouse Sinoatrial Node Myocytes

Journal of Cardiovascular Development and Disease, 2017
Cardiac pacemaking, at rest and during the sympathetic fight-or-flight response, depends on cAMP (3′,5′-cyclic adenosine monophosphate) signaling in sinoatrial node myocytes (SAMs).
Joshua R. St. Clair, Eric D. Larson, Emily J. Sharpe, Zhandi Liao, Catherine Proenza   +4 more
doaj   +1 more source

Ixazomib enhances parathyroid hormone-induced β-catenin/T-cell factor signaling by dissociating β-catenin from the parathyroid hormone receptor. [PDF]

, 2017
The anabolic action of PTH in bone is mostly mediated by cAMP/PKA and Wnt-independent activation of β-catenin/T-cell factor (TCF) signaling. β-Catenin switches the PTH receptor (PTHR) signaling from cAMP/PKA to PLC/PKC activation by binding to the PTHR ...
Lei, Hong, Qiang, Ya-Wei, Wang, Bin, Yang, Yanmei   +3 more
core   +2 more sources

The old second messenger cAMP teams up with novel cell death mechanisms: potential translational therapeutical benefit for Alzheimer’s disease and Parkinson’s disease

Frontiers in Physiology, 2023
Alzheimer’s disease (AD) and Parkinson’s disease (PD) represent the most prevalent neurodegenerative disorders severely impacting life expectancy and quality of life of millions of people worldwide.
Tong Zhang, Tong Zhang, Minh D. A. Luu, Amalia M. Dolga, Ulrich L. M. Eisel, Martina Schmidt, Martina Schmidt   +6 more
doaj   +1 more source

Separate roles of PKA and EPAC in renal function unraveled by the optogenetic control of cAMP levels in vivo [PDF]

, 2013
Cyclic AMP (cAMP) is a ubiquitous second messenger that regulates a variety of essential processes in diverse cell types, functioning via cAMP-dependent effectors such as protein kinase A (PKA) and/or exchange proteins directly activated by cAMP (EPAC ...
Akbari, Baillie, Beyenbach, Beyenbach, Bos, Bos, Bos, Brand, Börner, Cabrero, Chepurny, Coast, Coast, Coast, Coast, Dames, Davies, Day, de Rooij, Dow, Dow, Dow, Dow, Enserink, Evans, Gloerich, Guo, Hallows, Hector, Iijima–Ando, Johnson, Johnson, Kalderon, Kandel, Kaufmann, Kaupp, Kerr, Laroche–Joubert, MacPherson, O'Donnell, O'Donnell, Parks, Pastor–Soler, Pastor–Soler, Poulsen, Radford, Rein, Rosay, Ryu, Ryu, Schröder–Lang, Stierl, Stokman, Sözen, Terhzaz, Terhzaz, Torrie, Weissenberger, Wong, Zaccolo, Zaccolo   +60 more
core   +1 more source

Endosomal generation of cAMP in GPCR signaling [PDF]

Nature Chemical Biology, 2014
It has been widely assumed that the production of the ubiquitous second messenger cyclic AMP, which is mediated by cell surface G protein–coupled receptors (GPCRs), and its termination take place exclusively at the plasma membrane. Recent studies reveal that diverse GPCRs do not always follow this conventional paradigm.
Vilardaga, Jean-Pierre, Jean-Alphonse, Frédéric, Gardella, Thomas   +2 more
openaire   +2 more sources

The ever unfolding story of cAMP signaling in trypanosomatids: vive la difference! [PDF]

, 2015
Kinetoplastids are unicellular, eukaryotic, flagellated protozoans containing the eponymous kinetoplast. Within this order, the family of trypanosomatids are responsible for some of the most serious human diseases, including Chagas disease (Trypanosoma ...
De Koning, Harry P., Kalejaiye, Titilola D., Tagoe, Daniel N. A.   +2 more
core   +1 more source

Phosphodiesterase Inhibitors Suppress Lactobacillus casei Cell-Wall-Induced NF-κB and MAPK Activations and Cell Proliferation through Protein Kinase A—or Exchange Protein Activated by cAMP-Dependent Signal Pathway

The Scientific World Journal, 2012
Specific strains of Lactobacillus have been found to be beneficial in treating some types of diarrhea and vaginosis. However, a high mortality rate results from underlying immunosuppressive conditions in patients with Lactobacillus casei bacteremia ...
Takekatsu Saito, Naotoshi Sugimoto, Kunio Ohta, Tohru Shimizu, Kaori Ohtani, Yuko Nakayama, Taichi Nakamura, Yashiaki Hitomi, Hiroyuki Nakamura, Shoichi Koizumi, Akihiro Yachie   +10 more
doaj   +1 more source

Selective inhibition of histamine-evoked Ca2+ signals by compartmentalized cAMP in human bronchial airway smooth muscle cells. [PDF]

, 2018
Intracellular Ca2+ and cAMP typically cause opposing effects on airway smooth muscle contraction. Receptors that stimulate these pathways are therapeutic targets in asthma and chronic obstructive pulmonary disease.
Dale, Philippa, Dowling, Mark R, Head, Victoria, Taylor, Colin W   +3 more
core   +1 more source

Pharmacological Programming of Endosomal Signaling Activated by Small Molecule Ligands of the Follicle Stimulating Hormone Receptor

Frontiers in Pharmacology, 2020
Follicle-stimulating hormone receptor (FSHR) is a G protein-coupled receptor (GPCR) with pivotal roles in reproduction. One key mechanism dictating the signal activity of GPCRs is membrane trafficking.
Silvia Sposini, Silvia Sposini, Francesco De Pascali, Rachel Richardson, Niamh S. Sayers, David Perrais, Henry N. Yu, Stephen Palmer, Selva Nataraja, Eric Reiter, Aylin C. Hanyaloglu   +10 more
doaj   +1 more source

Compartmentalisation of cAMP and Ca2+ signals

Current Opinion in Cell Biology, 2002
The available knowledge concerning second messengers such as Ca(2+) and cAMP has grown immensely in the past few years. The concept of tight spatial compartmentalisation of these signals within cells has led to more refined models of intracellular signalling.
Zaccolo, M, Magalhães, P, Pozzan, T
openaire   +3 more sources