Results 71 to 80 of about 308,089 (303)

Role of cAMP Signaling in the Survival and Infectivity of the Protozoan Parasite, Leishmania donovani [PDF]

, 2011
Leishmania donovani, while invading macrophages, encounters striking shift in temperature and pH (from 22◦ C and pH 7.2 to 37◦ C and pH 5.5), which act as the key environmental trigger for differentiation, and increases cAMP level and cAMP-mediated ...
Biswas, Arumina, Bhattacharya, Arijit, Das, Pijush K   +2 more
core   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Characterization of the Signaling Modalities of Prostaglandin E2 Receptors EP2 and EP4 Reveals Crosstalk and a Role for Microtubules

Frontiers in Immunology, 2021
Prostaglandin E2 (PGE2) is a lipid mediator that modulates the function of myeloid immune cells such as macrophages and dendritic cells (DCs) through the activation of the G protein-coupled receptors EP2 and EP4. While both EP2 and EP4 signaling leads to
Ward Vleeshouwers, Koen van den Dries, Sandra de Keijzer, Ben Joosten, Diane S. Lidke, Diane S. Lidke, Alessandra Cambi   +6 more
doaj   +1 more source

A predictive computational model reveals that GIV/girdin serves as a tunable valve for EGFR-stimulated cyclic AMP signals. [PDF]

, 2019
Cellular levels of the versatile second messenger cyclic (c)AMP are regulated by the antagonistic actions of the canonical G protein → adenylyl cyclase pathway that is initiated by G-protein-coupled receptors (GPCRs) and attenuated by phosphodiesterases (
Getz, Michael, Ghosh, Pradipta, Rangamani, Padmini, Sahoo, Debashish, Swanson, Lee   +4 more
core   +1 more source

MyD88 and TRIF mediate the cyclic adenosine monophosphate (cAMP) induced corticotropin releasing hormone (CRH) expression in JEG3 choriocarcinoma cell line [PDF]

, 2009
Background Classically protein kinase A (PKA) and transcription factor activator protein 1 (AP-1) mediate the cyclic AMP (cAMP) induced-corticotrophin releasing hormone (CRH) expression in the placenta.
Adrian F Gombart, Andy Uh, Catherine Bresee, Charles F Simmons, Hande Kocak, Nasif Khoury, Ozlem Equils, Richard C Nicholson   +7 more
core   +2 more sources

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

The Spatiotemporal Regulation of cAMP Signaling in Blood Platelets—Old Friends and New Players [PDF]

, 2015
Atherothrombosis, the pathology underlying numerous cardiovascular diseases, is a major cause of death globally. Hyperactive blood platelets play a key role in the atherothrombotic process through the release of inflammatory mediators and formation of ...
Aburima, Beck, Burgers, Burkhart, Carlson, Carr, Cooper, Delint-Ramirez, Dickinson, El-Daher, El-Daher, Feijge, Freson, Freson, Gachet, Geet, Gold, Gold, Hunter, Kinderman, Lissandron, Macphee, Manchev, Margarucci, Nuytens, Pidoux, Raslan, Raslan, Raslan, Roberts, Rondina, Rowley, Ruppelt, Sarma, Schillace, Schwarz, Scott, Scott, Smolenski, Stangherlin, Tasken, Wang, Wilson, Zaccolo, Zhang, Zhang   +45 more
core   +1 more source

Anchored cAMP signaling: Onward and upward – A short history of compartmentalized cAMP signal transduction

European Journal of Cell Biology, 2006
Intracellular signal transduction pathways require a high degree of spatial and temporal resolution in order to deliver the appropriate outputs. Specific signaling mediated by the ubiquitous second messenger cAMP and its effector, the cAMP-dependent protein kinase (PKA), is governed by the spatial organization of different pathway components by A ...
F Donelson, Smith, John D, Scott
openaire   +2 more sources

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source