Results 61 to 70 of about 308,089 (303)
The genetically encoded tool set for investigating cAMP: more than the sum of its parts
Frontiers in Pharmacology, 2015 Intracellular fluctuations of the second messenger cyclic AMP (cAMP) are regulated with spatial and temporal precision. This regulation is supported by the sophisticated arrangement of cyclases, phosphodiesterases, anchoring proteins and receptors for ...
Neha ePatel, Matthew G Gold
doaj +1 more source
Spatiotemporal regulation of cAMP signaling controls the human trophoblast fusion
Frontiers in Pharmacology, 2015 During human placentation, mononuclear cytotrophoblasts fuse to form multinucleated syncytia ensuring hormonal production and nutrient exchanges between the maternal and fetal circulation. Syncytial formation is essential for the maintenance of pregnancy
Pascale eGerbaud +2 more
doaj +1 more source
cAMP Signaling Enhances HIV-1 Long Terminal Repeat (LTR)-directed Transcription and Viral Replication in Bone Marrow Progenitor Cells. [PDF]
, 2017 CD34+ hematopoietic progenitor cells have been shown to be susceptible to HIV-1 infection, possibly due to a low-level expression of CXCR4, a coreceptor for HIV-1 entry.
Banerjee, Anupam +5 more
core +3 more sources
The mechanism and control of Jagged1 expression in Sertoli cells
Regenerative Therapy, 2016 The regulation of Sertoli cells by some hormones and signaling factors is important for normal spermatogenesis. Notch signaling is considered to be necessary for normal spermatogenesis in mouse.
Ryu Okada +4 more
doaj +1 more source
Data in Brief, 2022 Cyclic adenosine monophosphate (cyclic AMP) is a second messenger, which is involved in the regulation of various cellular processes, including neuronal firing rate, synaptic plasticity, axon formation and axon elongation in brain.
Seiko Kawata +2 more
doaj +1 more source
Caffeine Inhibits EGF-Stimulated Trophoblast Cell Motility through the Inhibition of mTORC2 and Akt. [PDF]
, 2012 Impaired trophoblast invasion is associated with pregnancy disorders such as early pregnancy loss and preeclampsia. There is evidence to suggest that the consumption of caffeine during pregnancy may increase the risk of pregnancy loss; however, little is
Alison E. Wallace +46 more
core +1 more source
cAMP-Dependent Signaling and Ovarian Cancer
Cells, 2022 cAMP-dependent pathway is one of the most significant signaling cascades in healthy and neoplastic ovarian cells. Working through its major effector proteins—PKA and EPAC—it regulates gene expression and many cellular functions. PKA promotes the phosphorylation of cAMP response element-binding protein (CREB) which mediates gene transcription, cell ...
Agnieszka Kilanowska +3 more
openaire +3 more sources
Cyclic AMP signaling promotes regeneration of cochlear synapses after excitotoxic or noise trauma
Frontiers in Cellular NeuroscienceIntroductionCochlear afferent synapses connecting inner hair cells to spiral ganglion neurons are susceptible to excitotoxic trauma on exposure to loud sound, resulting in a noise-induced cochlear synaptopathy (NICS).
Sriram Hemachandran +3 more
doaj +1 more source
Encystation stimuli sensing is mediated by adenylate cyclase AC2-dependent cAMP signaling in Giardia
Nature Communications, 2023 Protozoan parasites use cAMP signaling to precisely regulate the place and time of developmental differentiation, yet it is unclear how this signaling is initiated.
Han-Wei Shih +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source