Results 91 to 100 of about 308,089 (303)

Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1. [PDF]

, 2013
Obesity produces a chronic inflammatory state involving the NFκB pathway, resulting in persistent elevation of the noncanonical IκB kinases IKKε and TBK1.
Chang, Louise, Chiang, Shian-Huey, Leto, Dara, Mowers, Jonathan, Reilly, Shannon M, Saltiel, Alan R, Simon, Joshua, Uhm, Maeran   +7 more
core   +3 more sources

Revisiting cAMP signaling in the carotid body [PDF]

Frontiers in Physiology, 2014
Chronic carotid body (CB) activation is now recognized as being essential in the development of hypertension and promoting insulin resistance; thus, it is imperative to characterize the chemotransduction mechanisms of this organ in order to modulate its activity and improve patient outcomes.
Nunes, Ana R, Holmes, Andrew P, V Conde, Silvia, Gauda, Estelle B, Monteiro, E.C.   +4 more
openaire   +4 more sources

3D‐Printed Piezoionic/Bioelectronic Hydrogel for Electro‐Metabolic Regulation of Osteogenic Differentiation

Advanced Healthcare Materials, EarlyView.
A 3D‐printed piezoionic GPMx hydrogel enables stable electromechanical signal generation under mechanical loading, exhibiting long‐term durability and low fatigue. As a bioactive patch, it restores endogenous bioelectricity to stimulate osteogenesis via Ca2+ influx and mitochondrial activation, while simultaneously enabling label‐free alkaline ...
Sayan Deb Dutta, Myoung Joon Jeon, Youjin Seol, Ki‐Taek Lim   +3 more
wiley   +1 more source

Transfer Functions for Protein Signal Transduction: Application to a Model of Striatal Neural Plasticity [PDF]

, 2013
We present a novel formulation for biochemical reaction networks in the context of signal transduction. The model consists of input-output transfer functions, which are derived from differential equations, using stable equilibria.
C Cepeda, C Li, D Gilbert, E Fernandez, F Erhard, F Theis, Gabriele Scheler, J Deng, J Lagarias, J Srividhya, J Wu, JE Purvis, JH Kotaleski, JJ Hughey, JJ Saucerman, JJ Tyson, M Kim, M Lindskog, M Yger, MI Stefan, MJ Kraeutler, N Le Novere, NH Woo, O Eriksson, P Svenningsson, PE Barbano, Peter Csermely, RC Yu, RF Oliveira, S Bandara, S Maslov, S Maslov, S Pepke, T Manninen, T Nakano, US Bhalla, Z Qi, Z Qi   +37 more
core   +4 more sources

cAMP Signalling Pathway in Biocontrol Fungi

Current Issues in Molecular Biology, 2022
Biocontrol is a complex process, in which a variety of physiological and biochemical characteristics are altered. The cAMP signalling pathway is an important signal transduction pathway in biocontrol fungi and consists of several key components. The G-protein system contains G-protein coupled receptors (GPCRs), heterotrimeric G-proteins, adenylate ...
Zhan-Bin Sun, Shu-Fan Yu, Chu-Lun Wang, Ling Wang   +3 more
openaire   +3 more sources

An Accessible Microfluidic Platform for the Generation of Polarized Brain Organoids

Advanced Materials Technologies, EarlyView.
This study presents an accessible double‐gradient microfluidic device that enables controlled morphogen delivery and spatially polarized differentiation in brain organoids. By integrating a pump‐free design and stable fabrication method, the platform generates dorsal–ventral neuronal asymmetry, offering a reproducible and versatile approach to model ...
Daniel Pérez‐Calixto, Manuel Alejandro Vazquez Valle, Mitzi Pérez‐Calixto, Cindy Peto‐Gutiérrez, Iván Velasco, Genaro Vázquez‐Victorio, Itzel Escobedo‐Avila   +6 more
wiley   +1 more source

Cyclic AMP pathway activation and extracellular zinc induce rapid intracellular zinc mobilization in Candida albicans [PDF]

, 2018
LK was supported by Innovation Fund Denmark, DK (4019-00019B). Pcovery ApS received funding from Wellcome Trust, Research Councils, UK (100480/Z/12), Novo Seeds, DK and Boehringer Ingelheim Venture Fund, D.
Anja T. Fuglsang, Anne-Marie L. Winther, Duncan Wilson, Lasse Kjellerup, Lasse Kjellerup   +4 more
core   +3 more sources

Additive Manufacturing of Patient‐Specific Intracranial Aneurysm Cell Culture Models

Advanced Materials Technologies, EarlyView.
Patient‐specific intracranial aneurysm models were fabricated using chocolate moulding, 3D printed water‐soluble cores, and direct resin 3D printing. Moulding PDMS around sacrificial cores made of chocolate or 3D printed water‐soluble resin yielded accurate, expandable, and endothelializable models that outperformed resin‐based approaches.
Chloe M. de Nys, Jaimee‐Lee Wood, James I. Novak, Danilo Carluccio, Craig D. Winter, Ashley R. Murphy, Mark C. Allenby   +6 more
wiley   +1 more source

Bacillus anthracis edema factor substrate specificity: evidence for new modes of action [PDF]

, 2012
Since the isolation of Bacillus anthracis exotoxins in the 1960s, the detrimental activity of edema factor (EF) was considered as adenylyl cyclase activity only.
Agrawal, Altaweel, Basler, Bauche, Bell, Benson, Beste, Bock, Bond, Boyd, Bradley, Brown, Burhenne, Carbonetti, Carbonetti, Carson-Walter, Casteel, Christensen, Christensen, Confer, Copsel, Crawford, Crowe, Cunningham, Dalkas, Defer, Deuquet, Ding, Drum, Duesbery, Feld, Firoved, Friedlander, Fu, Fukuhara, Gaion, Gille, Gordon, Göttle, Hammerschmidt, He, Helfman, Hong, Ivarsson, Jernigan, Johnson, Katayama, Katayama, Kaupp, Kintzer, Klimpel, Laine, Larabee, Larabee, Leppla, Liu, Martin Göttle, McDonough, Milne, Mogridge, Mogridge, Newton, Newton, Newton, Newton, Newton, Oncu, O´Brien, Park, Petosa, Pezard, Postea, Puhar, Roland Seifert, Santelli, Scobie, Scobie, Scorpio, Shapiro, Shen, Shirshev, Soelaiman, Stefan Dove, Sun, Tamayo, Taylor, Taylor, Tesmer, Thomas, Tournier, Vitale, Vitale, Vojtova, Yeager, Zong   +94 more
core   +2 more sources

At Home Detection of Ovarian Health Biomarker in Menstruation Blood

Advanced Materials Technologies, EarlyView.
A lateral flow assay enables the detection of anti‐Müllerian hormone directly in unprocessed menstrual blood using silica‐gold nanoshells and smartphone‐assisted machine learning analysis. The platform supports decentralized, user‐operated testing in wearable and dipstick formats, highlighting the potential of menstrual blood as a non‐invasive matrix ...
Lucas Dosnon, Thomas Rduch, Salma Sherif Azer, Inge K. Herrmann   +3 more
wiley   +1 more source