Results 91 to 100 of about 1,301,166 (250)

Increased luminescence of the GloSensor cAMP assay in LβT2 cells does not correlate with cAMP accumulation under low pH conditions

The Journal of Reproduction and Development, 2019
Cyclic adenosine monophosphate (cAMP) plays a pivotal role in gonadotrope responses in the pituitary. Gonadotropin-releasing hormone (GnRH) mediated synthesis and secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are regulated ...
Shiori MUSHA, Syo MURAKAMI, Ryotaro KOJIMA, Hideaki TOMURA   +3 more
doaj   +1 more source

cAMP-CREB and NFAT signaling are significantly increased by L441R ZIP14.

, 2018
Luciferase reporter assays investigating cAMP-CREB activity, NF-κB activity and NFAT activity by wildtype (WT), L441R and truncated (W22X) ZIP14 in (A) HEK293T cells and (B) Saos-2 cells demonstrate a significant increase in cAMP-CREB and NFAT signaling ...
Jérôme J. Waterval (5066240), Ineke D. C. Jansen (5066222), Geert J. Behets (630682), Johannes J. Manni (227358), Vere M. Borra (5066231), Tolunay Beker Aydemir (125630), Martin Lammens (190864), Thorsten Schinke (126724), Eveline Boudin (5066225), Wim Van Hul (5066216), Gretl Hendrickx (5066234), Geert Mortier (25729), Christophe Hermans (5066228), Ellen Steenackers (5066219), Niels Kamerling (5066213), Vincent Everts (197636), Timur A. Yorgan (4557115), Christine Plumeyer (5066237), Björn Busse (126702), Robert J. Cousins (125638), Patrick C. D’Haese (700370), Robert J. Stokroos (2625307)   +21 more
core   +1 more source

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

Camp Wolters - Texas

, 1945
Illustrated here is a panoramic view of Camp Wolters, Texas. Labels on photograph identify (left to right) Area No. 4, Sports Arena, Service Club, Area No. 5, Area No. 3, Area No. 2, and Area No.1.
Camp Wolters Studio
core  

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

TRPC6 loss triggers mitochondrial dysfunction that drives white adipose tissue vulnerability to obesity and insulin resistance

Experimental and Molecular Medicine
Calcium signaling is essential for adipocyte function; however, the upstream Ca2+ channels coordinating adipose metabolism remain poorly defined. Here, we identify TRPC6 as a Ca2+ channel enriched in early adipocyte progenitors that orchestrate white ...
Phan Anh Nguyen, Kyu-Hee Hwang, Duyen Thi Thuy Tran, Tae Sic Lee, Kyu-Sang Park, Seung-Kuy Cha   +5 more
doaj   +1 more source

Hypomethylation of GNA15 Promotes Pancreatic Ductal Adenocarcinoma Progression and Macrophage M2 Polarization via STAT3‐CXCL8 Axis

Advanced Science, EarlyView.
A schematic model summarizing GNA15's mechanism in mediating macrophage M2 polarization and Gemcitabine resistance. ABSTRACT The complexity of pancreatic ductal adenocarcinoma (PDAC) progression, coupled with the lack of effective immunotherapy, underscores the imperative to deepen our understanding of its mechanisms and identify suitable immune ...
Weihui Guo, Zhenyuan Qian, Lei Wang, Weilang Xu, Yuxin Weng, Kai Jiang, Zaiyuan Ye, Ji Xu, Guangyuan Song   +8 more
wiley   +1 more source

A C‐Nucleoside Analogue of Cordycepin With High Metabolic Stability and Potent Anti‐Psoriatic Activity via Microneedle Delivery

Advanced Science, EarlyView.
This work identified CPD3a as a potent, stable C‐nucleoside cordycepin derivative. When formulated into microneedle array for topical treatment, it ameliorated psoriasis by rebalancing immunity and enhancing antioxidant defenses. ABSTRACT Psoriasis is a chronic inflammatory disorder characterized by immune dysregulation and epidermal hyperplasia ...
Wenfang Pan, Xinyue Shao, Yuanchen Zhong, Xujie Sun, Lixuan Yin, Zongyan He, Tianqun Lang, Yuanchao Xie   +7 more
wiley   +1 more source

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source