Results 101 to 110 of about 1,301,166 (250)

cAMP-dependent signaling pathways as potential targets for inhibition of Plasmodium falciparum blood stages.

, 2021
We review the role of signaling pathways in regulation of the key processes of merozoite egress and red blood cell invasion by Plasmodium falciparum and, in particular, the importance of the second messengers, cAMP and Ca2+, and cyclic nucleotide ...
Gordon Langsley (85708), Shailja Singh (228856), Anthony A Holder (8155593), Chetan E Chitnis (9092903), Kunal More (10860405), Daniela Bertinetti (226973), Malak Haidar (3691492), Friedrich W Herberg (10973355), Edwin Lasonder (88845), Eileen J Kennedy (10973352)   +9 more
core  

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source

An integrated, cross-regulation pathway model involving activating/adaptive and feed-forward/feed-back loops for directed oscillatory cAMP signal-relay/response during the development of Dictyostelium

Frontiers in Cell and Developmental Biology
Self-organized and excitable signaling activities play important roles in a wide range of cellular functions in eukaryotic and prokaryotic cells. Cells require signaling networks to communicate amongst themselves, but also for response to environmental ...
Pundrik Jaiswal, Netra Pal Meena, Fu-Sheng Chang, Xin-Hua Liao, Lou Kim, Alan R. Kimmel   +5 more
doaj   +1 more source

Regulation of arginase II expression in macrophages by supernatants of apoptotic cells [PDF]

, 2010
Apoptotic cell (AC)-derived factors alter the physiology of macrophages (M Phi s) towards a regulatory phenotype that is characterized by enhanced production of anti-inflammatory mediators, an attenuated pro-inflammatory cytokine profile and reduced ...
Barra, Vera
core  

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Phosphodiesterases 4B and 4D Differentially Regulate cAMP Signaling in Calcium Handling Microdomains of Mouse Hearts

The ubiquitous second messenger 3′,5′-cyclic adenosine monophosphate (cAMP) regulates cardiac excitation-contraction coupling (ECC) by signaling in discrete subcellular microdomains.
Viacheslav O. Nikolaev, Nikoleta Pavlaki, Hariharan Subramanian, Antonio V. Failla, Axel E. Kraft, Nadja I. Bork, Bernd Zobiak, Marco Conti   +7 more
core   +1 more source

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

Famous First Words @ ZSR Library Writers' Camp

ZSR Writers' Camp is an outreach event sponsored by the Z. Smith Reynolds Library at Wake Forest University since 2016. Each Writers' Camp is composed of current Wake Forest students and varies by edition.
ZSR Writers' Camp 2024
core   +1 more source

Specification of spatial relationships in directed graphs of cell signaling networks [PDF]

, 2008
Graph theory provides a useful and powerful tool for the analysis of cellular signaling networks. Intracellular components such as cytoplasmic signaling proteins, transcription factors and genes are connected by links, representing various types of ...
Susana R. Neves, Ravi Iyengar, Azi Lipshtat   +2 more
core  

The Role of Cyclic AMP Signaling in Cardiac Fibrosis

, 2019
Myocardial stress and injury invariably promote remodeling of the cardiac tissue, which is associated with cardiomyocyte death and development of fibrosis. The fibrotic process is initially triggered by the differentiation of resident cardiac fibroblasts
Halima Osman, Simon Kaiser, Dario Diviani, Marion Delaunay   +3 more
core   +1 more source