Results 11 to 20 of about 1,301,166 (250)

Hedgehog and Gpr161: Regulating cAMP Signaling in the Primary Cilium

Cells, 2020
Compartmentalization of diverse types of signaling molecules contributes to the precise coordination of signal propagation. The primary cilium fulfills this function by acting as a spatiotemporally confined sensory signaling platform.
Philipp Tschaikner, Florian Enzler, Omar Torres-Quesada, Pia Aanstad, Eduard Stefan   +4 more
doaj   +2 more sources

Multifaceted Roles of cAMP Signaling in the Repair Process of Spinal Cord Injury and Related Combination Treatments

Frontiers in Molecular Neuroscience, 2022
Spinal cord injury (SCI) results in multiple pathophysiological processes, including blood–spinal cord barrier disruption, hemorrhage/ischemia, oxidative stress, neuroinflammation, scar formation, and demyelination.
Gang Zhou, Zhiyan Wang, Shiyuan Han, Xiaokun Chen, Zhimin Li, Xianghui Hu, Yongning Li, Yongning Li, Jun Gao   +8 more
doaj   +1 more source

cAMP signaling: a remarkably regional affair [PDF]

Trends in Biochemical Sciences
Roshanak Irannejad, John D. Scott, Andreas Bock   +2 more
exaly   +2 more sources

Compartmentalised cAMP signalling in the primary cilium

Frontiers in Physiology, 2023
cAMP is a universal second messenger that relies on precise spatio-temporal regulation to control varied, and often opposing, cellular functions. This is achieved via selective activation of effectors embedded in multiprotein complexes, or signalosomes ...
Ester Paolocci, Manuela Zaccolo
doaj   +1 more source

Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels

Frontiers in Physiology, 2020
Voltage-gated Kv7 potassium channels, encoded by KCNQ genes, have major physiological impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic adenosine monophosphate (cAMP), a well-known intracellular secondary messenger, can
Jennifer van der Horst, Iain A. Greenwood, Thomas A. Jepps   +2 more
doaj   +1 more source

The role of type 4 phosphodiesterases in generating microdomains of cAMP: Large scale stochastic simulations [PDF]

, 2010
Cyclic AMP (cAMP) and its main effector Protein Kinase A (PKA) are critical for several aspects of neuronal function including synaptic plasticity. Specificity of synaptic plasticity requires that cAMP activates PKA in a highly localized manner despite ...
Terrin, A., Terrin, A, Zaccolo Manuela, Rodrigo F Oliveira, Oliveira Rodrigo F., Kim, M., Blackwell, K., Cannon, R.C., Kim T Blackwell, Oliveira, RF, Wonryull Koh, Di Benedetto Giulietta, Kim MyungSook, Giulietta Di Benedetto, Manuela Zaccolo, Zaccolo, M, Cannon, RC, Terrin Anna, MyungSook Kim, Zaccolo, Manuela, Anna Terrin, Robert C Cannon, Di Benedetto, G., Cannon Robert C., Koh, K., Robert C. Cannon, Di Benedetto, G, Koh Wonryull, Zaccolo, M., Koh, W, Blackwell Kim T., Kim T. Blackwell, Rodrigo F. Oliveira, Oliveira, R.F., Kim, M, Blackwell, KT   +35 more
core   +2 more sources

PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome [PDF]

, 2012
Previous work has shown that the protein kinase A (PKA)–regulated phosphodiesterase (PDE) 4D3 binds to A kinase–anchoring proteins (AKAPs). One such protein, AKAP9, localizes to the centrosome.
Stangherlin, A, Surdo, N. C., Terrin, A., Sawa, A., Terrin, A, N. E. Jordanides, A. Stangherlin, Monterisi, S, Mountford, JC, Monterisi, S., A. Terrin, Surdo, NC, Stefania Monterisi, Akira Sawa, Mongillo, M, Jordanides, NE, Alessandra Stangherlin, Koschinski, A, Manuela Zaccolo, Joanne C. Mountford, Nicoletta C. Surdo, Niove E. Jordanides, Jordanides, N..E., Anna Zoccarato, Koschinski, A., Zaccolo, Manuela, MONGILLO, MARCO, Andreas Koschinski, Anna Terrin, M. Zaccolo, Sawa, A, A. Koschinski, A. Zoccarato, Zoccarato, A., Zaccolo, M., A. Sawa, Mountford, J.C., Zoccarato, A, N. C. Surdo, Marco Mongillo, Stangherlin, A., Mongillo, M., S. Monterisi, J. C. Mountford   +43 more
core   +1 more source

cAMP Signals in Drosophila Motor Neurons Are Confined to Single Synaptic Boutons

Cell Reports, 2016
Summary: The second messenger cyclic AMP (cAMP) plays an important role in synaptic plasticity. Although there is evidence for local control of synaptic transmission and plasticity, it is less clear whether a similar spatial confinement of cAMP signaling
Isabella Maiellaro, Martin J. Lohse, Robert J. Kittel, Davide Calebiro   +3 more
doaj   +1 more source

Atherogenic lipid stress induces platelet hyperactivity through CD36-mediated hyposensitivity to prostacyclin: the role of phosphodiesterase 3A

Haematologica, 2020
Prostacyclin (PGI2) controls platelet activation and thrombosis through a cyclic adenosine monophosphate (cAMP) signaling cascade. However, in patients with cardiovascular diseases this protective mechanism fails for reasons that are unclear.
Martin Berger, Zaher Raslan, Ahmed Aburima, Simbarashe Magwenzi, Katie S. Wraith, Benjamin E.J. Spurgeon, Matthew S. Hindle, Robert Law, Maria Febbraio, Khalid M. Naseem   +9 more
doaj   +1 more source

Role of the cAMP signaling pathway in the dissemination and development on pepper fruit anthracnose disease caused by Colletotrichum scovillei

Frontiers in Cellular and Infection Microbiology, 2022
The ascomycete fungus Colletotrichum scovillei causes severe anthracnose disease on the fruit of sweet pepper and chili pepper (Capsicum annuum L.) worldwide. Understanding the biology of C.
Teng Fu, Hyun-Hoo Park, Kyoung Su Kim
doaj   +1 more source