Results 11 to 20 of about 308,089 (303)

cAMP signaling: a remarkably regional affair [PDF]

Trends in Biochemical Sciences
Louis Pasteur once famously said 'in the fields of observation chance favors only the prepared mind'. Much of chance is being in the right place at the right time. This is particularly true in the crowded molecular environment of the cell where being in the right place is often more important than timing.
Andreas Böck, Roshanak Irannejad, John D Scott   +2 more
exaly   +4 more sources

cAMP signaling in subcellular compartments [PDF]

Pharmacology & Therapeutics, 2014
In the complex microcosm of a cell, information security and its faithful transmission are critical for maintaining internal stability. To achieve a coordinated response of all its parts to any stimulus the cell must protect the information received from potentially confounding signals. Physical segregation of the information transmission chain ensures
Konstantinos Lefkimmiatis, Manuela Zaccolo   +1 more
exaly   +5 more sources

The development of compartmentation of cAMP signaling in cardiomyocytes: the role of T-Tubules and caveolae microdomains

Journal of Cardiovascular Development and Disease, 2018
3′-5′-cyclic adenosine monophosphate (cAMP) is a signaling messenger produced in response to the stimulation of cellular receptors, and has a myriad of functional applications depending on the cell type.
Bhogal, NK, Gorelik, J, Hasan, A
core   +3 more sources

Subcellular Organization of the cAMP Signaling Pathway [PDF]

Pharmacological Reviews, 2021
The field of cAMP signaling is witnessing exciting developments with the recognition that cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal coding. This realization has changed our understanding of cAMP signaling from a model in which cAMP connects a receptor at the plasma membrane to an intracellular ...
Manuela Zaccolo, Anna Zerio, Miguel J. Lobo   +2 more
openaire   +2 more sources

Mechanistic insights from animal models of neurofibromatosis type 1 cognitive impairment

Disease Models & Mechanisms, 2022
Neurofibromatosis type 1 (NF1) is an autosomal-dominant neurogenetic disorder caused by mutations in the gene neurofibromin 1 (NF1). NF1 predisposes individuals to a variety of symptoms, including peripheral nerve tumors, brain tumors and cognitive ...
Andrew H. Miller, Mary C. Halloran
doaj   +1 more source

Molecular Targets and Biological Functions of cAMP Signaling in Arabidopsis

Biomolecules, 2021
Cyclic AMP (cAMP) is a pivotal signaling molecule existing in almost all living organisms. However, the mechanism of cAMP signaling in plants remains very poorly understood.
Ruqiang Xu, Yanhui Guo, Song Peng, Jinrui Liu, Panyu Li, Wenjing Jia, Junheng Zhao   +6 more
doaj   +1 more source

Mitochondrial cAMP signaling [PDF]

Cellular and Molecular Life Sciences, 2016
Cyclic adenosine 3, 5'-monophosphate (cAMP) is a ubiquitous second messenger regulating many biological processes, such as cell migration, differentiation, proliferation and apoptosis. cAMP signaling functions not only on the plasma membrane, but also in the nucleus and in organelles such as mitochondria.
Zhang, Fan, Zhang, Liping, Qi, Yun, Xu, Hong   +3 more
openaire   +2 more sources

Early cAMP signaling orchestrates single-cell synchronicity throughout Dictyostelium development. [PDF]

Commun Biol
Synchronicity is observed in many biological systems, including development, as seen in vertebrate body axis formation, fly eye development, and development of the social amoeba D. discoideum.
Katoh-Kurasawa M, Trnovec L, Lehmann P, Chen R, Li Y, Zupan B, Shaulsky G.   +6 more
europepmc   +2 more sources

PDE4-Mediated cAMP Signalling [PDF]

Journal of Cardiovascular Development and Disease, 2018
cAMP is the archetypal and ubiquitous second messenger utilised for the fine control of many cardiovascular cell signalling systems. The ability of cAMP to elicit cell surface receptor-specific responses relies on its compartmentalisation by cAMP hydrolysing enzymes known as phosphodiesterases.
Fertig, Bracy A., Baillie, George S.
openaire   +4 more sources

The cAMP-signaling cancers: Clinically-divergent disorders with a common central pathway

Frontiers in Endocrinology, 2022
The cAMP-signaling cancers, which are defined by functionally-significant somatic mutations in one or more elements of the cAMP signaling pathway, have an unexpectedly wide range of cell origins, clinical manifestations, and potential therapeutic options.
Graeme B. Bolger
doaj   +1 more source