Results 21 to 30 of about 308,089 (303)
cAMP Signaling in Nanodomains [PDF]
Cell, 2020 Cyclic-3',5'-adenosine monophosphate (cAMP) is an ancient second messenger but organizing signaling selectivity on the nanoscale is poorly understood. Examining transport of a new fluorescent cAMP probe, Bock and coworkers observe "buffered diffusion" and establish phosphodiesterase activity can organize cAMP nanodomains, while Zhao and coworkers find ...
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Allosteric linkers in cAMP signalling [PDF]
Biochemical Society Transactions, 2014 Weak interactions mediated by dynamic linkers are key determinants of allosteric regulation in multidomain signalling proteins. However, the mechanisms of linker-dependent control have remained largely elusive. In the present article, we review an allosteric model introduced recently to explain how signalling proteins effectively sense and respond to ...
Madoka, Akimoto +6 more
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cAMP Signaling in Pathobiology of Alcohol Associated Liver Disease
Biomolecules, 2020 The importance of cyclic adenosine monophosphate (cAMP) in cellular responses to extracellular signals is well established. Many years after discovery, our understanding of the intricacy of cAMP signaling has improved dramatically.
Mohamed Elnagdy +3 more
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Frontiers in Molecular Neuroscience, 2022 Spinal cord injury (SCI) results in multiple pathophysiological processes, including blood–spinal cord barrier disruption, hemorrhage/ischemia, oxidative stress, neuroinflammation, scar formation, and demyelination.
Gang Zhou +8 more
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Membranes prime the RapGEF EPAC1 to transduce cAMP signaling. [PDF]
Nat Commun, 2023 EPAC1, a cAMP-activated GEF for Rap GTPases, is a major transducer of cAMP signaling and a therapeutic target in cardiac diseases. The recent discovery that cAMP is compartmentalized in membrane-proximal nanodomains challenged the current model of EPAC1 ...
Sartre C +11 more
europepmc +2 more sources
Compartmentalised cAMP signalling in the primary cilium
Frontiers in Physiology, 2023 cAMP is a universal second messenger that relies on precise spatio-temporal regulation to control varied, and often opposing, cellular functions. This is achieved via selective activation of effectors embedded in multiprotein complexes, or signalosomes ...
Ester Paolocci, Manuela Zaccolo
doaj +1 more source
Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels
Frontiers in Physiology, 2020 Voltage-gated Kv7 potassium channels, encoded by KCNQ genes, have major physiological impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic adenosine monophosphate (cAMP), a well-known intracellular secondary messenger, can
Jennifer van der Horst +2 more
doaj +1 more source
Zinc Inhibition of cAMP Signaling [PDF]
Journal of Biological Chemistry, 2002 Zn(2+) is required as either a catalytic or structural component for a large number of enzymes and thus contributes to a variety of important biological processes. We report here that low micromolar concentrations of Zn(2+) inhibited hormone- or forskolin-stimulated cAMP production in N18TG2 neuroblastoma cells.
Claudette, Klein +4 more
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cAMP Signaling in Leukocyte Transendothelial Migration [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2007 The migration of leukocytes across the vascular endothelium is crucial for immunosurveillance as well as for inflammatory responses. Uncontrolled leukocyte transendothelial migration results in pathologies such as asthma, rheumatoid arthritis, and atherosclerosis.
Lorenowicz, Magdalena J. +2 more
openaire +3 more sources
Compartmentalized PDE4A5 signaling impairs hippocampal synaptic plasticity and long-term memory [PDF]
, 2016 Alterations in cAMP signaling are thought to contribute to neurocognitive and neuropsychiatric disorders. Members of the cAMP-specific phosphodiesterase 4 (PDE4) family, which contains >25 different isoforms, play a key role in determining spatial ...
Abel, Ted +13 more
core +5 more sources