Results 1 to 10 of about 2,636 (125)

Molecular evolution of a-kinase anchoring protein (AKAP)-7: implications in comparative PKA compartmentalization [PDF]

BMC Evolutionary Biology, 2012
Background A-Kinase Anchoring Proteins (AKAPs) are molecular scaffolding proteins mediating the assembly of multi-protein complexes containing cAMP-dependent protein kinase A (PKA), directing the kinase in discrete subcellular locations.
Johnson Keven R, Nicodemus-Johnson Jessie, Carnegie Graeme K, Danziger Robert S   +3 more
doaj   +2 more sources

Biophysical and aerodynamic properties of a peptide targeting the A-kinase anchoring function of PI3Kγ for pulmonary cAMP modulation [PDF]

Scientific Reports
Cyclic AMP (cAMP) signaling specificity relies on precise spatial regulation mediated by A-kinase anchoring proteins (AKAPs), which localize protein kinase A (PKA) within defined microdomains.
Angela Della Sala, Valentina Sala, Cosmin Stefan Butnarasu, Laura Tasca, Gabriella Costabile, Marco Mergiotti, Andrea Gramegna, Francesco Blasi, Stefano Aliberti, Francesca Ungaro, Sonja Visentin, Emilio Hirsch, Alessandra Ghigo   +12 more
doaj   +2 more sources

Targeting PI3Kγ anchoring enhances CFTR membrane localization and modulator efficacy via PKD1 [PDF]

JCI Insight
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes a cAMP-activated chloride channel, cause cystic fibrosis (CF), the most common life-threatening inherited disorder among White individuals.
Alessandra Murabito, Marco Mergiotti, Valeria Capurro, Alessia Loffreda, Mingchuan Li, Paola Peretto, Kai Ren, Andrea Raimondi, Carlo Tacchetti, Dario Diviani, Nicoletta Pedemonte, Emilio Hirsch, Alessandra Ghigo   +12 more
doaj   +2 more sources

A-Kinase Anchoring Protein-Lbc: A Molecular Scaffold Involved in Cardiac Protection

Journal of Cardiovascular Development and Disease, 2018
Heart failure is a lethal disease that can develop after myocardial infarction, hypertension, or anticancer therapy. In the damaged heart, loss of function is mainly due to cardiomyocyte death and associated cardiac remodeling and fibrosis.
Dario Diviani, Halima Osman, Erica Reggi
doaj   +3 more sources

N3A motifs in RIβ mediate allosteric crosstalk between cAMP and ATP in PKA activation. [PDF]

Protein Sci
Abstract The RIβ subunit of cAMP‐dependent protein kinase (PKA) is highly expressed in the brain, yet it remains the least studied of the PKA regulatory subunits (R). As pathologic variants of its gene are increasingly implicated in neurodevelopmental disorders, neurodegeneration, and cancer, gaining more information about the structure/function of RIβ,
Wu J, Bruystens JGH, Sahoo P, Bubis J, Maillard RA, Taylor SS, Ilouz R.   +6 more
europepmc   +2 more sources

Smoothened and ciliary GPCRs regulate ciliary protein kinase A activity involved in Hedgehog signal transduction. [PDF]

PLoS Biology
Hedgehog (HH) signaling in vertebrates is dependent on the primary cilium, an organelle that scaffolds signal transduction. HH signals induce ciliary enrichment of Smoothened (SMO) and ciliary departure of the G protein-coupled receptor (GPCR) GPR161 to ...
Thi D Nguyen, Mia J Konjikusic, Lorenzo M Del Castillo, Roshanak Irannejad, Jeremy F Reiter   +4 more
doaj   +2 more sources

The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3β Interaction Protein (GSKIP) Regulates β-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3β. [PDF]

J Biol Chem, 2016
Dema A, Schröter MF, Perets E, Skroblin P, Moutty MC, Deàk VA, Birchmeier W, Klussmann E.   +7 more
europepmc   +2 more sources

Defining A-Kinase Anchoring Protein (AKAP) Specificity for the Protein Kinase A Subunit RI (PKA-RI). [PDF]

Chembiochem, 2016
Autenrieth K, Bendzunas NG, Bertinetti D, Herberg FW, Kennedy EJ.   +4 more
europepmc   +2 more sources

Carboplatin Enhances the Activity of Human Transient Receptor Potential Ankyrin 1 through the Cyclic AMP-Protein Kinase A-A-Kinase Anchoring Protein (AKAP) Pathways. [PDF]

Int J Mol Sci, 2019
Miyano K, Shiraishi S, Minami K, Sudo Y, Suzuki M, Yokoyama T, Terawaki K, Nonaka M, Murata H, Higami Y, Uezono Y.   +10 more
europepmc   +2 more sources

Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection. [PDF]

J Biol Chem, 2013
Gold MG, Fowler DM, Means CK, Pawson CT, Stephany JJ, Langeberg LK, Fields S, Scott JD.   +7 more
europepmc   +2 more sources