Results 21 to 30 of about 3,121 (209)

Exploring AKAPs in visual signaling [PDF]

Frontiers in Molecular Neuroscience
The complex nature of the retina demands well-organized signaling to uphold signal accuracy and avoid interference, a critical aspect in handling a variety of visual stimuli.
Julia Tomczak, Joanna Mackiewicz, Malwina Lisek, Aleksandra Kaluza, Tomasz Boczek   +4 more
doaj   +2 more sources

Polymorphisms/Mutations in A-Kinase Anchoring Proteins (AKAPs): Role in the Cardiovascular System [PDF]

Journal of Cardiovascular Development and Disease, 2018
A-kinase anchoring proteins (AKAPs) belong to a family of scaffolding proteins that bind to protein kinase A (PKA) by definition and a variety of crucial proteins, including kinases, phosphatases, and phosphodiesterases. By scaffolding these proteins together, AKAPs build a “signalosome” at specific subcellular locations and compartmentalize PKA ...
Santosh Suryavanshi, Shweta Jadhav, Bradley K. McConnell   +2 more
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Organizing signal transduction through A‐kinase anchoring proteins (AKAPs) [PDF]

The FEBS Journal, 2010
A fundamental role for protein–protein interactions in the organization of signal transduction pathways is evident. Anchoring, scaffolding and adapter proteins function to enhance the precision and directionality of these signaling events by bringing enzymes together. The cAMP signaling pathway is organized by A‐kinase anchoring proteins.
Jeremy S. Logue, John D. Scott
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Compartmentalization Role of A-Kinase Anchoring Proteins (AKAPs) in Mediating Protein Kinase A (PKA) Signaling and Cardiomyocyte Hypertrophy [PDF]

International Journal of Molecular Sciences, 2014
The Beta-adrenergic receptors (β-ARs) stimulation enhances contractility through protein kinase-A (PKA) substrate phosphorylation. This PKA signaling is conferred in part by PKA binding to A-kinase anchoring proteins (AKAPs). AKAPs coordinate multi-protein signaling networks that are targeted to specific intracellular locations, resulting in the ...
Abeer Rababa’h, Sonal Singh, Santosh Suryavanshi, Salah E. Altarabsheh, Salil V. Deo, Bradley K. McConnell   +5 more
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Cloning and Characterization of a Protein Kinase A Anchoring Protein (AKAP)-related Protein That Interacts with and Regulates Sphingosine Kinase 1 Activity [PDF]

Journal of Biological Chemistry, 2002
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that has novel dual actions. S1P is the ligand for a family of G protein-coupled receptors known as S1PRs that mediate various physiological functions. Growth factors rapidly activate sphingosine kinase type 1 (SPHK1) resulting in phosphorylation of sphingosine to form S1P, which ...
Emanuela Lacaná, Michael Maceyka, Sheldon Milstien, Sarah Spiegel   +3 more
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Mutational Analysis of the A-Kinase Anchoring Protein (AKAP)-binding Site on RII [PDF]

Journal of Biological Chemistry, 1996
Compartmentalization of the type II cAMP-dependent protein kinase is conferred by interaction of the regulatory subunit (RII) with A-Kinase Anchoring Proteins (AKAPs). The AKAP-binding site involves amino-terminal residues on each RII protomer and is formed through dimerization.
Zachary E. Hausken, Mark L. Dell’Acqua, Vincent M. Coghlan, John D. Scott   +3 more
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Flagellar Radial Spoke Protein 3 Is an a-Kinase Anchoring Protein (Akap) [PDF]

The Journal of Cell Biology, 2001
Previous physiological and pharmacological experiments have demonstrated that the Chlamydomonas flagellar axoneme contains a cAMP-dependent protein kinase (PKA) that regulates axonemal motility and dynein activity. However, the mechanism for anchoring PKA in the axoneme is unknown.
Anne Gaillard, Dennis R. Diener, Joel L. Rosenbaum, Winfield S. Sale   +3 more
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N3A motifs in RIβ mediate allosteric crosstalk between cAMP and ATP in PKA activation. [PDF]

Protein Sci
Abstract The RIβ subunit of cAMP‐dependent protein kinase (PKA) is highly expressed in the brain, yet it remains the least studied of the PKA regulatory subunits (R). As pathologic variants of its gene are increasingly implicated in neurodevelopmental disorders, neurodegeneration, and cancer, gaining more information about the structure/function of RIβ,
Wu J, Bruystens JGH, Sahoo P, Bubis J, Maillard RA, Taylor SS, Ilouz R.   +6 more
europepmc   +2 more sources

Dual Specificity A-kinase Anchoring Proteins (AKAPs) Contain an Additional Binding Region That Enhances Targeting of Protein Kinase A Type I [PDF]

Journal of Biological Chemistry, 2008
A-kinase anchoring proteins (AKAPs) target protein kinase A (PKA) to a variety of subcellular locations. Conventional AKAPs contain a 14-18-amino acid sequence that forms an amphipathic helix that binds with high affinity to the regulatory (R) subunit of PKA type II.
Elisabeth Jarnæss, Anja Ruppelt, Anne Jorunn Stokka, Birgitte Lygren, John D. Scott, Kjetil Taskén   +5 more
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Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79.

Journal of Biological Chemistry, 1992
Postsynaptic densities (PSD) are a network of proteins located on the internal surface of excitatory synapses just inside the postsynaptic membrane. Enzymes associated with the PSD are optimally positioned to respond to signals transduced across the postsynaptic membrane resulting from excitatory synaptic transmission or neurotransmitter release.
Daniel W. Carr, R.E. Stofko-Hahn, Iain D. C. Fraser, Roger D. Cone, J.D. Scott   +4 more
openalex   +3 more sources