, 2007 Kinase anchoring proteins (AKAPs) are a family of structurally diverse multidomain proteins classified solely by their ability to bind cAMP-dependent protein kinase/protein kinase A (PKA).
Alison Jane Davis (7656008)
core +6 more sources
Protein kinase A activity and anchoring are required for ovarian cancer cell migration and invasion. [PDF]
PLoS ONE, 2011 Epithelial ovarian cancer (EOC) is the deadliest of the gynecological malignancies, due in part to its clinically occult metastasis. Therefore, understanding the mechanisms governing EOC dissemination and invasion may provide new targets for ...
Andrew J McKenzie +2 more
doaj +1 more source
Role of a-kinase anchoring proteins (AKAPs) in reproduction [PDF]
Frontiers in Bioscience, 2011 Rapid spatio-temporal organized intracellular signaling is a pivotal mechanism for regulation of functions in many cells, in particular in the female and male gametes, in which functional regulation through rapid increases in protein content is not possible since the mechanisms of transcription/translation are somehow frozen due to meiosis block or DNA
LUCONI, MICHAELA +3 more
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Organizing signal transduction through A‐kinase anchoring proteins (AKAPs) [PDF]
The FEBS Journal, 2010 A fundamental role for protein–protein interactions in the organization of signal transduction pathways is evident. Anchoring, scaffolding and adapter proteins function to enhance the precision and directionality of these signaling events by bringing enzymes together. The cAMP signaling pathway is organized by A‐kinase anchoring proteins.
Jeremy S, Logue, John D, Scott
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Mutational Analysis of the A-Kinase Anchoring Protein (AKAP)-binding Site on RII [PDF]
Journal of Biological Chemistry, 1996 Compartmentalization of the type II cAMP-dependent protein kinase is conferred by interaction of the regulatory subunit (RII) with A-Kinase Anchoring Proteins (AKAPs). The AKAP-binding site involves amino-terminal residues on each RII protomer and is formed through dimerization.
Zachary E. Hausken +3 more
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Flagellar Radial Spoke Protein 3 Is an a-Kinase Anchoring Protein (Akap) [PDF]
The Journal of Cell Biology, 2001 Previous physiological and pharmacological experiments have demonstrated that the Chlamydomonas flagellar axoneme contains a cAMP-dependent protein kinase (PKA) that regulates axonemal motility and dynein activity. However, the mechanism for anchoring PKA in the axoneme is unknown.
A R, Gaillard +3 more
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Polymorphisms/Mutations in A-Kinase Anchoring Proteins (AKAPs): Role in the Cardiovascular System [PDF]
Journal of Cardiovascular Development and Disease, 2018 A-kinase anchoring proteins (AKAPs) belong to a family of scaffolding proteins that bind to protein kinase A (PKA) by definition and a variety of crucial proteins, including kinases, phosphatases, and phosphodiesterases. By scaffolding these proteins together, AKAPs build a “signalosome” at specific subcellular locations and compartmentalize PKA ...
Santosh Suryavanshi +2 more
openaire +3 more sources
Src homology 2 domain-containing phosphatase 2 (Shp2) is a component of the A-kinase-anchoring protein (AKAP)-Lbc complex and is inhibited by protein kinase A (PKA) under pathological hypertrophic conditions in the heart. [PDF]
J Biol Chem, 2012 Burmeister BT +3 more
europepmc +2 more sources
PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome [PDF]
, 2012 Previous work has shown that the protein kinase A (PKA)–regulated phosphodiesterase (PDE) 4D3 binds to A kinase–anchoring proteins (AKAPs). One such protein, AKAP9, localizes to the centrosome.
Stangherlin, A +43 more
core +1 more source
Compartmentalization Role of A-Kinase Anchoring Proteins (AKAPs) in Mediating Protein Kinase A (PKA) Signaling and Cardiomyocyte Hypertrophy [PDF]
International Journal of Molecular Sciences, 2014 The Beta-adrenergic receptors (β-ARs) stimulation enhances contractility through protein kinase-A (PKA) substrate phosphorylation. This PKA signaling is conferred in part by PKA binding to A-kinase anchoring proteins (AKAPs). AKAPs coordinate multi-protein signaling networks that are targeted to specific intracellular locations, resulting in the ...
Abeer Rababa'h +5 more
openaire +2 more sources