Results 31 to 40 of about 3,121 (209)

AKAPs (A-kinase anchoring proteins) and molecules that compose their G-protein-coupled receptor signalling complexes [PDF]

Biochemical Journal, 2004
Cell signalling mediated via GPCRs (G-protein-coupled receptors) is a major paradigm in biology, involving the assembly of receptors, G-proteins, effectors and downstream elements into complexes that approach in design ‘solid-state’ signalling devices.
Craig C. Malbon, Jiangchuan Tao, Hsien‐yu Wang   +2 more
openalex   +4 more sources

Novel insight into the role of A-kinase anchoring proteins (AKAPs) in ischemic stroke and therapeutic potentials

Biomedicine & Pharmacotherapy
Ischemic stroke, a devastating disease associated with high mortality and disability worldwide, has emerged as an urgent public health issue. A-kinase anchoring proteins (AKAPs) are a group of signal-organizing molecules that compartmentalize and anchor a wide range of receptors and effector proteins and have a major role in stabilizing mitochondrial ...
Ziyu He, Letian Xie, Jiyong Liu, Xuan Wei, Wenli Zhang, Zhigang Mei   +5 more
openalex   +3 more sources

Cytoplasmic Anchoring of cAMP-Dependent Protein Kinase (PKA) by A-Kinase Anchor Proteins (AKAPs) Is Required for Meiotic Arrest of Porcine Full-Grown and Growing Oocytes1 [PDF]

Biology of Reproduction, 2014
Mammalian growing oocytes (GOs) lack the ability to resume meiosis, although the molecular mechanism of this limitation is not fully understood. We previously hypothesized that the meiotic incompetence of porcine GOs was attributed to complex spatial-temporal regulation of cAMP-dependent protein kinase (PKA) by A-kinase anchor proteins (AKAPs), but ...
Takanori Nishimura, Wataru Fujii, Koji Sugiura, Kunihiko Naito   +3 more
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A-kinase anchoring in dendritic cells is required for antigen presentation. [PDF]

PLoS ONE, 2009
BACKGROUND: Dendritic cells (DC) are the most potent antigen presenting cells (APC) of the immune system. Prostaglandin E(2), cyclic AMP, and protein kinase A (PKA) have all been shown to regulate DC maturation and activity.
Robynn V Schillace, Casey L Miller, Neal Pisenti, Jeff E Grotzke, Gwendolyn M Swarbrick, David M Lewinsohn, Daniel W Carr   +6 more
doaj   +1 more source

A-kinase anchoring protein 79/150 coordinates α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor sensitization in sensory neurons

Molecular Pain, 2023
Changes in sensory afferent activity contribute to the transition from acute to chronic pain. However, it is unlikely that a single sensory receptor is entirely responsible for persistent pain.
Yan Zhang, Nathaniel A Jeske
doaj   +1 more source

A-Kinase Anchoring Protein 2 Promotes Protection against Myocardial Infarction

Cells, 2021
Myocardial infarction (MI) is a leading cause of maladaptive cardiac remodeling and heart failure. In the damaged heart, loss of function is mainly due to cardiomyocyte death and remodeling of the cardiac tissue.
Darko Maric, Aleksandra Paterek, Marion Delaunay, Irene Pérez López, Miroslav Arambasic, Dario Diviani   +5 more
doaj   +1 more source

Protein kinase A activity and anchoring are required for ovarian cancer cell migration and invasion. [PDF]

PLoS ONE, 2011
Epithelial ovarian cancer (EOC) is the deadliest of the gynecological malignancies, due in part to its clinically occult metastasis. Therefore, understanding the mechanisms governing EOC dissemination and invasion may provide new targets for ...
Andrew J McKenzie, Shirley L Campbell, Alan K Howe   +2 more
doaj   +1 more source

Role for A Kinase-anchoring Proteins (AKAPS) in Glutamate Receptor Trafficking and Long Term Synaptic Depression [PDF]

Journal of Biological Chemistry, 2005
Expression of N-methyl d-aspartate (NMDA) receptor-dependent homosynaptic long term depression at synapses in the hippocampus and neocortex requires the persistent dephosphorylation of postsynaptic protein kinase A substrates. An attractive mechanism for expression of long term depression is the loss of surface AMPA (alpha-amino-3-hydroxy-5 ...
Eric M. Snyder, Marcie Colledge, Robert A. Crozier, Wendy S. Chen, John D. Scott, Mark F. Bear   +5 more
openalex   +4 more sources

A Novel A-Kinase-Anchoring Protein 9 Variant in Premature Coronary Artery Disease: A Case Series. [PDF]

Mol Genet Genomic Med
AKAP9 Q2136E mutation disrupts AKAP9–PRKAR2A interaction and may contribute to early‐onset CAD. ABSTRACT Background Familial premature coronary artery disease (CAD) is often associated with genetic variants. This study investigated potential causal variants in a Chinese pedigree with premature CAD. Methods In total, nine family members were included in
Jiao Y, Wang M, Qiang G, Zhao L, Xi Z, Yu Y, Yin C, Song G.   +7 more
europepmc   +2 more sources

AKAP-Lbc Anchors Protein Kinase A and Nucleates Gα12-selective Rho-mediated Stress Fiber Formation [PDF]

Journal of Biological Chemistry, 2001
Guanine nucleotide exchange factors of the Dbl family relay signals from membrane receptors to Rho family GTPases. We now demonstrate that a longer transcript of the Lbc gene encodes a chimeric molecule, which we have called AKAP-Lbc, that functions as an A-kinase-anchoring protein (AKAP) and a Rho-selective guanine nucleotide exchange factor ...
Dario Diviani, Jacquelyn A. Soderling, John D. Scott   +2 more
openalex   +4 more sources