Results 51 to 60 of about 115,266,211 (193)

Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2) [PDF]

Proceedings of the National Academy of Sciences, 2003
Like other guanine nucleotide-exchange proteins (GEPs) that activate ADP-ribosylation factor (ARF) GTPases, brefeldin A-inhibited GEP2, BIG2, contains an ≈200-aa Sec7 domain that is responsible for this catalytic activity and its inhibition by brefeldin A.
Hewang, Li, Ronald, Adamik, Gustavo, Pacheco-Rodriguez, Joel, Moss, Martha, Vaughan   +4 more
openaire   +2 more sources

A systematic evaluation of protein kinase a-a-kinase anchoring protein interaction motifs [PDF]

, 2015
Protein kinase A (PKA) in vertebrates is localized to specific locations in the cell via A-kinase anchoring proteins (AKAPs). The regulatory subunits of the four PKA isoforms (RIα, RIβ, RIIα, and RIIβ) each form a homodimer, and their dimerization domain
Scholten, Arjen, Heck, Albert J R, Arjen Scholten, Marcel A. G. van der Heyden, Molecular Pharmacy, Pepijn P. Burgers, Bart Kok, Sub Biomol.Mass Spectrometry & Proteom., van der Heyden, MAG, Biomolecular Mass Spectrometry and Proteomics, Sub Biomol.Mass Spect. and Proteomics, Albert J. R. Heck, Burgers, Pepijn P, Kok, Bart, van der Heyden, Marcel A G   +14 more
core   +3 more sources

Subcellular drug targeting illuminates local kinase action

eLife, 2019
Deciphering how signaling enzymes operate within discrete microenvironments is fundamental to understanding biological processes. A-kinase anchoring proteins (AKAPs) restrict the range of action of protein kinases within intracellular compartments.
Paula J Bucko, Chloe K Lombard, Lindsay Rathbun, Irvin Garcia, Akansha Bhat, Linda Wordeman, F Donelson Smith, Dustin J Maly, Heidi Hehnly, John D Scott   +9 more
doaj   +1 more source

Cryopreservation Disrupts TRIM21‐Mediated AKAP3 Ubiquitination and Triggers Stress Granule Formation in Human Sperm

Andrology, EarlyView.
ABSTRACT Background Sperm cryopreservation causes cryodamage, but the roles of posttranslational modifications (PTMs) and stress granules (SGs) in this process remain unclear. Objectives To investigate the molecular mechanism of cryodamage via the TRIM21–AKAP3 axis, PTMs, and SGs.
Yan Wang, Huizhong Xu, Wenhong Lu, Yinghao Wang, Jin Ma, Chengyao Ma, Xiangming Yan, Longlong Fu, Haitao Lv, Ying Liu   +9 more
wiley   +1 more source

Disruptors of AKAP-Dependent Protein–Protein Interactions

, 2022
A-kinase anchoring proteins (AKAPs) are a family of multivalent scaffolding proteins. They engage in direct protein-protein interactions with protein kinases, kinase substrates and further signaling molecules.
Diecke, S., Jens Peter von Kries, Oder, A., Andreas Oder, von Kries, J.P., Martin Neuenschwander, Tamara Pallien, Klussmann, E., Ryan Walker-Gray, Sebastian Diecke, Duncan C. Miller, Enno Klussmann, Miller, D.C., Pallien, T., Neuenschwander, M., Walker-Gray, R.   +15 more
core   +1 more source

Decreased AKAP4/PKA signaling pathway in high DFI sperm affects sperm capacitation

Asian Journal of Andrology
The sperm DNA fragmentation index (DFI) is a metric used to assess DNA fragmentation within sperm. During in vitro fertilization-embryo transfer (IVF-ET), high sperm DFI can lead to a low fertilization rate, poor embryo development, early miscarriage ...
Kun Zhang, Xiu-Hua Xu, Jian Wu, Ning Wang, Gang Li, Gui-Min Hao, Jin-Feng Cao   +6 more
doaj   +1 more source

Sperm protein 17 is expressed in the sperm fibrous sheath

Journal of Translational Medicine, 2009
Background Sperm protein 17 (Sp17) is a highly conserved mammalian protein characterized in rabbit, mouse, monkey, baboon, macaque, human testis and spermatozoa. mRNA encoding Sp17 has been detected in a range of murine and human somatic tissues.
Albani Elena, Franceschini Barbara, Grizzi Fabio, Costa Francesco, Donetti Elena, Gagliano Nicoletta, Chiriva-Internati Maurizio, Levi-Setti Paolo E, Gioia Magda, Jenkins Marjorie, Cobos Everardo, Kast W Martin   +11 more
doaj   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Protein kinase A (PKA) phosphorylation of Shp2 inhibits its phosphatase activity and modulates ligand specificity. [PDF]

, 2015
Pathological cardiac hypertrophy (an increase in cardiac mass resulting from stress-induced cardiac myocyte growth) is a major factor underlying heart failure.
O'Bryan, JP, Burmeister, BT, Wang, L, Gold, MG, Carnegie, GK, Skidgel, RA   +5 more
core  

Roles of A-Kinase Anchoring Proteins and Phosphodiesterases in the Cardiovascular System

Journal of Cardiovascular Development and Disease, 2018
A-kinase anchoring proteins (AKAPs) and cyclic nucleotide phosphodiesterases (PDEs) are essential enzymes in the cyclic adenosine 3’-5’ monophosphate (cAMP) signaling cascade.
Maria Ercu, Enno Klussmann
doaj   +1 more source