Results 51 to 60 of about 3,121 (209)

PKA, PKC, and AKAP localization in and around the neuromuscular junction

BMC Neuroscience, 2001
Background One mechanism that directs the action of the second messengers, cAMP and diacylglycerol, is the compartmentalization of protein kinase A (PKA) and protein kinase C (PKC). A-kinase anchoring proteins (AKAPs) can recruit both enzymes to specific
Newton Alexandra, Smith Donelson, Violin Jonathan D, Barraclough David M, Deerinck Thomas J, Martone Maryann, Yao Virginia J, Humphries Kenneth, Huang Lily, Wang Lin, Perkins Guy A, Scott John D, Taylor Susan S, Ellisman Mark H   +13 more
doaj   +1 more source

A systematic evaluation of protein kinase a-a-kinase anchoring protein interaction motifs [PDF]

, 2015
Protein kinase A (PKA) in vertebrates is localized to specific locations in the cell via A-kinase anchoring proteins (AKAPs). The regulatory subunits of the four PKA isoforms (RIα, RIβ, RIIα, and RIIβ) each form a homodimer, and their dimerization domain
Scholten, Arjen, Heck, Albert J R, Arjen Scholten, Marcel A. G. van der Heyden, Molecular Pharmacy, Pepijn P. Burgers, Bart Kok, Sub Biomol.Mass Spectrometry & Proteom., van der Heyden, MAG, Biomolecular Mass Spectrometry and Proteomics, Sub Biomol.Mass Spect. and Proteomics, Albert J. R. Heck, Burgers, Pepijn P, Kok, Bart, van der Heyden, Marcel A G   +14 more
core   +1 more source

Spoonbill positively regulates JNK signalling mediated apoptosis in Drosophila melanogaster

European Journal of Cell Biology, 2023
A-kinase anchoring protein (AKAP) comprises a family of scaffold proteins, which decides the subcellular localisation of a combination of signalling molecules. Spoonbill (Spoon) is a putative A-kinase anchoring protein in Drosophila.
Rituparna Das, Pranjali Pandey, Bhawana Maurya, Priyadarshika Pradhan, Devanjan Sinha, Ashim Mukherjee, Mousumi Mutsuddi   +6 more
doaj   +1 more source

Caractérisation de la protéine AKAP (A-Kinase Anchoring Protein) chez Plasmodium falciparum

, 2014
Le paludisme est une maladie tropicale due au parasite P. falciparum. Avec le grand nombre de victimes qui lui sont imputées chaque année, cette maladie demeure la plus grande parasitose tropicale et il est primordial de la combattre. Ce combat passe aussi bien par la sensibilisation des populations que par la recherche. Plusieurs échecs thérapeutiques,
Kossiwa Efoala-Bola Bandje
  +5 more sources

Therapeutic strategies for anchored kinases and phosphatases: exploiting short linear motifs and intrinsic disorder

Frontiers in Pharmacology, 2015
Phosphorylation events that occur in response to the second messenger cAMP are controlled spatially and temporally by protein kinase A (PKA) interacting with A-kinase anchoring proteins (AKAPs).
Patrick J Nygren, Patrick J Nygren, John D. Scott, John D. Scott   +3 more
doaj   +1 more source

A-Kinase Anchoring Proteins Diminish TGF-β₁/Cigarette Smoke-Induced Epithelial-To-Mesenchymal Transition

Cells, 2020
Epithelial-to-mesenchymal transition (EMT) plays a role in chronic obstructive pulmonary diseases (COPD). Cyclic adenosine monophosphate (cAMP) can inhibit transforming growth factor-β1 (TGF-β1) mediated EMT. Although compartmentalization via A-
Haoxiao Zuo, Marina Trombetta-Lima, Irene H. Heijink, Christina H. T. J. van der Veen, Laura Hesse, Klaas Nico Faber, Wilfred J. Poppinga, Harm Maarsingh, Viacheslav O. Nikolaev, Martina Schmidt   +9 more
doaj   +1 more source

The Stapled AKAP Disruptor Peptide STAD-2 Displays Antimalarial Activity through a PKA-Independent Mechanism. [PDF]

PLoS ONE, 2015
Drug resistance poses a significant threat to ongoing malaria control efforts. Coupled with lack of a malaria vaccine, there is an urgent need for the development of new antimalarials with novel mechanisms of action and low susceptibility to parasite ...
Briana R Flaherty, Yuxiao Wang, Edward C Trope, Tienhuei G Ho, Vasant Muralidharan, Eileen J Kennedy, David S Peterson   +6 more
doaj   +1 more source

AKAP6 and phospholamban colocalize and interact in HEK‐293T cells and primary murine cardiomyocytes

Physiological Reports, 2019
Phospholamban (PLN) is an important Ca2+ modulator at the sarcoplasmic reticulum (SR) of striated muscles. It physically interacts and inhibits sarcoplasmic reticulum Ca2+ ATPase (SERCA2) function, whereas a protein kinase A (PKA)‐dependent ...
Farigol Hakem Zadeh, Allen C. T. Teng, Uros Kuzmanov, Paige J. Chambers, Allan R. Tupling, Anthony O. Gramolini   +5 more
doaj   +1 more source

Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2) [PDF]

Proceedings of the National Academy of Sciences, 2003
Like other guanine nucleotide-exchange proteins (GEPs) that activate ADP-ribosylation factor (ARF) GTPases, brefeldin A-inhibited GEP2, BIG2, contains an ≈200-aa Sec7 domain that is responsible for this catalytic activity and its inhibition by brefeldin A.
Hewang, Li, Ronald, Adamik, Gustavo, Pacheco-Rodriguez, Joel, Moss, Martha, Vaughan   +4 more
openaire   +2 more sources

Sperm protein 17 is expressed in the sperm fibrous sheath

Journal of Translational Medicine, 2009
Background Sperm protein 17 (Sp17) is a highly conserved mammalian protein characterized in rabbit, mouse, monkey, baboon, macaque, human testis and spermatozoa. mRNA encoding Sp17 has been detected in a range of murine and human somatic tissues.
Albani Elena, Franceschini Barbara, Grizzi Fabio, Costa Francesco, Donetti Elena, Gagliano Nicoletta, Chiriva-Internati Maurizio, Levi-Setti Paolo E, Gioia Magda, Jenkins Marjorie, Cobos Everardo, Kast W Martin   +11 more
doaj   +1 more source