Results 61 to 70 of about 115,266,211 (193)

Retinoid-induced expression and activity of an immediate early tumor suppressor gene in vascular smooth muscle cells. [PDF]

PLoS ONE, 2011
Retinoids are used clinically to treat a number of hyper-proliferative disorders and have been shown in experimental animals to attenuate vascular occlusive diseases, presumably through nuclear receptors bound to retinoic acid response elements (RARE ...
Jeffrey W Streb, Xiaochun Long, Ting-Hein Lee, Qiang Sun, Chad M Kitchen, Mary A Georger, Orazio J Slivano, William S Blaner, Daniel W Carr, Irwin H Gelman, Joseph M Miano   +10 more
doaj   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Phosphoinositide-dependent protein kinase-1 (PDK1)-independent activation of the protein kinase C substrate, protein kinase D [PDF]

, 2007
Phosphoinoisitide dependent kinase l (PDK1) is proposed to phosphorylate a key threonine residue within the catalytic domain of the protein kinase C (PKC) superfamily that controls the stability and catalytic competence of these kinases.
Kelly, April P., Cantrell, Doreen A., Wood, C. David, Matthews, Sharon A.   +3 more
core   +1 more source

The Role of Cyclic AMP Signaling in Cardiac Fibrosis

Cells, 2019
Myocardial stress and injury invariably promote remodeling of the cardiac tissue, which is associated with cardiomyocyte death and development of fibrosis. The fibrotic process is initially triggered by the differentiation of resident cardiac fibroblasts
Marion Delaunay, Halima Osman, Simon Kaiser, Dario Diviani   +3 more
doaj   +1 more source

Dual Specificity A-kinase Anchoring Proteins (AKAPs) Contain an Additional Binding Region That Enhances Targeting of Protein Kinase A Type I [PDF]

Journal of Biological Chemistry, 2008
A-kinase anchoring proteins (AKAPs) target protein kinase A (PKA) to a variety of subcellular locations. Conventional AKAPs contain a 14-18-amino acid sequence that forms an amphipathic helix that binds with high affinity to the regulatory (R) subunit of PKA type II.
Elisabeth, Jarnaess, Anja, Ruppelt, Anne Jorunn, Stokka, Birgitte, Lygren, John D, Scott, Kjetil, Taskén   +5 more
openaire   +2 more sources

Phosphodiesterase 4 cAMP phosphodiesterases as targets for novel anti-inflammatory therapeutics

Allergology International, 2004
Cyclic nucleotides are powerful signaling molecules and their sole means of removal is through the action of cyclic nucleotide phosphodiesterases (PDEs). Elevating levels of cAMP is beneficial in many diseases, including neurological conditions, cancers,
Simon J MacKenzie
doaj   +1 more source

CaV1.2 dynamics in native male arterial myocytes

The Journal of Physiology, Volume 604, Issue 15, Page 6302-6323, 1 August 2026.
Abstract figure legend Proposed model of microtubule‐dependent CaV1.2 reorganization in vascular disease. Schematic illustration of microtubule‐mediated delivery and stabilization of CaV1.2 channels into enlarged plasma membrane clusters in response to Ang II or hyperglycaemia, promoting cooperative gating and enhanced Ca2+ influx. Abstract L‐type CaV1.
Miguel Martin‐Aragon Baudel, Hannah Voorhees, Arsalan U. Syed, Maryann K. Ferrara, Mary Horne, Johannes W. Hell, Luis F. Santana, Rose E. Dixon, Madeline Nieves‐Cintron, Manuel F. Navedo   +9 more
wiley   +1 more source

A‐kinase anchoring proteins (AKAPs) regulate airway smooth muscle secretory function

The FASEB Journal, 2013
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease mainly caused by cigarette smoke. Current pharmacotherapy involves β2‐agonists and phosphodiesterase inhibitors. Both drugs elevate cAMP, but relieve a distinct subset of COPD symptoms.
Wilfred J Poppinga, Anouk Oldenburger, Laura J Holtzer, Saskia Driessen, Irene H Heijink, Harm Maarsingh, Martina Schmidt   +6 more
openaire   +1 more source

A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Protein kinases (PKs) are enzymes that catalyze phosphorylation of protein substrates involved in a wide variety of biological signalling pathways. This review describes the different families and mechanisms of action and regulation of protein kinases, together with the different classes of fluorescent biosensors that have been engineered and ...
Timothe Abbura, May C. Morris
wiley   +1 more source

Liberated PKA Catalytic Subunits Associate with the Membrane via Myristoylation to Preferentially Phosphorylate Membrane Substrates

Cell Reports, 2017
Summary: Protein kinase A (PKA) has diverse functions in neurons. At rest, the subcellular localization of PKA is controlled by A-kinase anchoring proteins (AKAPs). However, the dynamics of PKA upon activation remain poorly understood.
Shane E. Tillo, Wei-Hong Xiong, Maho Takahashi, Sheng Miao, Adriana L. Andrade, Dale A. Fortin, Guang Yang, Maozhen Qin, Barbara F. Smoody, Philip J.S. Stork, Haining Zhong   +10 more
doaj   +1 more source