Results 61 to 70 of about 3,121 (209)

Subcellular drug targeting illuminates local kinase action

eLife, 2019
Deciphering how signaling enzymes operate within discrete microenvironments is fundamental to understanding biological processes. A-kinase anchoring proteins (AKAPs) restrict the range of action of protein kinases within intracellular compartments.
Paula J Bucko, Chloe K Lombard, Lindsay Rathbun, Irvin Garcia, Akansha Bhat, Linda Wordeman, F Donelson Smith, Dustin J Maly, Heidi Hehnly, John D Scott   +9 more
doaj   +1 more source

Mislocalization of protein kinase A drives pathology in Cushing's syndrome [PDF]

, 2022
Mutations in the catalytic subunit of protein kinase A (PKAc) drive the stress hormone disorder adrenal Cushing's syndrome. We define mechanisms of action for the PKAc-L205R and W196R variants. Proximity proteomic techniques demonstrate that both Cushing'
McKnight, G. Stanley, Ong, Shao-En, Omar, Mitchell, Eyers, Patrick, Collins, Kerrie, Forbush, Katherine, Forbush, KA, Eyers, Claire, Ong, SE, Eyers, Claire E., Scott, John, Baird, Geoffrey, Jones, Kiana, Lee, KS, Lefrançois-Martinez, AM, Byrne, DP, Smith, FD, Collins, KB, Byrne, Dominic P., Martinez, A, Byrne, Dominic, Jones, Kiana N., Breault, DT, Lee, Kyung-Soon, Lau, Ho-Tak, Daly, LA, Collins, Kerrie B., Daly, Leonard A., Daly, Leonard, Eyers, CE, Eyers, PA, Breault, David T., Breault, David, Eyers, Patrick A., Omar, MH, Martinez, Antoine, Smith, F. Donelson, Golkowski, Martin, Lefrançois-Martinez, Anne-Marie, Scott, John D., Lakey, TM, Baird, Geoffrey S., Lau, HT, Golkowski, M, Scott, JD, Jones, KN, Omar, Mitchell H., Forbush, Katherine A., McKnight, GS, Lakey, Tyler M., Lakey, Tyler, Baird, GS   +51 more
core   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Decreased AKAP4/PKA signaling pathway in high DFI sperm affects sperm capacitation

Asian Journal of Andrology
The sperm DNA fragmentation index (DFI) is a metric used to assess DNA fragmentation within sperm. During in vitro fertilization-embryo transfer (IVF-ET), high sperm DFI can lead to a low fertilization rate, poor embryo development, early miscarriage ...
Kun Zhang, Xiu-Hua Xu, Jian Wu, Ning Wang, Gang Li, Gui-Min Hao, Jin-Feng Cao   +6 more
doaj   +1 more source

Roles of A-Kinase Anchoring Proteins and Phosphodiesterases in the Cardiovascular System

Journal of Cardiovascular Development and Disease, 2018
A-kinase anchoring proteins (AKAPs) and cyclic nucleotide phosphodiesterases (PDEs) are essential enzymes in the cyclic adenosine 3’-5’ monophosphate (cAMP) signaling cascade.
Maria Ercu, Enno Klussmann
doaj   +1 more source

Retinoid-induced expression and activity of an immediate early tumor suppressor gene in vascular smooth muscle cells. [PDF]

PLoS ONE, 2011
Retinoids are used clinically to treat a number of hyper-proliferative disorders and have been shown in experimental animals to attenuate vascular occlusive diseases, presumably through nuclear receptors bound to retinoic acid response elements (RARE ...
Jeffrey W Streb, Xiaochun Long, Ting-Hein Lee, Qiang Sun, Chad M Kitchen, Mary A Georger, Orazio J Slivano, William S Blaner, Daniel W Carr, Irwin H Gelman, Joseph M Miano   +10 more
doaj   +1 more source

The Role of Cyclic AMP Signaling in Cardiac Fibrosis

Cells, 2019
Myocardial stress and injury invariably promote remodeling of the cardiac tissue, which is associated with cardiomyocyte death and development of fibrosis. The fibrotic process is initially triggered by the differentiation of resident cardiac fibroblasts
Marion Delaunay, Halima Osman, Simon Kaiser, Dario Diviani   +3 more
doaj   +1 more source

Metabotropic Glutamate Receptor–Dependent Synaptic Plasticity in Age‐Related Neurodegenerative Disorders

Neural Plasticity, Volume 2026, Issue 1, 2026.
Synaptic plasticity is a fundamental property of the nervous system that underpins learning, memory, and adaptive behavior across the lifespan. Disruption of plasticity mechanisms is increasingly recognized as a unifying feature of age‐related neurodegenerative and neuropsychiatric disorders.
Shaik Basha, Aradhika Vijeev, Spandana S. Nadig, Kripa Agarwal, Vibhuti Meharchandani, Aparna Ramakrishna Pai, Krishna Kishore Mahato, Suraiya Saleem   +7 more
wiley   +1 more source

Phosphodiesterase 4 cAMP phosphodiesterases as targets for novel anti-inflammatory therapeutics

Allergology International, 2004
Cyclic nucleotides are powerful signaling molecules and their sole means of removal is through the action of cyclic nucleotide phosphodiesterases (PDEs). Elevating levels of cAMP is beneficial in many diseases, including neurological conditions, cancers,
Simon J MacKenzie
doaj   +1 more source

Conserved Functions of LARP1 Proteins in Eukaryotes

WIREs RNA, Volume 16, Issue 6, November/December 2025.
LARP1 proteins are evolutionary conserved, and their function is influenced by both independent and coordinated roles of the La Motif and DM15 region, with a net effect on mRNA translation and stability. ABSTRACT La and La‐related proteins (LARPs) are conserved RNA‐binding proteins that share a characteristic La motif (LaM) and have important functions
Farnaz Mansouri‐Noori, Mark A. Bayfield   +1 more
wiley   +1 more source