Results 71 to 80 of about 115,266,211 (193)
A Novel A‐Kinase‐Anchoring Protein 9 Variant in Premature Coronary Artery Disease: A Case Series
Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.AKAP9 Q2136E mutation disrupts AKAP9–PRKAR2A interaction and may contribute to early‐onset CAD. ABSTRACT Background Familial premature coronary artery disease (CAD) is often associated with genetic variants. This study investigated potential causal variants in a Chinese pedigree with premature CAD. Methods In total, nine family members were included in
Yuemiao Jiao +7 more
wiley +1 more source
Cells, 2019 The subunits KCNQ1 and KCNE1 generate the slowly activating, delayed rectifier potassium current, IKs, that responds to sympathetic stimulation and is critical for human cardiac repolarization.
Yong Li +5 more
doaj +1 more source
Physiologic and pathophysiologic roles of AKAP12
Science Progress, 2022 A kinase anchoring protein (AKAP) 12 is a scaffolding protein that improves the specificity and efficiency of spatiotemporal signal through assembling intracellular signal proteins into a specific complex.
Hui Li
doaj +1 more source
InDel and CNV within the AKAP13 Gene Revealing Strong Associations with Growth Traits in Goat
Animals, 2023 A-kinase-anchoring protein 13 (AKAP13) is a member of the AKAP protein family that has been found to be associated with bone formation. Thus, we investigated the AKAP13 gene as a potential candidate gene for molecular-marker-assisted selection (MAS) in ...
Xiaoyue Song +5 more
doaj +1 more source
Neural Plasticity, Volume 2026, Issue 1, 2026.Synaptic plasticity is a fundamental property of the nervous system that underpins learning, memory, and adaptive behavior across the lifespan. Disruption of plasticity mechanisms is increasingly recognized as a unifying feature of age‐related neurodegenerative and neuropsychiatric disorders.
Shaik Basha +7 more
wiley +1 more source
Pharmacological ResearchRegulatory enzymes fulfill critical roles within specific subcellular compartments. Scaffolding proteins orchestrate enzyme activity and signal transduction by confining these processes to distinct spatial locations, thereby forming functional ...
Xu Wang +5 more
doaj +1 more source
Frontiers in Physiology, 2020 Our understanding of the general principles of the polymodal regulation of transient receptor potential (TRP) ion channels has grown impressively in recent years as a result of intense efforts in protein structure determination by cryo-electron ...
Lucie Zimova +8 more
doaj +1 more source
Frontiers in Synaptic Neuroscience, 2022 A-kinase anchoring protein 79-human/150-rodent (AKAP79/150) organizes signaling proteins to control synaptic plasticity. AKAP79/150 associates with the plasma membrane and endosomes through its N-terminal domain that contains three polybasic regions and ...
Xiaobing Chen +9 more
doaj +1 more source
AKAP-Lbc Anchors Protein Kinase A and Nucleates Gα12-selective Rho-mediated Stress Fiber Formation [PDF]
Journal of Biological Chemistry, 2001 Guanine nucleotide exchange factors of the Dbl family relay signals from membrane receptors to Rho family GTPases. We now demonstrate that a longer transcript of the Lbc gene encodes a chimeric molecule, which we have called AKAP-Lbc, that functions as an A-kinase-anchoring protein (AKAP) and a Rho-selective guanine nucleotide exchange factor ...
D, Diviani, J, Soderling, J D, Scott
openaire +2 more sources
Specification of spatial relationships in directed graphs of cell signaling networks [PDF]
, 2008 Graph theory provides a useful and powerful tool for the analysis of cellular signaling networks. Intracellular components such as cytoplasmic signaling proteins, transcription factors and genes are connected by links, representing various types of ...
Susana R. Neves +2 more
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