Results 71 to 80 of about 3,121 (209)

A‐kinase anchoring proteins (AKAPs) regulate airway smooth muscle secretory function

The FASEB Journal, 2013
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease mainly caused by cigarette smoke. Current pharmacotherapy involves β2‐agonists and phosphodiesterase inhibitors. Both drugs elevate cAMP, but relieve a distinct subset of COPD symptoms.
Wilfred J Poppinga, Anouk Oldenburger, Laura J Holtzer, Saskia Driessen, Irene H Heijink, Harm Maarsingh, Martina Schmidt   +6 more
openaire   +1 more source

Guanine Nucleotide Exchange Factors and Small GTPases: Their Regulation and Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 10, October 2025.
This review comprehensively examines the regulatory mechanisms and physiological roles of guanine nucleotide exchange factors (GEFs) and their small GTPase substrates, highlighting their significance in cellular processes and disease pathogenesis.
Zexing Lin, Chujun Ni, Haiyang Jiang, Huan Yang, Liting Deng, Peizhao Liu, Xuanheng Li, Yilong Yu, Weijie Li, Runnan Wang, Bo Liao, Jiaqi Kang, Juanhan Liu, Xiuwen Wu, Jianan Ren, Yun Zhao   +15 more
wiley   +1 more source

Liberated PKA Catalytic Subunits Associate with the Membrane via Myristoylation to Preferentially Phosphorylate Membrane Substrates

Cell Reports, 2017
Summary: Protein kinase A (PKA) has diverse functions in neurons. At rest, the subcellular localization of PKA is controlled by A-kinase anchoring proteins (AKAPs). However, the dynamics of PKA upon activation remain poorly understood.
Shane E. Tillo, Wei-Hong Xiong, Maho Takahashi, Sheng Miao, Adriana L. Andrade, Dale A. Fortin, Guang Yang, Maozhen Qin, Barbara F. Smoody, Philip J.S. Stork, Haining Zhong   +10 more
doaj   +1 more source

Physiologic and pathophysiologic roles of AKAP12

Science Progress, 2022
A kinase anchoring protein (AKAP) 12 is a scaffolding protein that improves the specificity and efficiency of spatiotemporal signal through assembling intracellular signal proteins into a specific complex.
Hui Li
doaj   +1 more source

InDel and CNV within the AKAP13 Gene Revealing Strong Associations with Growth Traits in Goat

Animals, 2023
A-kinase-anchoring protein 13 (AKAP13) is a member of the AKAP protein family that has been found to be associated with bone formation. Thus, we investigated the AKAP13 gene as a potential candidate gene for molecular-marker-assisted selection (MAS) in ...
Xiaoyue Song, Yangyang Bai, Rongrong Yuan, Haijing Zhu, Xianyong Lan, Lei Qu   +5 more
doaj   +1 more source

A Systematic Evaluation of Protein Kinase A–A-Kinase Anchoring Protein Interaction Motifs

, 2016
Protein kinase A (PKA) in vertebrates is localized to specific locations in the cell via A-kinase anchoring proteins (AKAPs). The regulatory subunits of the four PKA isoforms (RIα, RIβ, RIIα, and RIIβ) each form a homodimer, and their dimerization domain
Albert J. R. Heck (1293345), Marcel A. G. van der Heyden (1664950), Pepijn P. Burgers (1690951), Bart Kok (517822), Arjen Scholten (1293336)   +4 more
core   +1 more source

Neurobeachin (NBEA) is a novel gene associated with GLP‐1 receptor agonist associated weight loss

Diabetes, Obesity and Metabolism, Volume 27, Issue 10, Page 5632-5642, October 2025.
Abstract Aims Nearly 42% of adults in the United States have obesity, a significant risk factor for many cardiometabolic diseases and cancers. Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) are promising interventions for weight loss, but their efficacy varies significantly across individuals.
Arshiya Mariam‐Smith, Joseph H. Breeyear, Noah J. Daniels, Kevin M. Pantalone, Marcio L. Griebeler, Alison A. Motsinger‐Reif, Daniel M. Rotroff   +6 more
wiley   +1 more source

Regulation of I_Ks Potassium Current by Isoproterenol in Adult Cardiomyocytes Requires Type 9 Adenylyl Cyclase

Cells, 2019
The subunits KCNQ1 and KCNE1 generate the slowly activating, delayed rectifier potassium current, IKs, that responds to sympathetic stimulation and is critical for human cardiac repolarization.
Yong Li, Thomas Hof, Tanya A. Baldwin, Lei Chen, Robert S. Kass, Carmen W. Dessauer   +5 more
doaj   +1 more source

Palmitoylation of A-kinase anchoring protein 79/150 modulates its nanoscale organization, trafficking, and mobility in postsynaptic spines

Frontiers in Synaptic Neuroscience, 2022
A-kinase anchoring protein 79-human/150-rodent (AKAP79/150) organizes signaling proteins to control synaptic plasticity. AKAP79/150 associates with the plasma membrane and endosomes through its N-terminal domain that contains three polybasic regions and ...
Xiaobing Chen, Kevin C. Crosby, Austin Feng, Alicia M. Purkey, Maria A. Aronova, Christine A. Winters, Virginia T. Crocker, Richard D. Leapman, Thomas S. Reese, Mark L. Dell’Acqua   +9 more
doaj   +1 more source

A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains

The FEBS Journal, Volume 292, Issue 17, Page 4477-4486, September 2025.
Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley   +1 more source