Results 91 to 100 of about 3,121 (209)

Domain architecture of a Caenorhabditis elegans AKAP suggests a novel AKAP function [PDF]

, 2020
A-kinase anchoring proteins (AKAPs) are adapter proteins that are involved in directing cAMP-dependent protein kinase and some other signaling enzymes to certain intracellular locations.

core  

Cytosolic‐enhanced dark Epac‐based FRET sensors allow for intracellular cAMP detection in live cells via FLIM

FEBS Letters, Volume 599, Issue 7, Page 1075-1085, April 2025.
We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti, Jeffrey B. Klarenbeek, Kees Jalink   +2 more
wiley   +1 more source

Milestone Review: Unlocking the Proteomics of Glycine Receptor Complexes

Journal of Neurochemistry, Volume 169, Issue 4, April 2025.
Glycine receptors (GlyRs) play key roles in brain development, learning/memory, inflammatory pain sensitization, and rhythmic breathing. GlyRs depend upon stable and transient protein–protein interactions that influence synaptic localization, homeostasis, signaling pathways, and receptor function.
Sean D. Fraser, Remco V. Klaassen, Carmen Villmann, August B. Smit, Robert J. Harvey   +4 more
wiley   +1 more source

Gpr55 deficiency crucially alters cardiomyocyte homeostasis and counteracts angiotensin II induced maladaption in female mice

British Journal of Pharmacology, Volume 182, Issue 3, Page 670-691, February 2025.
Background and Purpose Cannabis stimulates several G‐protein‐coupled‐receptors and causes bradycardia and hypotension upon sustained consumption. Moreover, in vitro studies suggest an interference of cannabinoid‐signalling with cardiomyocyte contractility and hypertrophy.
Brigitte Schopohl, Michael Kohlhaas, Alexander G. Nickel, Anna‐Florentine Schiuma, Sanne L. Maas, Emiel P. C. van der Vorst, Yi Xuan Shia, Christoph Maack, Sabine Steffens, Sarah‐Lena Puhl   +9 more
wiley   +1 more source

Identification of a-kinase anchoring protein (AKAP) 150 in dispersed chief cells from guinea pig stomach

Gastroenterology, 2000
Guofeng Xie, Jean‐Pierre Raufman
openalex   +2 more sources

Serum response factor mediates nociceptor inflammatory pain plasticity

PAIN Reports, 2018
. Introduction:. Chronic metabotropic glutamate receptor activation in nociceptive afferents may upregulate A-Kinase Anchoring Protein 150 (AKAP150) expression and/or function. Objectives:. To quantify transcriptional changes in AKAP150 expression and/or
Ruben Gomez, Dorothy M. Kohler, Allison D. Brackley, Michael A. Henry, Nathaniel A. Jeske   +4 more
doaj   +1 more source

Regulation of g protein-coupled receptor signaling by a-kinase anchoring proteins

, 2006
Specificity of transduction events is controlled at the molecular level by scaffold, anchoring, and adaptor proteins, which position signaling enzymes at proper subcellular localization.
Diviani, D., Appert-Collin, A., Baisamy, L.   +2 more
core   +1 more source

Possible Involvement of Hippocampal miR‐539‐3p/Lrp6/Igf1r Axis for Diminished Working Memory in Mice Fed a Low‐Carbohydrate and High‐Protein Diet

Molecular Nutrition &Food Research, Volume 69, Issue 2, January 2025.
We tested the effects of feeding low‐carbohydrate and high‐protein (LC‐HP) diets over a span of four weeks on hippocampal working memory in healthy mice and the alterations in hippocampal miRNA profiles to gain insight into the modulation of hippocampal function.
Takeru Shima, Hayate Onishi, Chiho Terashima   +2 more
wiley   +1 more source

Cigarette smoke and A‐kinase anchoring proteins (AKAPs) in human airway smooth muscle function

The FASEB Journal, 2011
COPD is a chronic inflammatory disease mainly caused by cigarette smoke (CS) and characterized by infiltration of (activated) inflammatory cells. Airway smooth muscle (ASM) also contribute to inflammatory cytokine release, smooth muscle contraction, and airway remodeling. Notably, cAMP‐elevating β 2
Martina Schmidt, Anouk Oldenburger, Wilfred Poppinga, Sara S Roscioni, Irene H Heijink, Wim Timens, Philip Skroblin, Enno Klussmann, Harm Maarsingh   +8 more
openaire   +1 more source

Anchored protein kinase A signalling in cardiac cellular electrophysiology

, 2014
The cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) is an elementary molecule involved in both acute and chronic modulation of cardiac function.
Scholten, Arjen, Vos, Marc A, van Veen, Toon A B, Soni, Siddarth   +3 more
core   +2 more sources