Results 91 to 100 of about 115,266,211 (193)

Mechanism of activation of NDR protein kinase by the HMOB1 protein [PDF]

, 2005
Serine/threonine kinases of the nuclear Dbf2-related (NDR) family are highly conserved throughout the eukaryotic world. Members of this kinase family are implicated in various aspects of the regulation of cell division and cell morphology. It has been
Bichsel, Samuel J.
core   +1 more source

Extramitochondrial OPA1 and adrenocortical function [PDF]

, 2013
We have previously described that silencing of the mitochondrial protein OPA1 enhances mitochondrial 27 Ca2+ signaling and aldosterone production in H295R adrenocortical cells.
Fülöp, László, Spät András, Szanda, Gergö, Katona, Dávid, Rajki Anikó, Rajki, Anikó, Fülöp László, Szanda Gergő, Spät, András, Katona Dávid   +9 more
core   +2 more sources

Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP

Cells, 2020
Arginine-vasopressin (AVP) facilitates water reabsorption in renal collecting duct principal cells through regulation of the water channel aquaporin-2 (AQP2).
Alessandro Dema, Dörte Faust, Katina Lazarow, Marc Wippich, Martin Neuenschwander, Kerstin Zühlke, Andrea Geelhaar, Tamara Pallien, Eileen Hallscheidt, Jenny Eichhorst, Burkhard Wiesner, Hana Černecká, Oliver Popp, Philipp Mertins, Gunnar Dittmar, Jens Peter von Kries, Enno Klussmann   +16 more
doaj   +1 more source

Allosteric modulation of protein kinase A in individuals affected by NLPD‐PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed

The FEBS Journal, Volume 292, Issue 18, Page 4808-4832, September 2025.
In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman, Valeria Pane, Rania Safadi‐Safa, Meir Solomon, Varda Lev‐Ram, Mohammad Aboraya, Anwar Dakwar, Daniela Bertinetti, Andrew Hoy, Merel O. Mol, John van Swieten, Rodrigo Maillard, Friedrich W. Herberg, Ronit Ilouz   +13 more
wiley   +1 more source

Protein kinase A: a quirky prototype

The FEBS Journal, Volume 292, Issue 18, Page 4800-4803, September 2025.
Protein kinase A (PKA) has served as a prototype for establishing kinase fundamentals, including sequence, structure and catalytic mechanism. However, PKA is quirky in some respects. Its regulatory elements are expressed separately, including type I (RI) regulatory subunits that contain unusual disulphide‐linked dimerization and docking domains ...
Matthew G. Gold
wiley   +1 more source

Cytoplasmic Anchoring of cAMP-Dependent Protein Kinase (PKA) by A-Kinase Anchor Proteins (AKAPs) Is Required for Meiotic Arrest of Porcine Full-Grown and Growing Oocytes1

Biology of Reproduction, 2014
Mammalian growing oocytes (GOs) lack the ability to resume meiosis, although the molecular mechanism of this limitation is not fully understood. We previously hypothesized that the meiotic incompetence of porcine GOs was attributed to complex spatial-temporal regulation of cAMP-dependent protein kinase (PKA) by A-kinase anchor proteins (AKAPs), but ...
Takanori Nishimura, Wataru Fujii, Koji Sugiura, Kunihiko Naito   +3 more
openaire   +3 more sources

Serum response factor mediates nociceptor inflammatory pain plasticity

PAIN Reports, 2018
. Introduction:. Chronic metabotropic glutamate receptor activation in nociceptive afferents may upregulate A-Kinase Anchoring Protein 150 (AKAP150) expression and/or function. Objectives:. To quantify transcriptional changes in AKAP150 expression and/or
Ruben Gomez, Dorothy M. Kohler, Allison D. Brackley, Michael A. Henry, Nathaniel A. Jeske   +4 more
doaj   +1 more source

ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system

British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.
G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison, Clauda Abboud, Dayana Abboud, Abdulrasheed O. Abdulrahman, Ana‐Nicoleta Bondar, Julie Dam, Zafiroula Georgoussi, Jesús Giraldo, Anemari Horvat, Christos Karoussiotis, Alba Paz‐Castro, Miriam Scarpa, Hannes Schihada, Nicole Scholz, Bilge Güvenc Tuna, Nina Vardjan   +15 more
wiley   +1 more source

Novel insight into the role of A-kinase anchoring proteins (AKAPs) in ischemic stroke and therapeutic potentials

Biomedicine & Pharmacotherapy
Ischemic stroke, a devastating disease associated with high mortality and disability worldwide, has emerged as an urgent public health issue. A-kinase anchoring proteins (AKAPs) are a group of signal-organizing molecules that compartmentalize and anchor a wide range of receptors and effector proteins and have a major role in stabilizing mitochondrial ...
Ziyu, He, Letian, Xie, Jiyong, Liu, Xuan, Wei, Wenli, Zhang, Zhigang, Mei   +5 more
openaire   +2 more sources

Cigarette smoke and A‐kinase anchoring proteins (AKAPs) in human airway smooth muscle function

The FASEB Journal, 2011
COPD is a chronic inflammatory disease mainly caused by cigarette smoke (CS) and characterized by infiltration of (activated) inflammatory cells. Airway smooth muscle (ASM) also contribute to inflammatory cytokine release, smooth muscle contraction, and airway remodeling. Notably, cAMP‐elevating β 2
Martina Schmidt, Anouk Oldenburger, Wilfred Poppinga, Sara S Roscioni, Irene H Heijink, Wim Timens, Philip Skroblin, Enno Klussmann, Harm Maarsingh   +8 more
openaire   +1 more source