Results 81 to 90 of about 115,266,211 (193)

Conserved Functions of LARP1 Proteins in Eukaryotes

WIREs RNA, Volume 16, Issue 6, November/December 2025.
LARP1 proteins are evolutionary conserved, and their function is influenced by both independent and coordinated roles of the La Motif and DM15 region, with a net effect on mRNA translation and stability. ABSTRACT La and La‐related proteins (LARPs) are conserved RNA‐binding proteins that share a characteristic La motif (LaM) and have important functions
Farnaz Mansouri‐Noori, Mark A. Bayfield   +1 more
wiley   +1 more source

Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79.

Journal of Biological Chemistry, 1992
Postsynaptic densities (PSD) are a network of proteins located on the internal surface of excitatory synapses just inside the postsynaptic membrane. Enzymes associated with the PSD are optimally positioned to respond to signals transduced across the postsynaptic membrane resulting from excitatory synaptic transmission or neurotransmitter release.
D W, Carr, R E, Stofko-Hahn, I D, Fraser, R D, Cone, J D, Scott   +4 more
openaire   +2 more sources

Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C

BMC Cell Biology, 2011
Background Cardiac contractility is regulated by dynamic phosphorylation of sarcomeric proteins by kinases such as cAMP-activated protein kinase A (PKA).
Riedemann Johann, Mouton Jomien, Korkie Lundi J, Kinnear Craig J, Loos Benjamin, Ramburan Amsha, Uys Gerrida M, Moolman-Smook Johanna C   +7 more
doaj   +1 more source

Guanine Nucleotide Exchange Factors and Small GTPases: Their Regulation and Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 10, October 2025.
This review comprehensively examines the regulatory mechanisms and physiological roles of guanine nucleotide exchange factors (GEFs) and their small GTPase substrates, highlighting their significance in cellular processes and disease pathogenesis.
Zexing Lin, Chujun Ni, Haiyang Jiang, Huan Yang, Liting Deng, Peizhao Liu, Xuanheng Li, Yilong Yu, Weijie Li, Runnan Wang, Bo Liao, Jiaqi Kang, Juanhan Liu, Xiuwen Wu, Jianan Ren, Yun Zhao   +15 more
wiley   +1 more source

Anchored protein kinase A signalling in cardiac cellular electrophysiology [PDF]

, 2014
The cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) is an elementary molecule involved in both acute and chronic modulation of cardiac function.
Scholten, Arjen, Vos, Marc A, van Veen, Toon A B, Soni, Siddarth   +3 more
core   +2 more sources

Neurobeachin (NBEA) is a novel gene associated with GLP‐1 receptor agonist associated weight loss

Diabetes, Obesity and Metabolism, Volume 27, Issue 10, Page 5632-5642, October 2025.
Abstract Aims Nearly 42% of adults in the United States have obesity, a significant risk factor for many cardiometabolic diseases and cancers. Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) are promising interventions for weight loss, but their efficacy varies significantly across individuals.
Arshiya Mariam‐Smith, Joseph H. Breeyear, Noah J. Daniels, Kevin M. Pantalone, Marcio L. Griebeler, Alison A. Motsinger‐Reif, Daniel M. Rotroff   +6 more
wiley   +1 more source

The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates α1 adrenergic receptor-induced cardiomyocyte hypertrophy [PDF]

Proceedings of the National Academy of Sciences, 2007
In response to various pathological stresses, the heart undergoes a pathological remodeling process that is associated with cardiomyocyte hypertrophy. Because cardiac hypertrophy can progress to heart failure, a major cause of lethality worldwide, the intracellular signaling pathways that control cardiomyocyte growth have been the subject of intensive ...
APPERT COLLIN A, NENNIGER TOSATO M, PEDRAZZINI T, DIVIANI D., COTECCHIA, Susanna   +4 more
openaire   +3 more sources

AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP

Cell Reports, 2018
Summary: Ca2+-permeable AMPA-type glutamate receptors (CP-AMPARs) containing GluA1 but lacking GluA2 subunits contribute to multiple forms of synaptic plasticity, including long-term potentiation (LTP), but mechanisms regulating CP-AMPARs are poorly ...
Alicia M. Purkey, Kevin M. Woolfrey, Kevin C. Crosby, Dominik G. Stich, Wallace S. Chick, Jason Aoto, Mark L. Dell’Acqua   +6 more
doaj   +1 more source

A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains

The FEBS Journal, Volume 292, Issue 17, Page 4477-4486, September 2025.
Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley   +1 more source

A Systematic Evaluation of Protein Kinase A–A-Kinase Anchoring Protein Interaction Motifs

, 2016
Protein kinase A (PKA) in vertebrates is localized to specific locations in the cell via A-kinase anchoring proteins (AKAPs). The regulatory subunits of the four PKA isoforms (RIα, RIβ, RIIα, and RIIβ) each form a homodimer, and their dimerization domain
Albert J. R. Heck (1293345), Marcel A. G. van der Heyden (1664950), Pepijn P. Burgers (1690951), Bart Kok (517822), Arjen Scholten (1293336)   +4 more
core   +1 more source