Results 81 to 90 of about 3,121 (209)

AKAP95: A multifunctional scaffold kinase anchoring protein, role in pathophysiology and perspectives for its therapeutic use

Pharmacological Research
Regulatory enzymes fulfill critical roles within specific subcellular compartments. Scaffolding proteins orchestrate enzyme activity and signal transduction by confining these processes to distinct spatial locations, thereby forming functional ...
Xu Wang, Jinlian He, Gangyuan Ma, Feng Zhou, Liqing Chen, Liang Liu   +5 more
doaj   +1 more source

Proximal C-Terminus Serves as a Signaling Hub for TRPA1 Channel Regulation via Its Interacting Molecules and Supramolecular Complexes

Frontiers in Physiology, 2020
Our understanding of the general principles of the polymodal regulation of transient receptor potential (TRP) ion channels has grown impressively in recent years as a result of intense efforts in protein structure determination by cryo-electron ...
Lucie Zimova, Kristyna Barvikova, Lucie Macikova, Lucie Macikova, Lenka Vyklicka, Viktor Sinica, Viktor Sinica, Ivan Barvik, Viktorie Vlachova   +8 more
doaj   +1 more source

Allosteric modulation of protein kinase A in individuals affected by NLPD‐PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed

The FEBS Journal, Volume 292, Issue 18, Page 4808-4832, September 2025.
In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman, Valeria Pane, Rania Safadi‐Safa, Meir Solomon, Varda Lev‐Ram, Mohammad Aboraya, Anwar Dakwar, Daniela Bertinetti, Andrew Hoy, Merel O. Mol, John van Swieten, Rodrigo Maillard, Friedrich W. Herberg, Ronit Ilouz   +13 more
wiley   +1 more source

Mechanisms of protein kinase A anchoring

, 2010
The second messenger cyclic adenosine monophosphate (cAMP), which is produced by adenylyl cyclases following stimulation of G-protein-coupled receptors, exerts its effect mainly through the cAMP-dependent serine/threonine protein kinase A (PKA).
Rosenthal, W., Solveig Grossmann, Skroblin, P., Schaefer, G., Philipp Skroblin, Walter Rosenthal, Enno Klussmann, Gesa Schäfer, Grossmann, S., Klussmann, E.   +9 more
core   +1 more source

Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C

BMC Cell Biology, 2011
Background Cardiac contractility is regulated by dynamic phosphorylation of sarcomeric proteins by kinases such as cAMP-activated protein kinase A (PKA).
Riedemann Johann, Mouton Jomien, Korkie Lundi J, Kinnear Craig J, Loos Benjamin, Ramburan Amsha, Uys Gerrida M, Moolman-Smook Johanna C   +7 more
doaj   +1 more source

ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system

British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.
G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison, Clauda Abboud, Dayana Abboud, Abdulrasheed O. Abdulrahman, Ana‐Nicoleta Bondar, Julie Dam, Zafiroula Georgoussi, Jesús Giraldo, Anemari Horvat, Christos Karoussiotis, Alba Paz‐Castro, Miriam Scarpa, Hannes Schihada, Nicole Scholz, Bilge Güvenc Tuna, Nina Vardjan   +15 more
wiley   +1 more source

HT31: THE first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling

, 2001
In an attempt to isolate protein kinase A anchoring proteins (AKAPs) involved in vasopressin-mediated water reabsorbtion, the complete sequence of the human AKAP Ht31 was determined and a partial cDNA of its rat orthologue (Rt31) was cloned.
KLAUSCHENZ E, MARIC K, EDEMIR B, HUNDSRUCKER C, KLUSSMANN E, PEPPERLE B, TAMMA, GRAZIA, HENN V, ROSENTHAL W.   +8 more
core   +1 more source

Toward Design Principles for Biomolecular Condensates for Metabolic Pathways

Advanced Biology, Volume 9, Issue 5, May 2025.
Biomolecular condensates are membrane‐less compartments found through‐out nature which can serve as reaction crucibles for biochemical processes. This review explores the design strategies underlying how condensates can be used in biotechnology to enhance multistep enzyme cascades including enhancement by mass action and substrate channeling, and ...
Alain A.M. André, Nikita Rehnberg, Ankush Garg, Magnus Kjærgaard   +3 more
wiley   +1 more source

AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP

Cell Reports, 2018
Summary: Ca2+-permeable AMPA-type glutamate receptors (CP-AMPARs) containing GluA1 but lacking GluA2 subunits contribute to multiple forms of synaptic plasticity, including long-term potentiation (LTP), but mechanisms regulating CP-AMPARs are poorly ...
Alicia M. Purkey, Kevin M. Woolfrey, Kevin C. Crosby, Dominik G. Stich, Wallace S. Chick, Jason Aoto, Mark L. Dell’Acqua   +6 more
doaj   +1 more source

Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP

Cells, 2020
Arginine-vasopressin (AVP) facilitates water reabsorption in renal collecting duct principal cells through regulation of the water channel aquaporin-2 (AQP2).
Alessandro Dema, Dörte Faust, Katina Lazarow, Marc Wippich, Martin Neuenschwander, Kerstin Zühlke, Andrea Geelhaar, Tamara Pallien, Eileen Hallscheidt, Jenny Eichhorst, Burkhard Wiesner, Hana Černecká, Oliver Popp, Philipp Mertins, Gunnar Dittmar, Jens Peter von Kries, Enno Klussmann   +16 more
doaj   +1 more source