Results 101 to 110 of about 3,121 (209)
, 2015 Pathological cardiac hypertrophy (an increase in cardiac mass resulting from stress-induced cardiac myocyte growth) is a major factor underlying heart failure.
O'Bryan, JP +5 more
core
Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins [PDF]
, 2018 A-kinase anchoring proteins (AKAPs) shape second-messenger signaling responses by constraining protein kinase A (PKA) at precise intracellular locations.
Navedo, Manuel F +14 more
core +1 more source
The FEBS Journal, Volume 292, Issue 2, Page 261-271, January 2025.Adipocyte function is regulated by all three β‐adrenergic receptor subtypes via the second messenger cAMP. This type of signaling is highly confined in subcellular microdomains or signalosomes by the action of various phosphodiesterase (PDE) families. This review highlights recent insights into cAMP compartmentation in white and brown adipocytes gained
Kirstie A. De Jong +3 more
wiley +1 more source
Control of PKA stability and signalling by RING ligase praja2
, 2010 Ligand-mediated activation of G-Protein Coupled Receptors (GPCRs) mobilises compartmentalised pulses of second messengers like cAMP. The main cellular effector of cAMP is Protein Kinase A (PKA) which is assembled as inactive holoenzyme consisting of two ...
Lignitto, Luca
core
Exploring the Common Mutational Landscape in Cutaneous Melanoma and Pancreatic Cancer
Pigment Cell &Melanoma Research, Volume 38, Issue 1, January 2025.ABSTRACT Cutaneous melanoma (CM) and pancreatic cancer are aggressive tumors whose incidences are rapidly increasing in the last years. This review aims to provide a complete and update description about mutational landscape in CM and pancreatic cancer, focusing on similarities of these two apparently so different tumors in terms of site, type of cell ...
Elisabetta Broseghini +9 more
wiley +1 more source
The FASEB Journal, Volume 38, Issue 22, 30 November 2024.We generated total knockout (KO) mice completely lacking the Cep215/Cdk5rap2 gene and investigated its specific contributions to male germ cell development. Development of male germ cells is arrested around the zygotene stage of meiosis in Cep215 KO mice.
Donghee Kang +5 more
wiley +1 more source
Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4
Journal of Neuroinflammation, 2018 Background Evidence indicates a cross-regulation between two kinases, leucine-rich repeat kinase 2 (LRRK2) and protein kinase A (PKA). In neurons, LRRK2 negatively regulates PKA activity in spiny projecting neurons during synaptogenesis and in response ...
Isabella Russo +8 more
doaj +1 more source
Extramitochondrial OPA1 and adrenocortical function [PDF]
, 2013 We have previously described that silencing of the mitochondrial protein OPA1 enhances mitochondrial 27 Ca2+ signaling and aldosterone production in H295R adrenocortical cells.
Fülöp, László +9 more
core +1 more source
Functional Analysis of the Protein Kinase A Anchoring Protein Ht31
, 2005 Titelblatt und Inhaltsverzeichnis Abkürzungsverzeichnis Einleitung Material und Methoden Ergebnisse Diskussion Zusammenfassung / Summary Literaturverzeichnis Danksagungen, LebenslaufAKAP-Ht31/AKAP-Lbc gehört zu der Familie der A kinase ...
Blum, Christopher Thorsten Friedrich
core +1 more source
Direct AKAP-mediated protein-protein interactions as potential drug targets
, 2008 A-kinase-anchoring proteins (AKAPs) are a diverse family of about 50 scaffolding proteins. They are defined by the presence of a structurally conserved protein kinase A (PKA)-binding domain.
Hundsrucker, Christian +4 more
core +1 more source