Results 121 to 130 of about 3,121 (209)

An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria

, 2011
A-kinase anchoring proteins (AKAPs) tether the cAMP-dependent protein kinase (PKA) to intracellular sites where they preferentially phosphorylate target substrates. Most AKAPs exhibit nanomolar affinity for the regulatory (RII) subunit of the type II PKA
Matthew G. Gold, Anne N. Murphy, Amanda L. Vega, John D. Scott, Luis F. Santana, Taekjip Ha, Christopher K. Means, Rose E. Dixon, Birgitte Lygren, Ankur Jain, Kjetil Tasken, Susan S. Taylor, Lorene K. Langeberg, Susanna Petrosyan   +13 more
core   +1 more source

Xgravin-like (Xgl), a novel putative a-kinase anchoring protein (AKAP) expressed during embryonic development in Xenopus

Mechanisms of Development, 2001
A-kinase anchoring proteins (AKAPs) are a heterogeneous family of scaffolding proteins that regulate the compartmentalization of signaling components, in particular that of the broad specificity kinase PKA. Here we describe the identification of a new member of this gene family, termed Xenopus gravin-like (Xgl), which encodes a highly acidic protein of
Klingbeil, Pamela, Frazzetto, Giovanni, Bouwmeester, Tewis   +2 more
openaire   +2 more sources

Localization of SSeCKS in unmyelinated primary sensory neurons

Journal of Brachial Plexus and Peripheral Nerve Injury, 2008
Background SSeCKS (Src SupprEssed C Kinase Substrate) is a proposed protein kinase C substrate/A kinase anchoring protein (AKAP) that has recently been characterized in the rat peripheral nervous system.
Siegel Sandra M, Irmen Christopher P, Carr Patrick A   +2 more
doaj   +1 more source

AKAP-Lbc: a molecular scaffold for the integration of cyclic AMP and Rho transduction pathways

, 2006
A Kinase-anchoring proteins (AKAPs) are a family of functionally related proteins involved in the targeting of the PKA holoenzyme towards specific physiological substrates. We have recently identified a novel anchoring protein expressed in cardiomyocytes,
Diviani, D., Appert-Collin, A., Baisamy, L.   +2 more
core   +1 more source

Anchoring of protein kinase A-regulatory subunit II alpha to subapically positioned centrosomes mediates apical bile canalicular lumen development in response to oncostatin m but not cAMP [PDF]

, 2007
Oncostatin M and cAMP signaling stimulate apical surface-directed membrane trafficking and apical lumen development in hepatocytes, both in a protein kinase A (PKA)-dependent manner.
Hoekstra, Dick, van Ijzendoorn, Sven C. D., Wojtal, Kacper A.   +2 more
core   +1 more source

Murine AKAP7 Has a 2′,5′-Phosphodiesterase Domain That Can Complement an Inactive Murine Coronavirus ns2 Gene

mBio, 2014
Viral 2′,5′-phosphodiesterases (2′,5′-PDEs) help disparate RNA viruses evade the antiviral activity of interferon (IFN) by degrading 2′,5′-oligoadenylate (2-5A) activators of RNase L.
Elona Gusho, Rong Zhang, Babal K. Jha, Joshua M. Thornbrough, Beihua Dong, Christina Gaughan, Ruth Elliott, Susan R. Weiss, Robert H. Silverman   +8 more
doaj   +1 more source

A-Kinase-Anchoring Protein-Lbc Anchors IκB Kinase β To Support Interleukin-6-Mediated Cardiomyocyte Hypertrophy.

, 2013
In response to stress, the heart undergoes a pathological remodeling process associated with hypertrophy and the reexpression of a fetal gene program that ultimately causes cardiac dysfunction and heart failure.
COTECCHIA, Susanna, Diviani, D., Cotecchia, S., Diviani D., Del Vescovo CD, del Vescovo, C.D.   +5 more
core   +1 more source

Protein Kinase A Regulates Platelet Phosphodiesterase 3A through an A-Kinase Anchoring Protein Dependent Manner

Cells
Platelet activation is critical for haemostasis, but if unregulated can lead to pathological thrombosis. Endogenous platelet inhibitory mechanisms are mediated by prostacyclin (PGI2)-stimulated cAMP signalling, which is regulated by phosphodiesterase 3A (
Jawad S. Khalil, Robert Law, Zaher Raslan, Lih T. Cheah, Matthew S. Hindle, Ahmed A. Aburima, Mark T. Kearney, Khalid M. Naseem   +7 more
doaj   +1 more source

The effects of disruption of A kinase anchoring protein-protein kinase A association on protein kinase A signalling in neuroendocrine melanotroph cells of Xenopus laevis

, 2006
The secretory activity of melanotroph cells from Xenopus laevis is regulated by multiple neurotransmitters that act through adenylyl cyclase. Cyclic adenosine monophosphate (cAMP), acting on protein kinase A (PKA), stimulates the frequency of ...
Hurk, M.J.J. van den, Roubos, E.W., Corstens, G.J.H., Jenks, B.G., Boxtel, R. van   +4 more
core   +1 more source

Autophagosomes anchor an AKAP11-dependent regulatory checkpoint that shapes neuronal PKA signaling

The EMBO Journal
Protein Kinase A (PKA) is regulated spatially and temporally via scaffolding of its catalytic (Cα) and regulatory (RI/RII) subunits by the A-kinase-anchoring proteins (AKAP). By binding to an AKAP11 scaffold, PKA engages in poorly understood interactions
Ashley Segura-Roman, Y Rose Citron, Myungsun Shin, Nicole Sindoni, Alex Maya-Romero, Simon Rapp, Claire Goul, Joseph D Mancias, Roberto Zoncu   +8 more
doaj   +1 more source