Results 121 to 130 of about 115,266,211 (193)

Autophagosomes anchor an AKAP11-dependent regulatory checkpoint that shapes neuronal PKA signaling

The EMBO Journal
Protein Kinase A (PKA) is regulated spatially and temporally via scaffolding of its catalytic (Cα) and regulatory (RI/RII) subunits by the A-kinase-anchoring proteins (AKAP). By binding to an AKAP11 scaffold, PKA engages in poorly understood interactions
Ashley Segura-Roman, Y Rose Citron, Myungsun Shin, Nicole Sindoni, Alex Maya-Romero, Simon Rapp, Claire Goul, Joseph D Mancias, Roberto Zoncu   +8 more
doaj   +1 more source

An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria

, 2011
A-kinase anchoring proteins (AKAPs) tether the cAMP-dependent protein kinase (PKA) to intracellular sites where they preferentially phosphorylate target substrates. Most AKAPs exhibit nanomolar affinity for the regulatory (RII) subunit of the type II PKA
Matthew G. Gold, Anne N. Murphy, Amanda L. Vega, John D. Scott, Luis F. Santana, Taekjip Ha, Christopher K. Means, Rose E. Dixon, Birgitte Lygren, Ankur Jain, Kjetil Tasken, Susan S. Taylor, Lorene K. Langeberg, Susanna Petrosyan   +13 more
core   +1 more source

AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway.

, 2008
Elevated catecholamines in the heart evoke transcriptional activation of the Myocyte Enhancer Factor (MEF) pathway to induce a cellular response known as pathological myocardial hypertrophy.
Pedroja, B.S., Kunkel, M.T., Diviani, D., Zhang, F., Langeberg, L.K., Bristow, M.R., Newton, A.C., Carnegie, G.K., Smith, F.D., Soughayer, J., Scott, J.D.   +10 more
core   +1 more source

Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes.

The Journal of biological chemistry, 1996
Compartmentalization of the type II cyclic AMP-dependent kinase (PKA) is achieved through association of the regulatory subunit (RII) with A-kinase anchoring proteins (AKAPs). Using an interaction cloning strategy with RIIalpha as a probe, we have isolated cDNAs encoding a novel 1129-amino acid protein that contains both a PKA binding region and a ...
L B, Lester, V M, Coghlan, B, Nauert, J D, Scott   +3 more
openaire   +1 more source

AKAP-Lbc: a molecular scaffold for the integration of cyclic AMP and Rho transduction pathways

, 2006
A Kinase-anchoring proteins (AKAPs) are a family of functionally related proteins involved in the targeting of the PKA holoenzyme towards specific physiological substrates. We have recently identified a novel anchoring protein expressed in cardiomyocytes,
Diviani, D., Appert-Collin, A., Baisamy, L.   +2 more
core   +1 more source

GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function

Nature Communications
Glucagon-like peptide-1 receptor (GLP-1R) agonists (GLP-1RAs) ameliorate mitochondrial health by increasing mitochondrial turnover in metabolically relevant tissues.
Gregory Austin, Affiong I. Oqua, Liliane El Eid, Mingli Zhu, Yusman Manchanda, Priyanka Peres, Helena Coyle, Yelyzaveta Poliakova, Zhanna Balkhiyarova, Karim Bouzakri, Alex Montoya, Dominic J. Withers, Michele Solimena, Ben Jones, Steven J. Millership, Steffen Burgold, David C. A. Gaboriau, Endre Majorovits, Evelyn Garlick, Maria Augusta do R. B. F. Lima, Inga Prokopenko, Jonathon Nixon-Abell, Andreas Müller, Alejandra Tomas   +23 more
doaj   +1 more source

A-Kinase-Anchoring Protein-Lbc Anchors IκB Kinase β To Support Interleukin-6-Mediated Cardiomyocyte Hypertrophy.

, 2013
In response to stress, the heart undergoes a pathological remodeling process associated with hypertrophy and the reexpression of a fetal gene program that ultimately causes cardiac dysfunction and heart failure.
COTECCHIA, Susanna, Diviani, D., Cotecchia, S., Diviani D., Del Vescovo CD, del Vescovo, C.D.   +5 more
core   +1 more source

Malaria protein kinase CK2 (PfCK2) shows novel mechanisms of regulation [PDF]

, 2014
Casein kinase 2 (protein kinase CK2) is a conserved eukaryotic serine/theronine kinase with multiple substrates and roles in the regulation of cellular processes such as cellular stress, cell proliferation and apoptosis.
Schmid, Ralf, Solyakov, Lev, Doerig, Christian, Graciotti, Michele, Burley, Glenn, Tobin, Andrew B, Cullis, Paul, Alam, Mahmood, Bottrill, Andrew R   +8 more
core  

AKAPs (A kinase anchoring protein) [PDF]

, 2008
openaire   +1 more source

The Role of A-Kinase Anchoring Proteins for Inhibitory cAMP Signalling in Platelets. [PDF]

Cells
Barkey S, Smolenski A.
europepmc   +1 more source