Results 131 to 140 of about 3,121 (209)

AMY-1 Interacts with S-AKAP84 and AKAP95 in the Cytoplasm and the Nucleus, Respectively, and Inhibits cAMP-dependent Protein Kinase Activity by Preventing Binding of Its Catalytic Subunit to A-kinase-anchoring Protein (AKAP) Complex [PDF]

, 2002
Makoto Furusawa, Takahiro Taira, Sanae M.M. Iguchi‐Ariga, Hiroyoshi Ariga   +3 more
openalex   +1 more source

Domain architecture of a Caenorhabditis elegans AKAP suggests a novel AKAP function

, 2000
A-kinase anchoring proteins (AKAPs) are adapter proteins that are involved in directing cAMP-dependent protein kinase and some other signaling enzymes to certain intracellular locations.
Jambeck, Per, Susan S. Taylor, Subramaniam, Shankar, Shankar Subramaniam, Taylor, Susan S., Herrgård, Sanna, Sanna Herrgård, Per Jambeck   +7 more
core   +1 more source

Neuronal microtubule-associated protein 2D is a dual a-kinase anchoring protein expressed in rat ovarian granulosa cells

, 2004
A-kinase anchoring proteins (AKAPs) function to target protein kinase A (PKA) to specific locations within the cell. AKAPs are functionally identified by their ability to bind the type II regulatory subunits (RII) of PKA in an in vitro overlay assay.
Scott, John D., Alam, Hena, Carr, Daniel W., Reierstad, Scott, Carr, Daniel W, Salvador, Lisa M, Ávila, Jesús, Scott, John D, Flynn, Maxfield P, Hunzicker-Dunn, Mary, Salvador, Lisa M., Park, Youngkyu, Maizels, Evelyn T, Flynn, Maxfield P., Maizels, Evelyn T.   +14 more
core   +1 more source

GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function

Nature Communications
Glucagon-like peptide-1 receptor (GLP-1R) agonists (GLP-1RAs) ameliorate mitochondrial health by increasing mitochondrial turnover in metabolically relevant tissues.
Gregory Austin, Affiong I. Oqua, Liliane El Eid, Mingli Zhu, Yusman Manchanda, Priyanka Peres, Helena Coyle, Yelyzaveta Poliakova, Zhanna Balkhiyarova, Karim Bouzakri, Alex Montoya, Dominic J. Withers, Michele Solimena, Ben Jones, Steven J. Millership, Steffen Burgold, David C. A. Gaboriau, Endre Majorovits, Evelyn Garlick, Maria Augusta do R. B. F. Lima, Inga Prokopenko, Jonathon Nixon-Abell, Andreas Müller, Alejandra Tomas   +23 more
doaj   +1 more source

Neurochondrin is an atypical RIIα-specific A-kinase anchoring protein

, 2015
Protein kinase activity is regulated not only by direct strategies affecting activity but also by spatial and temporal regulatory mechanisms. Kinase signaling pathways are coordinated by scaffolding proteins that orchestrate the assembly of multi-protein
Wagener, E.M., Hanold, L.E., von der Heide, E.K., Skroblin, P., Herberg, F.W., Bertinetti, D., Hermann, J.S., Kennedy, E.J., Zenn, H.M., Klussmann, E.   +9 more
core   +1 more source

Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes.

The Journal of biological chemistry, 1996
Compartmentalization of the type II cyclic AMP-dependent kinase (PKA) is achieved through association of the regulatory subunit (RII) with A-kinase anchoring proteins (AKAPs). Using an interaction cloning strategy with RIIalpha as a probe, we have isolated cDNAs encoding a novel 1129-amino acid protein that contains both a PKA binding region and a ...
L B, Lester, V M, Coghlan, B, Nauert, J D, Scott   +3 more
openaire   +1 more source

A-kinase anchoring proteins as potential drug targets

, 2012
A-kinase anchoring proteins (AKAPs) crucially contribute to the spatial and temporal control of cellular signalling. They directly interact with a variety of protein binding partners and cellular constituents, thereby directing pools of signalling ...
Troeger, J., Tröger, Jessica, Marie C Moutty, Skroblin, P., Jessica Tröger, Philipp Skroblin, Moutty, M.C., Skroblin, Philipp, Enno Klussmann, Klussmann, Enno, Moutty, Marie C, Klussmann, E.   +11 more
core   +1 more source

Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs) [PDF]

, 2018
Una Kjällquist, Rikard Erlandsson, Nicholas P. Tobin, Amjad Alkodsi, Ikram Ullah, Gustav Stålhammar, Eva Karlsson, Thomas Hatschek, Johan Hartman, Sten Linnarsson, Jonas Bergh   +10 more
openalex   +1 more source

A-kinase Anchoring Protein Targeting of Protein Kinase A in the Heart

, 2004
There is increasing evidence that subcellular targeting of signaling molecules is an important means of regulating the protein kinase A (PKA) pathway. Subcellular organization of the signaling molecules in the PKA pathway insures that a signal initiated ...
Mary L Ruehr, Mary Russell, Meredith Bond   +2 more
core   +1 more source

Additional file 4: of Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs)

, 2018
Una Kjällquist, Rikard Erlandsson, Nicholas P. Tobin, Amjad Alkodsi, Ikram Ullah, Gustav Stålhammar, Eva Karlsson, Thomas Hatschek, Johan Hartman, Sten Linnarsson, Jonas Bergh   +10 more
openalex   +1 more source