Results 111 to 120 of about 115,266,211 (193)

AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula

Communications Biology
The scaffolding A-kinase anchoring protein 150 (AKAP150) is critically involved in kinase and phosphatase regulation of synaptic transmission/plasticity, and neuronal excitability.
Sarah C. Simmons, William J. Flerlage, Ludovic D. Langlois, Ryan D. Shepard, Christopher Bouslog, Emily H. Thomas, Kaitlyn M. Gouty, Jennifer L. Sanderson, Shawn Gouty, Brian M. Cox, Mark L. Dell’Acqua, Fereshteh S. Nugent   +11 more
doaj   +1 more source

Exploring AKAPs in visual signaling

Frontiers in Molecular Neuroscience
The complex nature of the retina demands well-organized signaling to uphold signal accuracy and avoid interference, a critical aspect in handling a variety of visual stimuli.
Julia Tomczak, Joanna Mackiewicz, Malwina Lisek, Aleksandra Kaluza, Tomasz Boczek   +4 more
doaj   +1 more source

Perinuclear compartment controls calcineurin/MEF2 signaling for axonal outgrowth of hippocampal neurons

Frontiers in Molecular Neuroscience
Central to the process of axon elongation is the concept of compartmentalized signaling, which involves the A-kinase anchoring protein (AKAP)-dependent organization of signaling pathways within distinct subcellular domains.
Joanna Mackiewicz, Malwina Lisek, Julia Tomczak, Agata Sakowicz, Feng Guo, Feng Guo, Tomasz Boczek   +6 more
doaj   +1 more source

The Molecular Basis for Specificity at the Level of the Protein Kinase a Catalytic Subunit

Frontiers in Endocrinology, 2018
Assembly of multi enzyme complexes at subcellular localizations by anchoring- and scaffolding proteins represents a pivotal mechanism for achieving spatiotemporal regulation of cellular signaling after hormone receptor targeting [for review, see (1)]. In
Kristoffer Søberg, Bjørn Steen Skålhegg   +1 more
doaj   +1 more source

Multiple Facets of cAMP Signalling and Physiological Impact: cAMP Compartmentalization in the Lung

Pharmaceuticals, 2012
Therapies involving elevation of the endogenous suppressor cyclic AMP (cAMP) are currently used in the treatment of several chronic inflammatory disorders, including chronic obstructive pulmonary disease (COPD).
Martina Schmidt, Harm Maarsingh, Anouk Oldenburger   +2 more
doaj   +1 more source

cAMP signaling in blood platelets - old friends and new players.

Frontiers in Pharmacology, 2015
Atherothrombosis, the pathology underlying numerous cardiovascular diseases, is a major cause of death globally. Hyperactive blood platelets play a key role in the atherothrombotic process through the release of inflammatory mediators and formation of ...
Zaher eRaslan, Khalid M Naseem
doaj   +1 more source

Xgravin-like (Xgl), a novel putative a-kinase anchoring protein (AKAP) expressed during embryonic development in Xenopus

Mechanisms of Development, 2001
A-kinase anchoring proteins (AKAPs) are a heterogeneous family of scaffolding proteins that regulate the compartmentalization of signaling components, in particular that of the broad specificity kinase PKA. Here we describe the identification of a new member of this gene family, termed Xenopus gravin-like (Xgl), which encodes a highly acidic protein of
Klingbeil, Pamela, Frazzetto, Giovanni, Bouwmeester, Tewis   +2 more
openaire   +2 more sources

Functional Analysis of the Protein Kinase A Anchoring Protein Ht31

, 2005
Titelblatt und Inhaltsverzeichnis Abkürzungsverzeichnis Einleitung Material und Methoden Ergebnisse Diskussion Zusammenfassung / Summary Literaturverzeichnis Danksagungen, LebenslaufAKAP-Ht31/AKAP-Lbc gehört zu der Familie der A kinase ...
Blum, Christopher Thorsten Friedrich
core   +1 more source

Direct AKAP-mediated protein-protein interactions as potential drug targets

, 2008
A-kinase-anchoring proteins (AKAPs) are a diverse family of about 50 scaffolding proteins. They are defined by the presence of a structurally conserved protein kinase A (PKA)-binding domain.
Hundsrucker, Christian, E. Klussmann, C. Hundsrucker, Hundsrucker, C., Klussmann, E.   +4 more
core   +1 more source

Protein Kinase A Regulates Platelet Phosphodiesterase 3A through an A-Kinase Anchoring Protein Dependent Manner

Cells
Platelet activation is critical for haemostasis, but if unregulated can lead to pathological thrombosis. Endogenous platelet inhibitory mechanisms are mediated by prostacyclin (PGI2)-stimulated cAMP signalling, which is regulated by phosphodiesterase 3A (
Jawad S. Khalil, Robert Law, Zaher Raslan, Lih T. Cheah, Matthew S. Hindle, Ahmed A. Aburima, Mark T. Kearney, Khalid M. Naseem   +7 more
doaj   +1 more source