Results 111 to 120 of about 3,121 (209)

AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula

Communications Biology
The scaffolding A-kinase anchoring protein 150 (AKAP150) is critically involved in kinase and phosphatase regulation of synaptic transmission/plasticity, and neuronal excitability.
Sarah C. Simmons, William J. Flerlage, Ludovic D. Langlois, Ryan D. Shepard, Christopher Bouslog, Emily H. Thomas, Kaitlyn M. Gouty, Jennifer L. Sanderson, Shawn Gouty, Brian M. Cox, Mark L. Dell’Acqua, Fereshteh S. Nugent   +11 more
doaj   +1 more source

Perinuclear compartment controls calcineurin/MEF2 signaling for axonal outgrowth of hippocampal neurons

Frontiers in Molecular Neuroscience
Central to the process of axon elongation is the concept of compartmentalized signaling, which involves the A-kinase anchoring protein (AKAP)-dependent organization of signaling pathways within distinct subcellular domains.
Joanna Mackiewicz, Malwina Lisek, Julia Tomczak, Agata Sakowicz, Feng Guo, Feng Guo, Tomasz Boczek   +6 more
doaj   +1 more source

The Molecular Basis for Specificity at the Level of the Protein Kinase a Catalytic Subunit

Frontiers in Endocrinology, 2018
Assembly of multi enzyme complexes at subcellular localizations by anchoring- and scaffolding proteins represents a pivotal mechanism for achieving spatiotemporal regulation of cellular signaling after hormone receptor targeting [for review, see (1)]. In
Kristoffer Søberg, Bjørn Steen Skålhegg   +1 more
doaj   +1 more source

Characterization of an A-Kinase Anchoring Protein in Human Ciliary Axonemes

, 2002
Although protein kinase A (PKA) activation is known to increase ciliary beat frequency in humans the molecular mechanisms involved are unknown. We demonstrate that PKA is associated with ciliary axonemes where it specifically phosphorylates a 23-kDa ...
Sharon L. Milgram, Sherell K. Byrd, Patricia L. Kultgen, Kultgen, Patricia L., Byrd, Sherell K., Milgram, Sharon L., Lawrence E. Ostrowski, Ostrowski, Lawrence E.   +7 more
core   +1 more source

Multiple Facets of cAMP Signalling and Physiological Impact: cAMP Compartmentalization in the Lung

Pharmaceuticals, 2012
Therapies involving elevation of the endogenous suppressor cyclic AMP (cAMP) are currently used in the treatment of several chronic inflammatory disorders, including chronic obstructive pulmonary disease (COPD).
Martina Schmidt, Harm Maarsingh, Anouk Oldenburger   +2 more
doaj   +1 more source

Specification of spatial relationships in directed graphs of cell signaling networks

, 2008
Graph theory provides a useful and powerful tool for the analysis of cellular signaling networks. Intracellular components such as cytoplasmic signaling proteins, transcription factors and genes are connected by links, representing various types of ...
Susana R. Neves, Ravi Iyengar, Azi Lipshtat   +2 more
core  

IQ Motif Containing GTPase Activating Proteins (IQGAPs), A-Kinase Anchoring Proteins (AKAPs) and Kinase Suppressor of Ras Proteins (KSRs) in Scaffolding Oncogenic Pathways and Their Therapeutic Potential [PDF]

, 2022
Talina Mohapatra, Manjusha Dixit
openalex   +1 more source

cAMP signaling in blood platelets - old friends and new players.

Frontiers in Pharmacology, 2015
Atherothrombosis, the pathology underlying numerous cardiovascular diseases, is a major cause of death globally. Hyperactive blood platelets play a key role in the atherothrombotic process through the release of inflammatory mediators and formation of ...
Zaher eRaslan, Khalid M Naseem
doaj   +1 more source

Kinase-anchoring proteins and the intracellular targeting of cyclic adenosine monophosphate (cAMP)-dependent protein kinase

, 2007
Kinase anchoring proteins (AKAPs) are a family of structurally diverse multidomain proteins classified solely by their ability to bind cAMP-dependent protein kinase/protein kinase A (PKA).
Alison Jane Davis (7656008)
core  

AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway.

, 2008
Elevated catecholamines in the heart evoke transcriptional activation of the Myocyte Enhancer Factor (MEF) pathway to induce a cellular response known as pathological myocardial hypertrophy.
Pedroja, B.S., Kunkel, M.T., Diviani, D., Zhang, F., Langeberg, L.K., Bristow, M.R., Newton, A.C., Carnegie, G.K., Smith, F.D., Soughayer, J., Scott, J.D.   +10 more
core   +1 more source