The focal adhesion protein talin is a mechanically-gated A-kinase anchoring protein (AKAP) [PDF]
, 2023 The cAMP-dependent protein kinase (Protein Kinase A; PKA) is a ubiquitous, promiscuous kinase whose activity is focused and specified through subcellular localization mediated by A-kinase anchoring proteins (AKAPs).
Goult, Benjamin T +7 more
core +5 more sources
Spatial distribution of protein kinase A activity during cell migration is mediated by A-kinase anchoring protein AKAP Lbc. [PDF]
J Biol Chem, 2009 Protein kinase A (PKA) has been suggested to be spatially regulated in migrating cells due to its ability to control signaling events that are critical for polarized actin cytoskeletal dynamics. Here, using the fluorescence resonance energy transfer-based A-kinase activity reporter (AKAR1), we find that PKA activity gradients form with the strongest ...
Paulucci-Holthauzen AA +5 more
europepmc +6 more sources
Biophysical and aerodynamic properties of a peptide targeting the A-kinase anchoring function of PI3Kγ for pulmonary cAMP modulation [PDF]
Scientific ReportsCyclic AMP (cAMP) signaling specificity relies on precise spatial regulation mediated by A-kinase anchoring proteins (AKAPs), which localize protein kinase A (PKA) within defined microdomains.
Angela Della Sala +12 more
doaj +2 more sources
Functional and Structural Mimicry of Cellular Protein Kinase A Anchoring Proteins by a Viral Oncoprotein. [PDF]
PLoS Pathogens, 2016 The oncoproteins of the small DNA tumor viruses interact with a plethora of cellular regulators to commandeer control of the infected cell. During infection, adenovirus E1A deregulates cAMP signalling and repurposes it for activation of viral gene ...
Cason R King +5 more
doaj +2 more sources
Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation
eLife, 2013 Anchoring proteins sequester kinases with their substrates to locally disseminate intracellular signals and avert indiscriminate transmission of these responses throughout the cell.
F Donelson Smith +6 more
doaj +3 more sources
Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP-Lbc signaling complex
EMBO Journal, 2004 A-kinase anchoring proteins (AKAPs) target the cAMP-regulated protein kinase (PKA) to its physiological substrates. We recently identified a novel anchoring protein, called AKAP-Lbc, which functions as a PKA-targeting protein as well as a guanine ...
Dario Diviani
exaly +2 more sources
Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins
Frontiers in Pharmacology, 2015 Cyclic AMP is a ubiquitous intracellular second messenger involved in the regulation of a wide variety of cellular processes, a majority of which act through the cAMP - protein kinase A (PKA) signalling pathway and involve PKA phosphorylation of specific
Ana Isabel C. Calejo, Kjetil eTaskén
doaj +2 more sources
Journal of Pharmacological Sciences, 2008 In our previous study, anti-apoptotic effects of GABAC-receptor stimulation was suppressed by inhibitors of cAMP-dependent protein kinase (PKA), implying GABACreceptor–mediated PKA activation. The present study showed that GABAC-receptor stimulation with
Li Yang +4 more
doaj +2 more sources
AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex
American Journal of Physiology-Heart and Circulatory Physiology, 2001 In cardiac myocytes, the slow component of the delayed rectifier K+current ( IKs) is regulated by cAMP. Elevated cAMP increases IKsamplitude, slows its deactivation kinetics, and shifts its activation curve.
Raha Mohammad-Panah +4 more
core +3 more sources
Role of a-kinase anchoring proteins (AKAPs) in reproduction [PDF]
Frontiers in Bioscience, 2010 Rapid spatio-temporal organized intracellular signaling is a pivotal mechanism for regulation of functions in many cells, in particular in the female and male gametes, in which functional regulation through rapid increases in protein content is not possible since the mechanisms of transcription/translation are somehow frozen due to meiosis block or DNA
Michaela Luconi
openalex +5 more sources