A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in α1-adrenergic receptor-induced p38 activation. [PDF]
J Biol Chem, 2011 The mitogen-activated protein kinases (MAPKs) pathways are highly organized signaling systems that transduce extracellular signals into a variety of intracellular responses. In this context, it is currently poorly understood how kinases constituting these signaling cascades are assembled and activated in response to receptor stimulation to generate ...
Cariolato L, Cavin S, Diviani D.
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The A-kinase-anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser(16). [PDF]
Biochem J, 2012 Hsp20 (heat-shock protein of 20 kDa; HspB6) is a cardioprotective agent which combats a number of pathophysiological processes in the heart, including hypertrophy, apoptosis and ischaemia/reperfusion injury. The cardioprotective actions of Hsp20 require its phosphorylation by PKA (cAMP-dependent protein kinase) on Ser16.
Edwards HV, Scott JD, Baillie GS.
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A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane. [PDF]
J Biol Chem, 2012 Protein kinase A-anchoring proteins (AKAPs) provide spatio-temporal specificity for the omnipotent cAMP-dependent protein kinase (PKA) via high affinity interactions with PKA regulatory subunits (PKA-RI, RII). Many PKA-RII-AKAP complexes are heavily tethered to cellular substructures, whereas PKA-RI-AKAP complexes have remained largely undiscovered ...
Burgers PP +8 more
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The focal adhesion protein talin is a mechanically-gated A-kinase anchoring protein (AKAP) [PDF]
, 2023 Abstract The cAMP-dependent protein kinase (Protein Kinase A; PKA) is a ubiquitous, promiscuous kinase whose activity is focused and specified through subcellular localization mediated by A-kinase anchoring proteins (AKAPs). PKA has complex roles as both an effector and a regulator of integrin-mediated cell adhesion to the extracellular
Mingu Kang +5 more
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Functional and Structural Mimicry of Cellular Protein Kinase A Anchoring Proteins by a Viral Oncoprotein. [PDF]
PLoS Pathogens, 2016 The oncoproteins of the small DNA tumor viruses interact with a plethora of cellular regulators to commandeer control of the infected cell. During infection, adenovirus E1A deregulates cAMP signalling and repurposes it for activation of viral gene ...
Cason R King +5 more
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Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation [PDF]
eLife, 2013 Anchoring proteins sequester kinases with their substrates to locally disseminate intracellular signals and avert indiscriminate transmission of these responses throughout the cell.
F Donelson Smith +6 more
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AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex
American Journal of Physiology-Heart and Circulatory Physiology, 2001 In cardiac myocytes, the slow component of the delayed rectifier K+current ( IKs) is regulated by cAMP. Elevated cAMP increases IKsamplitude, slows its deactivation kinetics, and shifts its activation curve. At the molecular level, IKschannels are composed of KvLQT1/IsK complexes.
F, Potet +4 more
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A-kinase anchoring in dendritic cells is required for antigen presentation. [PDF]
PLoS ONE, 2009 BACKGROUND: Dendritic cells (DC) are the most potent antigen presenting cells (APC) of the immune system. Prostaglandin E(2), cyclic AMP, and protein kinase A (PKA) have all been shown to regulate DC maturation and activity.
Robynn V Schillace +6 more
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Molecular Pain, 2023 Changes in sensory afferent activity contribute to the transition from acute to chronic pain. However, it is unlikely that a single sensory receptor is entirely responsible for persistent pain.
Yan Zhang, Nathaniel A Jeske
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A-Kinase Anchoring Protein 2 Promotes Protection against Myocardial Infarction
Cells, 2021 Myocardial infarction (MI) is a leading cause of maladaptive cardiac remodeling and heart failure. In the damaged heart, loss of function is mainly due to cardiomyocyte death and remodeling of the cardiac tissue.
Darko Maric +5 more
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