Results 71 to 80 of about 115,303,296 (139)

Functional studies of serine/threonine protein kinase signalling in Mycobacterium tuberculosis. [PDF]

, 2006
Fork-head associated (FHA) domains function in the assembly of signalling complexes through specific interactions with phospho-threonine motifs. FHA domains are found in eukaryotes, and intriguingly in a subset of bacterial species including Mycobacteria
Patel, D.P.
core  

Deep evolutionary conservation of an intramolecular protein kinase activation mechanism [PDF]

, 2012
DYRK-family kinases employ an intramolecular mechanism to autophosphorylate a critical tyrosine residue in the activation loop. Once phosphorylated, DYRKs lose tyrosine kinase activity and function as serine/threonine kinases.
Cleghon Vaughn, Aman Singh (191216), Cleghon, V., Nathan Luebbering (191210), Sibbet Gary, Jingfen Han, Luebbering Nathan, Nathan Luebbering, Michael A J Ferguson, Singh, A., Aman Singh, Ferguson, M.A.J., Ferguson Michael A. J., Hong, W., Diego Miranda-Saavedra (36622), Michael A. J. Ferguson (166662), Jingfen Han, Han, J., Gary Sibbet (191221), Vaughn Cleghon (191224), Miranda-Saavedra Diego, Sibbet, G., Ferguson, M.A.J.; id_orcid, Han Jingfen, Miranda-Saavedra, D., Gary Sibbet, Luebbering, N., Diego Miranda-Saavedra, Michael A. J. Ferguson, Vaughn Cleghon, Singh Aman, Jingfen Han (191204)   +31 more
core   +1 more source

An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma

eLife, 2019
Fibrolamellar carcinoma (FLC) is a rare liver cancer. FLCs uniquely produce DNAJ-PKAc, a chimeric enzyme consisting of a chaperonin-binding domain fused to the Cα subunit of protein kinase A.
Rigney E Turnham, F Donelson Smith, Heidi L Kenerson, Mitchell H Omar, Martin Golkowski, Irvin Garcia, Renay Bauer, Ho-Tak Lau, Kevin M Sullivan, Lorene K Langeberg, Shao-En Ong, Kimberly J Riehle, Raymond S Yeung, John D Scott   +13 more
doaj   +1 more source

Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis [PDF]

, 2003
We have investigated the function of mitotic kinesin-like protein (MKlp) 2, a kinesin localized to the central spindle, and demonstrate that its depletion results in a failure of cleavage furrow ingression and cytokinesis, and disrupts localization of ...
Mayer, Thomas U., Erich A. Nigg, Francis A. Barr, Neef, Rüdiger, Josephine Sutcliffe, Kopajtich, R., Rüdiger Neef, Nigg, E. A., Robert Kopajtich, Mayer, T. U., Thomas U. Mayer, Christian Preisinger, Preisinger, C., Neef, R., Sutcliffe, J., Barr, F. A., Nigg, Erich A., Sutcliffe, Josephine, Kopajtich, Robert, Preisinger, Christian, Barr, Francis A.   +20 more
core   +1 more source

Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation

eLife, 2013
Anchoring proteins sequester kinases with their substrates to locally disseminate intracellular signals and avert indiscriminate transmission of these responses throughout the cell.
F Donelson Smith, Steve L Reichow, Jessica L Esseltine, Dan Shi, Lorene K Langeberg, John D Scott, Tamir Gonen   +6 more
doaj   +1 more source

Regulation of CaMKII signaling in cardiovascular disease

Frontiers in Pharmacology, 2015
Heart failure (HF) is a major cause of death in the developed countries. (Murray and Lopez, 1996;Koitabashi and Kass, 2012). Adverse cardiac remodeling that precedes heart muscle dysfunction is characterized by a myriad of molecular changes affecting the
Mariya Yordanova Mollova, Mariya Yordanova Mollova, Hugo Albert Katus, Hugo Albert Katus, Johannes eBacks, Johannes eBacks   +5 more
doaj   +1 more source

Combinatorial strategy using protein kinase inhibitors and a cytotoxic compound for highly resistant glioblastoma cells : "in vitro studies" [PDF]

, 2007
Glioblastoma multiforme (GBM) is the most frequent and the most aggesssive malignant neoplasm of the human central nervous system (CNS), with a median survival of less than one year. These neoplasms are radio- and chemo-resistant, and are highly invasive,
Failly, Mike
core   +1 more source

Solid Phase Peptide Synthesis: Analysis and Identification of Protein Kinase Substrates [PDF]

, 2005
This research study examines the synthesis of tyrosine containing peptides based on the protein paxillin. Paxillin is a proposed substrate of the Focal Adhesion Kinase (FAK) protein tyrosine kinase.
Kroodsma, Derrick
core  

Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway [PDF]

, 2012
Background Protein kinase CK2 is a pleiotropic serine/threonine protein kinase with hundreds of reported substrates, and plays an important role in a number of cellular processes.
Hamelin, R., Hamelin Romain, Marc Moniatte, Amit Sharma, Chêne Arnaud, Doerig Christian, Lopez-Rubio, Jose-Juan, Dayer Guillem, Sharma, Amit, Dorin-Semblat Dominique, Dominique Dorin-Semblat, Doerig, C., Holland, Zoe M., Claes, Aurelie, Scherf, Artur, Guillem Dayer, Moniatte Marc, Sharma, A., Dayer, Guillem, Moniatte, Marc, Eeshita G Dastidar, Moniatte, M., Dorin-Semblat, Dominique, Chene, A., Dastidar, Eeshita, Claes Aurélie, Scherf, A., Aurelie Claes, Artur Scherf, Jose-Juan Lopez-Rubio, Lopez-Rubio Jose-Juan, Romain Hamelin, Claes, A., Sharma Amit, Dastidar Eeshita G, Zoe M Holland, Lopez-Rubio, J-J., Hamelin, Romain, Chene, Arnaud, Dayer, G., Scherf Artur, Dastidar, E.G., Doerig, Christian, Arnaud Chene, Dastidar, Eeshita G., Holland, Z.M., Dorin-Semblat, D., Holland Zoe M, Holland, Zoe, Christian Doerig   +49 more
core   +1 more source

Molecular basis of AKAP79 regulation by calmodulin

Nature Communications, 2017
The A-kinase anchoring protein AKAP79 is regulated by calmodulin (CaM). Here, the authors use crosslinking coupled to mass spectrometry to identify the CaM-binding site in AKAP79 and present the structure of CaM bound to an AKAP79 peptide.
Neha Patel, Florian Stengel, Ruedi Aebersold, Matthew G. Gold   +3 more
doaj   +1 more source